Supersensitivity of the cholinergic muscarinic system in the rat's brain is induced by high concentrations of Cu+2

Investigacion Clinica

Volumn 43, Issue 2, 2002, Pages 107-117

  Gutiérrez Reyes, Elsa ^a   Castañeda Perozo, Darwin ^a   Papale Centofanti, Jhan ^a   Nello Pérez, Carlota ^a   Pascuzzo Lima, Carmine ^a   Moreno Yanez, José ^a   Bonfante Cabarcas, Rafael ^a  

^a UNIVERSIDAD CENTROCCIDENTAL LISANDRO ALVARADO   (Venezuela)

Author keywords

3H QNB binding; Cu2+; Locomotor activity; Memory; Muscarinic receptor; Super sensitivity

Indexed keywords

COPPER; MUSCARINIC RECEPTOR; PENICILLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BEHAVIOR; BRAIN; BRAIN CORTEX; BRAIN REGION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; MALE; MEMORY; NONHUMAN; RAT; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; ATROPINE; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHELATING AGENTS; CHOLINERGIC FIBERS; COPPER SULFATE; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; NERVE TISSUE PROTEINS; PENICILLAMINE; PYRIDOXINE; QUINUCLIDINYL BENZILATE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; ZINC SULFATE;

EID: 0036309958     PISSN: 05355133     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): High throughput assays in mammalian cells
2. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
3. Delineating MR functions
4. The cholinergic hypothesis of geriatric memory dysfunction
5. Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence
6. Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: A review of immunocytochemical localization in relation to learning and memory
7. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease
8. Testing the NMDA, long-term potentiation, and cholinergic hypothesis of spatial learning
9. Evidence for an endogenous factor interfering with antagonist binding at the muscarinic cholinergic receptor
10. Partial characterization of endogenous modulators of muscarinic acetylcholine receptors in human frontal cortex
11. Guanine nucleotide regulation of a mammalian myocardial MR system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting
12. Efecto regulador del cobre sobre la función muscarínica del cerebro humano
13. The role of copper in neurodegenerative disease
14. 2+ imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress
15. 3H]cismethyldioxolane binding to guanyl nucleotide-sensitive sites
16. Effects of copper on the binding of agonists and antagonists to MRs in rat brain
17. Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain
18. Copper ions and diamide induce a high affinity guanine-nucleotide-insensitive state for muscarinic agonists
19. Copper-induced alteration of muscarinic binding in bovine adrenal medulla
20. Characterization of muscarinic cholinergic receptors in the brains of copper-deficient rats
21. Alterations in neurotransmitter receptor binding in discrete areas of the copper-deficient rat brain
22. Receptor-binding changes in copperdeficient rats
23. Measurement of protein using Bicinchoninic Acid
24. Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention
25. A study of methods for the determination of lead and cadmium
26. Histochemical detection of zinc and copper in various neurons of the central nervous system
27. 2+, iron and copper in suckling and adult rat brains
28. Effect of manganese and copper interaction on behavior and biogenic amines in rats fed a 10% casein diet
29. Neurochemical changes in rats coexposed to lead and copper
30. Effects of heavy metals on monoamine uptake and release in brain synaptosomes and blood platelets
31. Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2
32. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonistpromoted downregulation
33. The cysteine of the cytoplasmic tail of glucose-dependent insulinotropic peptide receptor mediates its chronic desensitization and down-regulation
34. Identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the hamster alpha (1B)-adrenergic receptor
35. Metal-ion regulation of gene expression in yeast
36. Wilson disease in 1998: Genetic, diagnostic and therapeutic aspects
37. CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease
38. Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse
39. Age-dependent influence of dietary zinc restriction on short-term memory in male rats