The Possible Correlation between Activation of NF-κB/IκB Pathway and the Susceptibility of Tumor Cells to Paclitaxel-Induced Apoptosis

Oncology Research

Volumn 13, Issue 2, 2002, Pages 113-122

  Huang, Yi ^a,b   Fang, Yong ^a   Dziadyk, Jennifer M ^a   Norris, James S ^a   Fan, Weimin ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Apoptosis; Mitotic arrest; NF B I B ; Paclitaxel

Indexed keywords

ANTIMITOTIC AGENT; DNA FRAGMENT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PACLITAXEL; ANTINEOPLASTIC AGENT; CHUK PROTEIN, HUMAN; GLYCOPROTEIN P; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; MAP3K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG RESISTANCE; GENE ACTIVATION; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TUMOR CELL LINE; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE G2 PHASE; METABOLISM; MITOSIS; NEOPLASM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; G2 PHASE; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MAP KINASE KINASE KINASE 1; MITOSIS; NEOPLASMS; NF-KAPPA B; P-GLYCOPROTEIN; PACLITAXEL; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 0036357501     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Wani, M. C.; Talor, H. L.; Wall, M. E.; Coggon, P.; McPhail, A. T. Plant antitumor agents. VI. The isolation and structure of paclitaxel, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 93:2325-2327; 1971.
2. Holmes, F. A.; Walters, R. S.; Theriault, R. L.; Forman, A. D.; Newton, L. K.; Raber, M. N.; Buzdar, A. U.; Frey, D. K.; Horrtobagyi, G. N. Phase II trial of Taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst. 83:1797-1805; 1991.
3. Tishler, R. B.; Geard, C. R.; Hall, E. J.; Schiff, P. B. Taxol sensitizes human astrocytoma cells to radiation. Cancer Res. 52:3495-3497; 1992.
4. Schiff, P. B.; Frant, J.; Horwitz, S. B. Promotion of microtubule assembly in vitro by Taxol. Nature 22:665-667; 1979.
5. Rowinsky, E. K.; Cazenave, L. A.; Donehower, R. C. Taxol: A novel investigational antimicrotubule agent. J. Natl. Cancer Inst. 82:1247-1259; 1990.
6. Williams, G. T.; Smith, C. A. Molecular regulation of apoptosis: Genetic control on cell death. Cell 74:777-779; 1993.
7. Willingham, M. C.; Bhalla, K. Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis. J. Histochem. Cytochem. 42:441-450; 1994.
8. Fan, W.; Everett, E. T.; Tang, C.; Cooper, T.; Fang, Q.; Bhalla, K.; Norris, J. S. Glucocorticoid-mediated inhibition of paclitaxel-induced apoptosis in leiomyosarcoma cells. Cell. Pharmacol. 1:205-212; 1994.
9. Cheng, L.; Zheng, S.; Raghunathan, K.; Priest, D. G.; Willingham, M. C.; Norris, J. S.; Fan, W. Characterizations of paclitaxel-induced apoptosis and altered gene expression in human breast cancer cells. Cell. Pharmacol. 2:249-257; 1995.
10. Fan, W.; Cheng, L. R.; Norris, J. S.; Willingham, M. C. Glucocorticoids selectively inhibit paclitaxel-induced apoptosis in a human breast cancer cell line. Cell. Pharmacol. 3:435-440; 1996.
11. Bhalla, K.; Ibrado, A. M.; Tourkina, E.; Tang, C.; Mahonery, M. E.; Huang, Y. Taxol-induced internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 7:563-568; 1993.
12. Fan, W.; Schandl, C. A.; Cheng, L.; Norris, J. S.; Willingham, M. C. Glucocorticoids modulate taxol cytotoxicity in human solid tumor cells. Cell. Pharmacol. 3:343-348; 1996.
13. Fan, W. Possible mechanism of paclitaxel-induced apoptosis [commentary]. Biochem. Pharmacol. 57:1215-1221; 1999.
14. Torres, K.; Horwitz, S. B. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res. 58:3620-3626; 1998.
15. Jordan, M. A.; Toso, R. J.; Thrower, D.; Wilson, L. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations. Proc. Natl. Acad. Sci. USA 90(20):9552-9556; 1993.
