The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions

Journal of Virology

Volumn 76, Issue 16, 2002, Pages 8079-8089

  Hakata, Yoshiyuki ^a   Yamada, Masami ^a   Mabuchi, Naoto ^a   Shida, Hisatoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1; GAG PROTEIN; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; RAN PROTEIN; REV PROTEIN; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; DIMERIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; OLIGOMERIZATION; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROVIRUS; RNA TRANSPORT; TRANSACTIVATION; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; BASE SEQUENCE; BINDING SITES; CYTOPLASM; DIMERIZATION; GENE PRODUCTS, REV; GENES, VIRAL; HELA CELLS; HIV-1; HUMANS; KARYOPHERINS; PLASMIDS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; RNA, VIRAL; SEQUENCE DELETION; TRANSFECTION; VIRUS REPLICATION;

EID: 0036311895     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.16.8079-8089.2002     Document Type: Article

References (60)

1. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
2. Dominant negative mutants of human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo
3. Sensitive in vitro analysis of HIV-1 Rev multimerization
4. The human immunodeficiency virus rev protein is a nuclear phosphoprotein
5. Identification of sequences important in the nucleolar localization of buman immunodeficiency virus Rev: Relevance of nucleolar localization to function
6. Solution oligomerization of the Rev protein of HIV-1: Implications for function
7. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
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9. Regulation of human immunodeficiency virus replication
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12. Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro
13. Biochemical characterization of binding of multiple HIV-1 Rev monomeric proteins to the Rev responsive element
14. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization
15. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA
16. Rev protein of human immunodeficiency virus type I affects the stability and transport of the vital MRNA
17. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
18. Unique response pathways are established by allosteric interactions among nuclear hormone receptors
19. CRMI is an export receptor for leucine-rich nuclear export signals
20. Interaction of HTLV-1 Taxi with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes
21. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
22. Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus
23. Rat CRM1 is responsible for the poor activity of human T-cell leukemia virus type 1 Rex protein in rat cells
24. Involvement of human CRM1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type 1
25. Regulation of human immunodeficiency virus env expression by the rev gene product
26. Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev transactivator
27. Phosphorylation of the rev gene product of human immunodeficiency virus type 1
28. HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region
29. A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells
30. Effector domains of human immunodeficiency virus type 1 Rev and human T cell leukemia virus type 1 Rex are functionally interchangeable and share an essential peptide motif
31. trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes
32. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev trans activator: Mapping cryptic functions of the arginine-rich motif
33. Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein
34. Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deduced from analysis of assembly-defective mutants
35. The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments
36. Effects of translation initiation factor elF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding
37. Two distinct pathways for intronless mRNA expression: One related, the other unrelated to human immunodeficiency virus Rev and human T cell leukemia virus type I Rex functions
38. Sequence requirements for Rev multimerization in vivo
39. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency
40. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain
41. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence
42. Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function
43. A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-I late gene expression
44. Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells
45. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm
46. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
47. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
48. Evidence for a role of CRM1 in signal-mediated nuclear protein export
49. CRM1-mediated recycling of snurportin 1 to the cytoplasm
50. HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm
51. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
52. A second post-transcriptional trans-activator gene required for HTLV-III replication
53. Exportin 1 (Crm1p) is an essential nuclear export factor
54. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: Transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm
55. Oligomerization of HIV-1 Rev mutants in the cytoplasm and during nuclear import
56. Co-expression of a trans-dominant negative mutant of the human immunodeficiency virus type 1 (HIV-1) Rev protein affects the Rev-dependent splicing pattern and expression of HIV-1 RNAs
57. SRα promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
58. Functional analysis of the human immunodeficiency virus type 1 Rev protein oligomerization interface
59. Identification of a signal for rapid export of proteins from the nucleus
60. Sequence-specific RNA binding by the HIV-1 Rev protein