Non-polarized distribution of synaptotagmin IV in neurons: Evidence that synaptotagmin IV is not a synaptic vesicle protein

Neuroscience Research

Volumn 43, Issue 4, 2002, Pages 401-406

  Ibata, Keiji ^b   Hashikawa, Tsutomu ^c   Tsuboi, Takashi ^d   Terakawa, Susumu ^d   Liang, Fengyi ^c   Mizutani, Akihiro ^a   Fukuda, Mitsunori ^c   Mikoshiba, Katsuhiko ^c  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e RIKEN   (Japan)

Author keywords

Depolarization; Golgi; Immediate early genes; Neuronal development; Synaptic plasticity; Synaptotagmin

Indexed keywords

SYNAPTOTAGMIN; SYNAPTOTAGMIN IV; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL FRACTIONATION; CELL MEMBRANE TRANSPORT; CELL ORGANELLE; CONTROLLED STUDY; DENDRITE; ELECTRON MICROSCOPY; FLUORESCENCE; GOLGI COMPLEX; HIPPOCAMPUS; MOUSE; NEOCORTEX; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

ANIMALS; ANIMALS, NEWBORN; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICROSCOPY, ELECTRON; NEOCORTEX; NERVE TISSUE PROTEINS; NEURONS; SUBCELLULAR FRACTIONS; SYNAPTIC VESICLES; SYNAPTOTAGMINS; TISSUE DISTRIBUTION;

EID: 0036315816     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00066-4     Document Type: Article

References (35)

1. Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the CNS
2. Synaptotagmin I and IV define distinct populations of neuronal transport vesicles
3. The subcellular localizations of atypical synaptotagmins III and VI
4. Genomic analysis of synaptotagmin genes
5. Biogenesis of regulated exocytotic carriers in neuroendocrine cells
6. Deficits in memory and motor performance in synaptotagmin IV mutant mice
7. Synaptotagmin I functions as a calcium regulator of release probability
8. The function of inositol high polyphosphate binding proteins
9. A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain: Implications for distinct functions of the two isoforms
10. Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)
11. Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II
12. Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X
13. A unique spacer domain of synaptotagmin IV is essential for Golgi localization
14. Alternative splicing isoforms of synaptotagmin VII in the mouse, rat, and human
15. A third synaptotagmin gene, Syt3, in the mouse
16. Synaptotagmin IV is present at the Golgi and distal parts of neurites
17. Membrane fusion and exocytosis
18. Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells
19. Fast, convenient, and effective method to transiently transfect primary hippocampal neurons
20. Mechanisms of synaptic vesicle exocytosis
21. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
22. Synaptotagmins in membrane traffic: Which vesicles do the tagmins tag
23. 2+-dependent exocytosis of lysosomes in fibroblasts
24. Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal
25. PEF-BOS, a powerful mammalian expression vector
26. Roles of synaptotagmin C2 domains in neurotransmitter secretion and inositol high-polyphosphate binding at mammalian cholinergic synapses
27. Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis
28. The diversity of Rab proteins in vesicle transport
29. Synaptotagmins: More isoforms than functions
30. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
31. Molecular machinery mediating vesicle budding, docking and fusion
32. Synaptotagmins: Why so many
33. 2+ sensor in exocytosis
34. Functional and biochemical analysis of the C2 domains of synaptotagmin IV
35. Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain