Lipopolysaccharide binds to and activates A1 adenosine receptors on human pulmonary artery endothelial cells

Journal of Endotoxin Research

Volumn 8, Issue 4, 2002, Pages 263-271

  Wilson, Constance Neely ^a   Batra, Vinod K ^a  

^a Endacea Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 ANILINOADENOSINE; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 3 (4 AMINO 3 IODOBENZYL) 8 CYCLOPENTYL 1 PROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR AGONIST; BACTERIUM LIPOPOLYSACCHARIDE; ENTEROTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GALACTOSYLCERAMIDE; GLYCOLIPID; INTERLEUKIN 6; IODINE 125; LIPID A DERIVATIVE; MONOSIALOGANGLIOSIDE; RADIOLIGAND; THROMBOXANE A2;

ARTERY ENDOTHELIUM; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENDOTHELIUM CELL; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; IC 50; KLEBSIELLA PNEUMONIAE; LIGAND BINDING; LUNG ARTERY; LUNG INJURY; NONHUMAN; PATHOPHYSIOLOGY; PSEUDOMONAS AERUGINOSA; RECEPTOR UPREGULATION; SALMONELLA TYPHIMURIUM; SEPTICEMIA;

ADENOSINE; BINDING, COMPETITIVE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GLYCOLIPIDS; GRAM-NEGATIVE BACTERIA; HUMANS; INTERLEUKIN-6; LIPID A; LIPOPOLYSACCHARIDES; PHENETHYLAMINES; PULMONARY ARTERY; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; THROMBOXANE A2; XANTHINES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM;

EID: 0036374565     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805102125000470     Document Type: Article

References (49)

1. 1-adenosine receptor antagonists block endotoxin-induced lung injury
2. The association of circulating endotoxin with the development of the adult respiratory distress syndrome
3. Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease
4. Endotoxemia in human septic shock
5. Response of cultured human pulmonary artery endothelial cells to endotoxin
6. Lipopolysaccharide receptors and signal transduction pathways in mononuclear phagocytes
7. Molecular mechanisms of endotoxin activity
8. Endotoxin alters arachidonate metabolism in pulmonary endothelial cells
9. Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin
10. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages
11. Endotoxin and lung injury
12. Multiple receptors for endotoxin
13. Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene
14. Antiproteinases protect cultured lung endothelial cells from endotoxin injury
15. 2 synthase-2 by lipopolysaccharide in human polymorphonuclear leukocytes
16. Recognition of Gram-negative bacteria and endotoxin by the innate immune system
17. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
18. Lipopolysaccharide (LPS) binding to 73-kDa and 38-kDa surface proteins on lymphoreticular cells: Preferential inhibition of LPS binding to the former by Rhodopseudomonas sphaeroides lipid A
19. Biotinylated lipopolysaccharide binds to endotoxin receptor in endothelial and monocytic cells
20. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
21. Tlr4: Central component of the sole mammalian LPS sensor
22. Bacterial lipopolysaccharide activates NF-κB through Toll-like receptor (Tlr-4) in cultured human dermal endothelial cells
23. Moesin functions as a lipopolysaccharide receptor on human monocytes
24. Regulation of inducible nitric oxide synthase expression by macrophage purinoceptors and calcium
25. Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages
26. Toll, a new piece in the puzzle of innate immunity
27. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mmutations in the Tlr4 gene
28. The role of receptor structure in determining adenosine receptor activity
29. 2 receptors: Structure-function relationships
30. 1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release
31. 1 receptor
32. Endotoxin signal transduction in macrophages
33. Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide
34. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide
35. 2, in the promonocytic cell line U937
36. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-α
37. Endotoxin-induced arachidonic acid metabolism requires do novo protein synthesis and protein kinase C activation
38. Direct effects of E. coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants
39. Bacterial lipopolysaccharide induces actin reorganization, intercellular gap formation, and endothelial barrier dysfunction in pulmonary vascular endothelial cells: Concurrent F-actin depolymerization and new actin synthesis
40. Thromboxane contributes to pulmonary hypertension in ischemia-reperfusion lung injury
41. Endotoxin interactions with lipopolysaccharide-responsive cells
42. Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge
43. Phosphatidylcholine-specific phospholipase C and D in stimulation of RAW264.7 mouse macrophage-like cells by lipopolysaccharide
44. Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance
45. Adenosine and ATP produce vasoconstriction in the feline pulmonary vascular bed by different mechanisms
46. Mechanisms of signal transduction for adenosine and ATP in the pulmonary vascular bed
47. In vitro effects of endotoxin on bovine and sheep lung microvascular and pulmonary artery endothelial cells
48. Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells
49. Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages