Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: Differential regulation in the various types of cells in the lung

American Journal of Pathology

Volumn 156, Issue 4, 2000, Pages 1275-1287

  Ermert, Leander ^a   Ermert, Monika ^a   Merkle, Martin ^a   Goppelt Struebe, Margarete ^b   Duncker, Hans Rainer ^a   Grimminger, Friedrich ^a   Seeger, Werner ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYCLOOXYGENASE 2;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME INDUCTION; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY DISTRESS SYNDROME;

EID: 0033838882     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64998-X     Document Type: Article

References (61)

1. Endotoxin and lung injury
2. Recognition of bacterial endotoxin in biologic systems
3. Recognition of bacterial endotoxins by receptor-dependent mechanisms
4. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
5. Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein
6. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
7. Soluble CD14 participates in the response of cells to lipopolysaccharide
8. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
9. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
10. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
11. Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide
12. CD14-independent responses to LPS require a serum factor that is absent from neonates
13. Multiple receptors for endotoxin
14. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide
15. Septin: A factor in plasma that opsonizes lipopolysaccharide-bearing particles for recognition by CD14 on phagocytes
16. Identification of the 80-kDa LPS-binding protein (LMP80) as decay-accelerating factor (DAF, CD55)
17. Endotoxin-induced lung injury in rats: Role of eicosanoids
18. Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs
19. Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin
20. Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs
21. Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression
22. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes
23. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
24. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: Regulation by dexamethasone
25. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
26. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
27. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
28. Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet
29. Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo
30. Multiple female reproductive failures in cyclooxygenase 2-deficient mice
31. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
32. Cox-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
33. Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs
34. Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs
35. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages
36. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2
37. Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosin kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide
38. Endotoxin 'priming' potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: An example of synergism between endo- and exotoxin
39. Synergism between endotoxin priming and exotoxin challenge in provoking severe vascular leakage in rabbit lungs
40. Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat
41. Synergism of alveolar endotoxin 'priming' and intravascular exotoxin challenge in lung injury
42. Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits
43. Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H-synthase-2 isozymes
44. Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells
45. Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth muscle cells
46. Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts
47. Marginated pool of neutrophils in rabbit lungs
48. Computer-assisted morphometry of the intracapillary leukocyte pool in the rabbit lung
49. Morphometric analysis of pulmonary intracapillary leukocyte pools in ex vivo-perfused rabbit lungs
50. The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes
51. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage
52. Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: Dependence on lipopolysaccharide binding protein and CD14
53. Compartmentalized lung cytokine release in response to intravascular and alveolar endotoxin challenge
54. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics
55. Inducible cyclooxygenase may have anti-inflammatory properties
56. Cox-2 inhibitors - Is there cause for concern?
57. Cyclooxygenase-2 dependent arachidonic acid metabolites are critical modulators of the intestinal immune response to dietary antigen
58. Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide
59. Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro
60. 2-synthase in normal and LPS-primed lungs
61. Vascular remodeling