Nicotinamide prevents N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats and C57BL mice

Experimental Eye Research

Volumn 74, Issue 3, 2002, Pages 383-392

  Kiuchi, Katsuji ^a   Yoshizawa, Katsuhiko ^b   Shikata, Nobuaki ^a   Matsumura, Miyo ^a   Tsubura, Airo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

7 methyldeoxyguanosine; Apoptosis; N methyl N nitrosourea; Nicotinamide; Nicotinamide adenine dinucleotide; Photoreceptor cell; Poly (ADP ribose); Poly (ADP ribose) polymerase; Retinal degeneration; Retinitis pigmentosa

Indexed keywords

7 METHYLDEOXYGUANOSINE; GUANOSINE DERIVATIVE; METHYLNITROSOUREA; NICOTINAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DOSE TIME EFFECT RELATION; DRUG EFFECT; EYE PROTECTION; FEMALE; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; SPECIES COMPARISON;

EID: 0036353980     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2001.1127     Document Type: Article

References (51)

1. Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse
2. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischaemia in Wistar rats
3. Nicotinamide, a missing link in the early stress response in eukaryotic cells: A hypothesis with special reference to oxidative stress in plants
4. Retinitis pigmentosa: The Friedenwald lecture
5. Poly (ADP-ribosyl) ation, a DNA damagedriven protein modification and regulator of genomic instability
6. DNA strand breaks. NAD metabolism, and programmed cell death
7. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
8. Caspase inhibitors block the retinal ganglion cell death following optic nerve transection
9. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations
10. (ADP-ribose)n participates in DNA excision repair
11. Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
12. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
13. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
14. Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
15. Theory and practice of nicotinamide trials in pre-type I diabetes
16. The effect of nicotinamide on cerebral circulation
17. Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats
18. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases
19. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
20. Inhibition of CPP32-1ike proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
21. + prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide
22. The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina
23. N-methyl-D-aspartate (NMDA)-induced apoptosis in rat retina
24. Nerve growth factor delays retinal degeneration in C3H mice
25. Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
26. Apoptosis in retinitis pigmentosa
27. Melatonin delays photoreceptor degeneration in the rds/rds mouse
28. Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death
29. Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s344ter during photoreceptor degeneration
30. Poly (ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
31. Histopathology of the human retina in retinitis pigmentosa
32. Increased brain NAD prevents neuronal apoptosis in vivo
33. Pigmentary degeneration induced by N-methyl-N-nitrosourea and the fate of pigment epithelial cells in the rat retina
34. Photoreceptor apoptosis induced by a single systemic administration of N-methyl-N-nitrosourea in the rat retina
35. Age-specific and dose-dependent retinal dysplasia and degeneration induced by a single intraperitoneal administration of N-methyl-N-nitrosourea to rats
36. 57BL mice
37. Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification
38. Changes of DNA repair mechanisms during the aging of the rat
39. Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice
40. Light-induced damage in the retina: Differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation
41. The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat
42. Retinal degeneration induced by N-methyl-N-nitrosourea in Syrian golden hamsters
43. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro
44. Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting
45. tm1 mice by an apoptosis suppressor gene
46. Phylogenetic and ontogenetic study of retinal lesions induced by N-methyl-N-nitrosourea in animals
47. Retinitis pigmentosa: Defined from a molecular point of view
48. Mechanisms of photoreceptor cell apoptosis induced by N-methyl-N-nitrosourea in Sprague-Dawley rats
49. Caspase-3 inhibitor rescues N-methyl-N-nitrosourea-induced retinal degeneration in Sprague-Dawley rats
50. N-methyl-N-nitrosourea-induced photoreceptor apoptosis in the mouse retina
51. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity