Functional characterization of a novel serotonin receptor (5-HTap2) expressed in the CNS of Aplysia californica

Journal of Neurochemistry

Volumn 80, Issue 2, 2002, Pages 335-345

  Barbas, Demian ^a,b   Zappulla, Jacques P ^a,b   Angers, Stéphane ^a   Bouvier, Michel ^a   Castellucci, Vincent F ^a   DesGroseillers, Luc ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Adenylyl cyclase inhibition; Aplysia californica; Bag cells; CNS; G protein coupled receptor; Serotonin

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; ADENYLATE CYCLASE; CLOZAPINE; G PROTEIN COUPLED RECEPTOR; KETANSERIN; METERGOLINE; METITEPINE; PIPERAZINE DERIVATIVE; RECEPTOR SUBTYPE; RNA; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN RECEPTOR;

AMINO ACID SEQUENCE; APLYSIA; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; EGG LAYING; EMBRYO; GENE AMPLIFICATION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; LYMNAEA; MOLECULAR CLONING; NEUROMODULATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SEQUENCE HOMOLOGY;

ACTION POTENTIALS; ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; APLYSIA; CLONING, MOLECULAR; COS CELLS; CYCLIC AMP; GENE EXPRESSION; GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; NEURONS; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN; SIGNAL TRANSDUCTION; SYNAPSES; TRITIUM;

APLYSIA; APLYSIA CALIFORNICA; INVERTEBRATA; LYMNAEA; LYMNAEA STAGNALIS; MAMMALIA;

EID: 0036327928     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00703.x     Document Type: Article

References (52)

1. Cloning and functional expression of an Aplysia 5-HT receptor negatively coupled to adenylate cyclase
2. 4 receptor desensitization in colliculi neurons
3. Molecular and cellular regulation of neuropeptide expression: The bag cell model system
4. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
5. Facilitatory transmitter causes a selective and prolonged increase in adenosine 3′:5′-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia
6. G-protein coupled receptors: Models, mutagenesis, and drug design
7. Molecular tinkering of G protein-coupled receptors: An evolutionary success
8. Molecular biology of 5-HT receptors
9. Regulation of synthesis of the neurosecretory egg-laying hormone of Aplysia: Antagonistic roles of calcium and cyclic adenosine 3′:5′-monophosphate
10. Serotonin receptors in cognitive behaviors
11. 1B receptors in the rat
12. Pre-synaptic facilitation revisited: State and time dependence
13. Serotonergic modulation of cholinergic function in the central nervous system: Cognitive implications
14. A novel strategy for the immunological tagging of cDNA constructs
15. Antiproliferative effects of antisense oligonucleotides directed to the RNA of c-myc oncogene
16. Molecular aspects of egg-laying behavior in Aplysia californica
17. A novel actin cDNA is expressed in the neurons of Aplysia californica
18. 3H]LSD binding and adenylate cyclase stimulation
19. i coupling
20. Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons
21. Functional characteristics of heterologously expressed 5-HT receptors
22. On the transmitter function of 5-hydroxytryptamine at excitatory and inhibitory monosynaptic junctions
23. Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons
24. The cellular basis of classical conditioning in Aplysia californica: It's less simple than you think
25. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation
26. Structural and functional conservation of serotonin receptors throughout evolution
27. Serotonergic inhibition of afterdischarge in peptidergic bag cells
28. 2-adrenergic receptors
29. Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites
30. 125I]lyseric acid diethylamide binding to serotonin receptors in Aplysia
31. Peptidergic neurons of Aplysia lose their response to cyclic adenosine 3′:5′-monophosphate during a prolonged refractory period
32. Alpha bag cell peptide directly modulates the excitability of the neurons that release it
33. ras
34. Oligomerization of dopamine and serotonin receptors
35. Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase C
36. MAP kinase translocates into the nucleus of the pre-synaptic cell and is required for long-term facilitation in Aplysia
37. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory
38. A common step for signal transduction in G protein-coupled receptors
39. Diverse signalling by 5-hydroxytryptamine (5-HT) receptors
40. A genetic switch for long-term memory
41. Antagonists of cholinergic and serotoninergic responses of Aplysia buccal muscle
42. Alpha-bag cell peptide inhibits bag cell adenylate cyclase via a GTP-dependent mechanism
43. A highly sensitive adenylate cyclase assay
44. The synaptic junctions of LE and RF cluster sensory neurones of Aplysia californica are differentially modulated by serotonin
45. Neuronal sites of action of a neurosecretory peptide, egg-laying hormone in Aplysia californica
46. Serotonin receptor cDNA cloned from Lymnaea stagnalis
47. Differential distribution of functional receptors for neuromodulators evoking short-term heterosynaptic plasticity in Aplysia sensory neurons
48. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
49. Structure and function of invertebrate 5-HT receptors: A review
50. Long-term alterations induced by injury and by 5-HT in Aplysia sensory neurons: Convergent pathways and common signals?
51. A bradykinin-like neuropeptide precursor gene is expressed in neuron L5 of Aplysia californica
52. 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes