Monocarboxylate transporters and lactate metabolism in equine athletes: A review

Acta Veterinaria Scandinavica

Volumn 43, Issue 2, 2002, Pages 63-74

  Poso A R ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Exercise; Horse; MCT; Red blood cell; Skeletal muscle

Indexed keywords

EQUIDAE;

LACTIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORTER;

ANIMAL; ANIMAL EXPERIMENT; ENERGY METABOLISM; HORSE; METABOLISM; PHYSIOLOGY; REVIEW; SKELETAL MUSCLE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; ENERGY METABOLISM; HORSES; LACTATES; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL;

EID: 0036359079     PISSN: 0044605X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1751-0147-43-63     Document Type: Review

References (73)

1. Baker SK, McCullagh KJA, Bonen A: Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle. J. appl. Physiol. 1998, 84, 987-994.
2. Bangsbo J, Graham T, Johansen L, Saltin B: Muscle lactate metabolism in recovery from intense echaustive exercise: Impact of light exercise. J. appl. Physiol. 1994, 77, 1980-1985.
3. Bonen A, McCullagh KJA, Putman CT, Hultman E, Jones NL, Heigenhauser GJF: Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. Am. J. Physiol. 1998, 274, E102-E107.
4. Booth FW, Thomason DB: Molecular and cellular adaptation of muscle in response to exercise: Perspectives of various models. Physiol. Rev. 1991, 71, 541-585.
5. Brooks GA: Current concepts in lactate exchange. Med. Sci. Sports Exerc. 1991, 23, 895-906.
6. Brooks GA, Brown MA, Butz CE, Sicurello JP, Dubouchaud H: Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1. J. appl. Physiol. 1999a, 87, 1713-1718.
7. Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE: Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc. natl Acad. Sci. USA 1999b, 96, 1129-1134.
8. Cutmore CMM, Snow DH, Newsholme EA: Activities of key enzymes of aerobic and anaerobic metabolism in middle gluteal muscle from trained, and untrained horses. Equine vet. J. 1993. 17, 354-356.
9. Derman KD, Noakes TD: Comparative aspects of exercise physiology. In: Hodgson DR, Rose RJ (eds): The Athletic Horse. Philadelphia. PA. Saunders: 1994, pp 13-25.
10. Donovan CM, Brooks GA: Endurance training affects lactate clearance not lactate production. Am. J. Physiol. 1983, 244 E83-E92.
11. Dubouchaud H, Butterfied GE, Wolfel EE, Bergman BC, Brooks GA: Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am. J. Physiol. 2000. 278, E571-E579.
12. Dunnett M, Harris RC: Carnosine and taurine contents of type I, IIA and IIB fibers in the middle gluteal muscle. Equine vet. J. 1995, Suppl. 18, 214-217.
13. Eaton MD: Energetics and performance. In: Hodgins DR, Rose RJ (eds): The Athletic Horse. Philadelphia, PA. Saunders: 1994, pp. 49-61.
14. Essén-Gustavsson B, Karlström K, Lindholm A: Fibre types, enzyme activities and substrate utilisation in skeletal muscles of horses competing in endurance races. Equine vet. J. 1984, 16, 197-202.
15. Evans DL, Rose RJ: Determination and repeatability of maximum oxygen uptake and other cardiorespiratory measurements in the exercising horse. Equine vet. J. 1988, 20, 94-98.
16. Fishbein WN: Lactate transporter defect: a new disease of muscle. Science 1986, 234, 1254-1256.
17. Fitts RH: Cellular mechanisms of muscle fatigue. Physiol. Rev. 1994, 4, 49-94.
18. Fox G, Henckel P, Juel C, Falk-Rønne J, Saltin B: Skeletal muscle buffer capacity changes in Standardbred horses: effects of growth and training. In: Gillespie JR, Robinson NE (eds): Equine Exercise Physiology 2. Davis, CA, ICEEP Publications: 1987, pp 341-347.
19. Francaux M, Jacqmin J, Dewelle JM, Sturbois X: A study of lactate metabolism without tracer during passive and active postexercise recovery in humans. Eur. J. appl. Physiol. 1995, 72, 58-66.
20. Grichko VP, Gettelman GJ, Widrick JJ, Fitts RH: Substrate and enzyme profile of fast and slow skeletal muscle fibers in rhesus monkeys. J. appl. Physiol. 1999, 86, 335-340.
21. Halestmp AP, Price NT: The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 1999, 343, 281-299.
22. Halperin ML, Rolleston FS: Clinical Detective Stories. London, Portland Press: 1993, pp. 258.
23. Harris RC, Marlin DJ, Dunnett M, Snow DH, Hultman E: Muscle buffering capacity and dipeptide content in teh Thoroughbred horse, Greyhound dog and man. Comp. Biochem. Physiol. 1990, 97, 249-251.
24. Harris RC, Snow DH, Katz A, Sahlin K: Effect of freeze-drying on measurements of pH in biopsy samples of the middle gluteal muscle of the horse: comparison of muscle pH to the pyruvate and lactate content. Equine vet. J. 1989, 21, 45-47.
25. Henriksson J, Chi MMY, Hintz CS, Young DA, Kaiser KK, Salmons S, Lowry OH: Chronic stimulation of mammalian muscle: changes in enzyme of six metabolic pathways. Am. J. Physiol. 1986, 251, C614-C632.
26. Hyyppä S, Pösö AR: Fluid, electrolyte, and acid-base responses to exercise in racehorses. Vet. Clin. N. A.: Equine Pract. 1998, 14, 121-136.
27. Jones WE: Equine Sports Medicine. Philadelphia, PA, Lea & Febiger: 1989, pp 121-136.
28. Juel C: Lactate/proton co-transport in skeletal muscle: regulation and importance for pH homeostasis. Acta physiol. scand. 1996, 156, 369-374.
29. Juel C: Lactate-proton cotransport in skeletal muscle. Physiol. Rev. 1997, 77, 321-358.
30. Juel C, Bangsbo J, Graham T, Saltin B: Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise. Acta physiol. scand. 1990, 140, 147-159.
31. Karlström K, Essén-Gustavsson B, Lindholm A: Fibre type distribution, capillarization and enzymatic profile of locomotor and nonlocomotor muscles of horses and steers. Acta anat. 1994, 151, 97-106.
32. Kingston JK, Bayly WM: Effect of exercise on acid-base status of horses. Vet. Clin. N. A.: Equine Pract. 1998, 14, 61-73.
33. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D: Functional significance of cell volume regulatory mechanisms. Physiol. Rev. 1998, 78, 247-306.
34. Lovell DK, Reid TA, Rose RJ: Effects of maximal exercise on equine muscle: changes in metabolites, pH and temperature. In: Gillespie JR. Robinson NE (eds): Equine Exercise Physiology 2. Davis, CA, ICEEP Publications: 1987, pp 312-320.
35. Mannion AF, Jakeman PM, Willan PLT: Skeletal muscle buffer value, fibre type distribution and high intensity exercise performance in man. Exp. Physiol. 1995, 80, 89-101.
36. Marlin DJ, Harris RC: Carnosine content of the middle gluteal muscle in Thoroughbred horses with relation to age, sex and training. Comp. Biochem. Physiol. 1989, 93, 629-632.
37. Marlin DJ, Harris RC, Harman JC, Snow DH: Influence of post-exercise activity on rates of muscle and blood lactate disappearance in the Thoroughbred horse. In: Gillespie JR, Robinson NE (eds): Equine Exercise Physiology 2. Davis CA. ICEEP Publications: 1987, pp 321-331.
38. McCullagh KJA, Poole RC, Halestrap AP, O'Brien M, Bonen A: Role of lactate transporter (MCT) in skeletal muscles. Am. J. Physiol. 1996, 271, E143-E150.
39. McCullagh KJA, Poole RC, Halestrap AP; Tipton KF, O'Brien M, Bonen, A: Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle. Am. J. Physiol., 1997, 273, E239-E246.
40. McCutcheon LJ, Kelso TB, Bertocci LA, Hodgson DR, Bayly WM, Gollnick PD: Buffering and aerobic capacity in equine muscle: variation and effect of training. In: Gillespie JR., Robinson NE (eds): Equine Exercise Physiology 2. Davis, CA, ICEEP Publications: 1987, pp 348-358.
41. McMiken D: Muscle fiber types and horse performance. Equine Pract. 1986, 8, 6-15.
42. Newsholme EA, Leech AR: Biochemistry for the Medical Sciences. Chichester, John Wiley & Sons: 1986, pp 357-381.
43. Pagliassotti MJ, Donovan CM: Role of cell type in net lactate removal by skeletal muscle. Am. J. Physiol. 1990, 258, E635-E642.
44. Persson SGB: Evaluation of exercise tolerance and fitness in the performance horse. In: Snow DH, Persson SGB, Rose RJ (eds.) Equine Exercise Physiology. Cambridge. Granta Editions: 1983, pp 441-457.
45. LA4. Equine vet. J. 1995, Suppl. 18, 104-107.
46. Phillips SM, Green HJ, Tarnopolsky MA, Grant SM: Increased clearance of lactate after short-term training in men. J. appl. Physiol. 1995, 79, 1862-1869.
47. Pilegaard H, Bangsbo J, Richter EA, Juel C: Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. J. appl. Physiol. 1994, 77, 1858-1862.
48. + transport capacity in human skeletal muscle. Am. J. Physiol. 1999, 276, E255-E261.
49. Poole RC, Halestrap AP: Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 1993, 264, C761-C782.
