Limitation of ribosomal protein L11 availability in vivo affects translation termination

Journal of Molecular Biology

Volumn 319, Issue 2, 2002, Pages 329-339

  Van Dyke, Natalya ^a   Xu, Wenbing ^a   Murgola, Emanuel J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

23 S rRNA fragment; Chromosomal rplK gene knockout; Nonsense suppression; Ribosomal protein L11 binding region; Translation termination

Indexed keywords

COMPLEMENTARY RNA; PROTEIN L 11; RIBOSOME PROTEIN; RIBOSOME RNA; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CODON; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION; GENE OVEREXPRESSION; IN VIVO STUDY; INHIBITION KINETICS; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION; STOP CODON; TRANSLATION REGULATION; WILD TYPE;

ESCHERICHIA COLI;

EID: 0036307983     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00304-2     Document Type: Article

References (40)

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2. The binding site for ribosomal protein L11 within 23 S ribosomal RNA of Escherichia coli
3. Ribosomal proteins EL11 from Escherichia coli and L15 from Saccharomyces cerevisiae bind to the same site in both yeast 26 S and mouse 28 S rRNA
4. The conserved GTPase center and variable region V9 from Saccharomyces cerevisiae 26 S rRNA can be replaced by their equivalents from other prokaryotes or eukaryotes without detectable loss of ribosomal function
5. Replacement of the L11 binding region within E. coli 23 S ribosomal RNA with its homologue from yeast: In vivo and in vitro analysis of hybrid ribosomes altered in the GTPase centre
6. Chimeric rRNAs containing the GTPase centers of the developmentally regulated ribosomal rRNA of Plasmodium falciparum are functionally distinct
7. Structural features of the large subunit rRNA expressed in Plasmodium falciparum sporozoites that distinguish it from the asexually expressed large subunit rRNA
8. The ribosome-in-pieces: Binding of elongation factor EF-G to oligoribonucleotides that mimic the sarcin/ricin and thiostrepton domains of 23 S ribosomal RNA
9. Chemical crosslinking of elongation factor G to the 23 S RNA in 70 S ribosomes from Escherichia coli
10. Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation
11. An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function
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13. 4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli
14. Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23 S rRNA
15. The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre
16. 4 and the antibiotic thiostrepton interact with overlapping regions of the 23 S rRNA backbone in the ribosomal GTPase centre
17. The antibiotics micrococcin and thiostrepton interact directly with 23 S rRNA nucleotides 1067A and 1095A
18. Functional sites of interactions between release factor RF1 and the ribosome
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20. The Escherichia coli ribosomal protein L11 suppresses release factor 2 but promotes the release factor 1 activities in peptide chain termination
21. Mutations in the GTPase center of Escherichia coli 23 S rRNA indicate release factor 2-interactive sites
22. Mutations in RNAs of both ribosomal subunits cause defects in translation termination
23. Mutations in conserved regions of ribosomal RNAs decrease the productive association of peptide-chain release factors with the ribosome during translation termination
24. A detailed view of a ribosomal active site: The structure of the L11-RNA complex
25. Structure of the A site of Escherichia coli 16 S ribosomal RNA complexed with an aminoglycoside antibiotic
26. Fragmentation of the ribosome to investigate RNA-ligand interactions
27. Structure of a conserved RNA component of the peptidyl transferase centre
28. Crystal structure of a conserved ribosomal protein-RNA complex
29. An rRNA fragment and its antisense can alter decoding of genetic information
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31. The RNA binding domain of ribosomal protein L11 is structurally similar to homeodomains
32. Mutants of E. coli lacking ribosomal protein L11
33. Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: Application to open reading frame characterization
34. A functional peptide encoded in the Escherichia coli 23 S rRNA
35. Release factors differing in specificity for terminator codons
36. Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner
37. tRNA, suppression, and the code
38. Mutational alteration of translational coupling in the L11 ribosomal protein operon of Escherichia coli