Daxx-mediated accumulation of human cytomegalovirus tegument protein pp71 at ND10 facilitates initiation of viral infection at these nuclear domains

Journal of Virology

Volumn 76, Issue 15, 2002, Pages 7705-7712

  Ishov, Alexander M ^a   Vladimirova, Olga V ^a   Maul, Gerd G ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DAXX PROTEIN; PROTEIN ND10; PROTEIN PP71; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; INTEGUMENT; KNOCKOUT GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN INTERACTION; TRANSACTIVATION; VIRUS GENOME; VIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; COS CELLS; CYTOMEGALOVIRUS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NUCLEAR PROTEINS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 0036310441     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.15.7705-7712.2002     Document Type: Article

References (37)

1. Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML
2. Human cytomegalovirus tegument protein pp71 (ppUL82) enhances the infectivity of viral DNA and accelerates the infectious cycle
3. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
4. Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblasts
5. UL82 virion protein activates expression of immediate early viral genes in human cytomegalovirus-infected cells
6. Transcriptional regulation of the human cytomegalovirus US11 early gene
7. Induction of the PML protein by interferons in normal and APL cells
8. Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus
9. An essential role for daxx in the inhibition of B lymphopoiesis by type I interferons
10. Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Sp100 and promyelocytic leukemia protein (PML)
11. Intracellular localization and expression of the human cytomegalovirus matrix phosphoprotein pp71 (ppUL82): Evidence for its translocation into the nucleus
12. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx
13. Activation of herpesvirus gene expression by the human cytomegalovirus protein pp71
14. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition
15. PML is critical for ND10 formation and recruits the PML-interacting protein Daxx to this nuclear structure when modified by SUMO-1
16. Human cytomegalovirus immediate early interaction with host nuclear structures: Definition of an immediate transcript environment
17. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region
18. The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1
19. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML
20. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
21. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
22. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements
23. Nuclear domain 10, the site of DNA virus transcription and replication
24. Review: Properties and assembly mechanisms of ND1O, PML bodies, or PODs
25. Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress
26. The Daxx enigma
27. Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot
28. Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins
29. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death
30. Herpes simplex viruses and their replication
31. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing
32. Human cytomegalovirus induced inhibition of hematopoietic cell line growth is initiated by events taking place before translation of viral gene products
33. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element
34. Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product
35. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression
36. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
37. Role of SUMO-1-modified PML in nuclear body formation