50. +/Lactate cotransporter (MCT1). Biochem. J. 1996, 320, 817-824.
51. Pösö AR, Lampinen KJ, Räsänen LA: Distribution of lactate between red blood cells and plasma after exercise. Equine vet. J. 1995, Suppl. 18, 231-234.
52. Pösö AR, Nieminen M, Raulio J, Räsänen LA, Soveri T: Skeletal muscle characteristics of racing rein deer (Rangifer tarandus). Comp. Biochem. Physiol. 1996, 114A, 277-281.
53. Räsänen LA, Lampinen KJ, Pösö AR: Responses of blood and plasma lactate and plasma purine concentrations to maximal exercise and their relation to performance in Standardbred trotters. Am. J. vet. Res. 1995, 56, 1651-1656.
54. Ronéus M, Lindholm A, Åsheim Å: Muscle characteristics of Thoroughbreds of different ages and sexes. Equine vet. J. 1991, 23, 207-210.
55. Ronéus M, Persson SGB, Essén-Gustavsson B, Árnason T: Skeletal muscle characteristics in red blood cell normovolaemic and hypervolaemic Standardbred racehorse. Equine vet. J. 1994, 26, 319-322.
56. 2 uptake, O2 debt and deficit, and muscle metabolites in Thoroughbred horses. J. appl. Physiol. 1988, 64, 781-788.
57. Ryan C, Radziuk J: Distinguishable substrate pools for muscle glyconeogenesis in lactate-supplemented recovery from exercise. Am. J. Physiol. 1995, 269, E538-E550.
58. Sahlin K, Henriksson J: Buffer capacity and lactate accumulation in skeletal muscle of trained and untrained men. Acta physiol. scand. 1984, 122, 331-339.
59. Sahlin K, Broberg S, Ren, JM: Formation of inosine monophosphate (IMP) in human skeletal muscle during incremental dynamic exercise. Acta physiol. scand. 1989, 136, 193-198.
60. Schuback K, Essén-Gustavsson B: Muscle anaerobic response to a maximal treadmill exercise test in Standardbred trotters. Equine vet. J. 1998, 30, 504-510.
61. Sewell DA, Harris RC, Dunnett M: Carnosiue accounts for most of the variation in physico-chemical buffering in equine muscle. In: Persson SGB, Lindholm A, Jeffcott LB (eds.): Equine Exercise Physiology 3. Davis, CA, ICEEP Publications: 1991, pp 276-280.
62. Skelton MS, Kremer DE, Smith EW, Gladden LB: Lactate influx into red blood cells of athletic and nonathletic species. Am. J. Physiol. 1995, 268, R1121-R1128.
63. Snow DH, MacKenzie G: Some metabolic effects of maximal exercise in the horse and adaptations with training. Equine vet. J. 1977, 9, 134-140.
64. Snow DH, Harris RC, Gash SP: Metabolic response of equine muscle to intermittent maximal exercise. J. appl. Physiol. 1985, 58, 1689-1697.
65. Stevenson RW, Mitchell DR, Hendrick GK, Rainey R, Cherrington AD, Frizzell RD: Lactate as substrate for glycogen resynthesis after exercise. J. appl. Physiol. 1987, 62, 2237-2240.
66. Tesch PA, Daniels WL, Sharp DS: Lactate accumulation in muscle and blood during submaximal exercise. Acta physiol. scand. 1982, 114, 441-446.
67. Väihkönen LK, Heinonen OJ, Hyyppä S, Nieminen M, Pösö AR: Lactate transport activity in red blood cells of trained and untrained individuals from four racing species. Am. J. Physiol. 2001, 257, R19-R.24.
68. Väihkönen LK, Hyyppä S, Pösö AR: Factors affecting accumulation of laclate in red blood cells. Equine vet. J. 1999, Suppl. 30, 443-447.
69. Väihkönen LK, Pösö AR: Interindividual variation in total and carrier mediated lactate influx into red. blood cells. Am. J. Physiol. 1998, 274, R1121-R1128.
70. Valberg S: Metabolic response to racing and fibre properties of skeletal muscle in standardised and thoroughbred horses. J. equine vet. Sci. 1987, 7, 6-12.
71. Valberg S, Essén-Gustavsson B: Metabolic response to racing determined in pools of type I, IIA and IIB fibers. In: Gillespie JR, Robinson NE (eds): Equine Exercise Physiology 2. Davis, CA, ICEEP Publications: 1987, pp 290-301.
72. Valberg SJ, Macleay JM, Billstrom JA, Hower-Moritz MA, Mickelson JR: Skeletal muscle metabolic response to exercise in horses with 'tying-up' due to polysaccharide storage myopathy. Equine vet. J. 1999, 31, 43-47.
73. Wilson MC, Jackson VN, Heddle C, Price NT, Pilegaard H, Juel C, Bonen A, Montgomery I, Hutter OF, Halestrap AP: Lactic acid efflux from white skeletal muscle is catalyzed, by the monocarboxylate transporter isoform MCT3 (MCT4). J. biol. Chem. 1998, 273, 15920-15926.