Metabolic approaches for the optimisation of recombinant fermentation processes

Applied Microbiology and Biotechnology

Volumn 53, Issue 1, 1999, Pages 43-50

  Cserjan Puschmann, M ^a   Kramer, W ^a   Duerrschmid, E ^a   Striedner, G ^a   Bayer, K ^a  

^a UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL METABOLISM; ESCHERICHIA COLI; FERMENTATION; GENETIC RECOMBINATION; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMID; PROTEIN SYNTHESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0033490213     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051612     Document Type: Article

References (33)

1. Bayer K, Jungbauer A, Kramer W, Lettner H, Schönhofer W, Skias M, Steindl F, Taferner N, Uhl, K (1990) Humane rekombinante Superoxiddismutase. BioEngineering 6: 24-30
2. Bentley WE, Mirjalili N, Andersen DC, Davis RH, Kompala DS (1990) Plasmid encoded protein: the principal factor in the "metabolic burden" associated with recombinant bacteria. Biotechnol Bioeng 35: 668-6 81
3. Breuer S, Marzban G, Cserjan-Puschmann M, Dürrschmid E, Bayer K (1998) Off-line quantitative monitoring of plasmid copy number in bacterial fermentation by capillary electrophoresis. Electrophoresis 19: 2474-24 78
4. Brugidou C, Rocher A, Giraud E, Lelong B, Marin B, Raimbault M (1991) A new HPLC technique for separation and determination of adenylic and nicotinamide nucleotides in Lactobacillus plantarum. Biotechnol Technol 5: 475-4 78
5. Cashel M, Rudd KE (1987) The stringent response. In: Neidhardt FC, Ingraham JL, Brooks Low K, Magasanik B, Schächter M, Umbarger H (eds) Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, DC pp 1410-14 38
6. Das A (1990) Overproduction of proteins in E. coli: vectors, hosts and strategies. Methods Enzymol 182: 96-1 12
7. Federn H, Ristow H (1986) Isolation of standard-, deoxy-and highly phosphorylated nucleotides from Bacillus brevis and their separation by ion-pair high-performance liquid chromatography. Chromatographia 22: 287-2 91
8. George H, Powell A, Dahlgren M, Herber W, Maignetter R, Burges B, Stirdivants S, Greasham R (1992) Physiological effects of TGFa-PE40 expression in recombinant E. coli JM109. Biotechnol Bioeng 40: 437-4 45
9. Glick BR (1995) Metabolic load and heterologous gene expression. Biotechnol Adv 13: 247-2 61
10. Hecker M, Riesenberg D (1988) Hochphosphorylierte Guaninnukleotide. In: Hecker M, Babel W (eds) Physiologie der Mikroorganismen. Fischer, Stuttga rt
11. Hjorth R, Ryser S, Pühler A, Diderichsen B (1992) Made by genetic engineering No. 3. Biotech-Forum Europe (BFE) 9: 641-6 42
12. Imanak T (1986) Application of recombinant DNA technology to the production of useful biomaterials. Adv Biochem Eng Biotechnol 33: 1-27
13. Jensen E, Carlsen S (1990) Production of recombinant human growth hormone in E. coli expression of different precursors and physiological effects of glucose, acetate and salts. Biotechnol Bioeng 36: 1-11
14. Kramer W, Elmecker G, Weik R, Mattanovich D, Bayer K (1996) Kinetic studies for the optimisation of recombinant protein formation. Ann NY Acad Sci 782: 323-3 33
15. Lengeler JW, Postma PW (1999) Global regulatory networks and signal transduction pathways. In: Lengeler JW, Drews G, Schlegel HG (eds) Biology of the prokaryotes. Georg Thieme Verlag, Stuttgart, Germany pp 491-5 23
16. Little R, Bremer H (1982) Quantitation of guanosine 5′,3′-bisdi-phosphate in extracts from bacterial cells by ion-pair reversed-phase high-performance liquid chromatography. Anal Biochem 126: 381-38 8.
17. Lundin A, Thore A (1975) Comparison of methods for extraction of bacterial adenine nucleotides determined by firefly assay. Appl Microbiol 30: 713-7 21
18. Lüttich C (1991) Stammverbesserung an rekombinanten, humane Superoxiddismutase produzierenden E. coli. Diplomarbeit, Universität für Bodenkultur, Vien na
19. Meyer R, Wagner KG (1985) Determination of nucleotide pools in plant tissues by high-performance liquid chromatography. Anal Biochem 148: 269-2 76
20. Mueller MM (1995) In-vitro Synthese und Reinigung von Guanosintetraphosphat. Diplomarbeit, Universität für Bodenkultur, Vien na
21. Mueller RH, Loffhagen N, Babel W (1996) Rapid extraction of (di)nucleotides from bacterial cells and determination by ion-pair reversed phase HPLC. J Microbiol Methods 25: 29-35
22. Neidhardt FC, Ingraham JL, Schaechter M (1990) Regulation of gene expression: multigene systems and global regulation In: Physiology of the bacterial cell. Sinauer Sunderland, Mass., pp 351-3 88
23. Payne SM, Ames BN (1982) A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells. Anal Biochem 123: 151-1 61
24. Perret D (1986) Nucleotides, nucleosides and bases In: Lim CK (ed) HPLC of small molecules. IRL Press, Oxford, pp 221-2 59
25. Ryll T, Wagner R (1991) Improved ion-pair high-performance liquid chromatographic method for the quantification of a wide variety of nucleotides and sugar-nucleotides in animal cells. J Chromatogr 570: 77-88
26. Rymaszewski Z, Aplanalp WA, Cohen RM, Chomczynski P (1990) Estimation of cellular DNA content in cell lysates suitable for RNA isolation. Anal Biochem 188: 91-96
27. Stocchi V, Cucchiarini L, Magnani M, Chiarantini L, Crescentini G (1985) Simultaneous extraction and reversed phase high performance liquid chromatography determination of adenine and pyridine nucleotides in human red blood cells. Anal Biochem 146: 118-1 24
28. Studier FW, Moffat BA (1986) Use of the bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol 189: 113-1 30
29. Studier FW, Rosenberg AL, Dunn JJ, Dubendorff JW (1990) Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol 185: 60-89
30. Wróbel B, Wegrzyn G (1998) Replication regulation of ColE1-like plasmids in amino acid-starved Escherichia coli. Plasmid 39: 48-62
31. Xiao H, Kalman M, Ikehara K, Zemel S, Glaser G, Cashel M (1991) Residual guanosine 3′,5′-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J Biol Chem 266: 5980-59 90
32. Yanisch-Perron C, Vieira J, Messing J (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103-1 19
33. Yee L, Blanch HW (1992) Recombinant protein expression in high cell density fed-batch cultures of E. coli. Bio/Technology 10: 1550-155 6