Structure and function of N-acetylglucosamine kinase. Identification of two active site cysteines

European Journal of Biochemistry

Volumn 269, Issue 17, 2002, Pages 4212-4218

  Berger, Markus ^a   Chen, Hao ^a   Reutter, Werner ^a   Hinderlich, Stephan ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Aminosugar metabolism; ATP binding domain; Cysteine residue; N acetylglucosamine; N acetylglucosamine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYSTEINE DERIVATIVE; GLUCOKINASE; MUTANT PROTEIN; N ACETYLGLUCOSAMINE KINASE; PHOSPHATE; PHOSPHOTRANSFERASE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER ANALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; MOLECULAR MODEL; MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; REDUCTION; SITE DIRECTED MUTAGENESIS;

ACETYLGLUCOSAMINE; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE; DNA PRIMERS; ESCHERICHIA COLI; GLUCOKINASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; MURINAE;

EID: 0036375994     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03117.x     Document Type: Article

References (31)

1. The 'yellow brick road' to branched complex N-glycans
2. O-GlcNAcylation of key nuclear and cytoskeletal proteins: Reciprocity with O-phosphorylation and putative roles in protein multimerization
3. The biology of sialic acids. Insights into their structure, metabolism and function in particular during viral infection
4. Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity
5. Glucosamine metabolism. IV. Glucosamine 6-phosphate deaminase
6. Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells
7. Functional interaction between the ser/thr kinase PKL12 and GlcNAc kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling
8. Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans
9. Molecular cloning and characterization of murine and human N-acetylglucosamine kinase
10. Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation
11. A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
12. A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase
13. An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins
14. Purification and characterization of N-acetylglucosamine kinase from rat liver - Comparison with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Basic local alignment search tool
17. Multiple sequence alignment with hierarchical clustering
18. Prediction of protein secondary structure at better than 70% accuracy
19. Protein secondary structure prediction based on position-specific scoring matrices
20. Cascaded multiple classifiers for secondary structure prediction
21. The isolation and preliminary characterization of N-acetyl-D-glucosamine kinase from rat kidney and liver
22. Pancreatic islet glucose metabolism and regulation of insulin secretion
23. Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B
24. The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution
25. Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation
26. Evidence for multiple pairs of vicinal thiols in some proteins
27. Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase
28. Structural model of human glucokinase in complex with glucose and ATP: Implications for the mutants that cause hypo- and hyperglycemia
29. Induced fit in yeast hexokinase
30. Studies on hog spleen N-acetylglucosamine kinase. II. Allosteric regulation of the activity of N-acetylglucosamine kinase