16. Haldar, S.; Jena, N.; Croce, C. M. Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA 92:4507-4511; 1995.
17. Strober, T.; Swanson, L.; Korsmeyer, S.; Cannistra, S. A. BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc. Natl. Acad. Sci. USA 90:14094-14099; 1996.
18. Wahl, A. F.; Donaldson, K. L.; Fairchild, C.; Lee, F. Y.; Foster, S. A.; Demers, G. W.; Galloway, D. A. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nat. Med. 2:72-79; 1996.
19. Blagosklonny, M. V.; Schulte, T. W.; Nguyen, P.; Mimnaugh, E. G.; Trepel, J.; Neckers, L. Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res. 55:4623-4626; 1995.
20. Dragunow, M.; Preston, K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res. Rev. 21:1-28; 1995.
21. Huang, Y.; Johnson, K. R.; Norris, J. S.; Fan, W. NF-κB/IκB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432; 2000.
22. Brown, K.; Park, S.; Kanno, T.; Franzoso, G.; Siebenlist, U. Mutual regulation of the transcriptional activator NF-κB and its inhibitor IκB-α. Proc. Natl. Acad. Sci. USA 90:2532-2536; 1993.
23. Baeuerle, P. A. The inducible transcription factor NF-κB: Regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63-80; 1991.
24. Ryan, K. M.; Ernst, M. K.; Rice, N. R.; Vousden, K. H. Role of NF-κB in p53-mediated programmed cell death. Nature 404:892-896; 2000.
25. Wang, T. T.; Phang, J. Effects of estrogen on apoptotic pathways in human breast cancer line MCF7. Cancer Res. 55:2487-2489; 1995.
26. Sestili, M. A.; Norris, J. S.; Lipschultz, L. I.; Smith, R. G. Dunning adenocarcinoma in tissue culture: Isolation of clonal cell line, R3227H-G8-A1. J. Urol. 127:823-825; 1982.
27. Nicoletti, I.; Migliorati, G.; Pagliacci, M. C.; Grignani, F.; Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271-279; 1991.
28. Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284:309-313; 1999.
29. May, M. J.; Ghosh, S. IκB kinase: Kinsmen with different crafts. Science 284:271-273; 1999.
30. Rothwarf, D. M.; Zandi, E.; Natoli, G.; Karin, M. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395:297-300; 1998.
31. Janicke, R. U.; Ng, P.; Sprengart, M. L.; Porter, A. G. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J. Biol. Chem. 273(25):5540-15545; 1998.
32. Okano, J. I.; Rustgi, A. K. Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery. J. Biol. Chem. 276:19555-19564; 2001.
33. Ibrado, A. M.; Liu, L.; Bhalla, K. Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells. Cancer Res. 57:1109-1115; 1997.
34. Ding, A. H.; Porteu, F.; Sanchez, E.; Nathan, C. F. Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 248:370-372; 1990.
35. Matthews, J. R.; Hay, R. T. Regulation of the DNA binding activity of NF-κB. Int. J. Biochem. Cell Biol. 27:865-879; 1995.
36. Baeuerle, P.; Baltimore, D. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 53:211-217; 1988.
37. Brown, K.; Gerstberg, S.; Carlson, L.; Franzoso, G.; Siebenlist, U. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485-1488; 1995.
38. Traenckner, E. B. M.; Pahl, H. L.; Henkel, T.; Schmidt, K. N.; Wilk, S.; Baeuerle, P. A. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J. 14:2876-2833; 1995.
39. Yan, M.; Dai, T.; Deak, J. C.; Kyriakis, J. M.; Zon, L. I.; Woodgett, J. R.; Templeton, D. J. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798-800; 1994.
40. Shiah, S.; Chuang, S.; Kuo, M. Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. Mol. Pharmacol. 59:254-262; 2001.
41. MacKeigan, J. P.; Collins, T. S.; Ting, J. P. Y. MEK inhibition enhances paclitaxel-induced tumor apoptosis. J. Biol. Chem. 275:38953-38956; 2000.