Introduction of the carbohydrate-activated promoter PmalK for recombinant protein production

Applied Microbiology and Biotechnology

Volumn 59, Issue 2-3, 2002, Pages 231-238

  Bostrom M ^a   Larsson, Gen ^a  

^a Stockholm C P Astron/Biotechnol   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CARBOHYDRATE; GLUCOSE; MALTOSE; RECOMBINANT PROTEIN;

BIOTECHNOLOGY; PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL DENSITY; CONTROLLED STUDY; CYTOPLASM; DILUTION; FED BATCH REACTOR; FEEDING; NONHUMAN; PROMOTER REGION;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CYCLIC AMP; MALTOSE; OPERON; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS;

EID: 0036310664     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-002-1000-1     Document Type: Article

References (28)

1. Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification
2. Maltose/maltodextrin system of Escherichia coli: Transport, metabolism, and regulation
3. Maltose transacetylase of Escherichia coli
4. Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation
5. In vitro gene fusions that join an enzymically active β-galactosidase segment to amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals
6. Metabolic approaches for the optimisation of recombinant fermentation processes
7. Maltose and maltotriose can be formed endogenously in Escherichia coli from glucose and glucose-1-phosphate independently of the enzymes of the maltose system
8. Negative transcriptional regulation of a positive regulator: The expression of malT, encoding the transcriptional activator of the maltose regulon of Escherichia coli, is negatively controlled by Mlc
9. The role of the trehalose system in regulation the maltose regulon of Escherichia coli
10. Adaption to life at micromolar nutrient levels: The regulation of Escherichia coli glucose transport by endoinduction and cAMP
11. Regulation by nutrient limitation
12. Growth of bacterial cultures 50 years on: Towards an uncertainty principle instead of constants in bacterial growth
13. Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E.coli lac repressor in monkey cells
14. Strategies for optimizing heterologous protein expression in Escherichia coli
15. Rapid sampling, cell inactivation and evaluation of low extracellular glucose concentrations during fed-batch cultivation
16. Is Escherichia coli growing in glucose-limited chemostat culture able to utilize other sugars without lag?
17. Strategies for achieving high-level expression of genes in Escherichia coli
18. Differential expression of mal genes under cAMP and endogenous inducer control in nutrient-stressed Escherichia coli
19. Supercoiling is essential for the formation and stability of the initiation complex at the divergent malEp and malKp promoters
20. CRP induces the repositioning of MalT at the Escherichia coli malKp promoter primarily through DNA bending
21. Artificial promoters for metabolic optimization
22. Control and optimisation of cellular bottlenecks
23. Alternative regulation principles for the production of recombinant proteins in Escherichia coli
24. The growth of Escherichia coli in glucose-limited chemostat cultures: A re-examination of the kinetics
25. Advances in Escherichia coli production of therapeutic proteins
26. s and ppGpp in glucose-limited fed-batch and continuous cultures of Escherichia coli
27. Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response