Mutations in the GTPase center of Escherichia coli 23S rRNA indicate release factor 2-interactive sites

Journal of Bacteriology

Volumn 184, Issue 4, 2002, Pages 1200-1203

  Xu, Wenbing ^a   Pagel, Frances T ^a   Murgola, Emanuel J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RELEASE FACTOR 2; RELEASING FACTOR; RIBOSOME RNA; TRANSLATION TERMINATION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; CODON; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; NONSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA STRUCTURE; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS; TRANSLATION REGULATION;

BINDING SITES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GTP PHOSPHOHYDROLASES; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PEPTIDE TERMINATION FACTORS; RIBOSOMAL PROTEINS; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; RRNA OPERON;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PROKARYOTA;

EID: 0036156944     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.184.4.1200-1203.2002     Document Type: Article

References (23)

1. Mutations in RNAs of both ribosomal subunits cause defects in translation termination
2. Mutations in conserved regions of ribosomal RNAs decrease the productive association of peptide-chain release factors with the ribosome during translation termination
3. An rRNA fragment and its antisense can alter decoding of genetic information
4. The requirement for ribosomal proteins L7 and L12 in peptide chain termination
5. Crystal structure of a conserved ribosomal protein-RNA complex
6. RNA tertiary structure and protein recognition in an L11-RNA complex
7. 4 pentameric complex in the GTPase domain of 23S ribosomal RNA from Escherichia coli
8. Mapping the ribosomal RNA neighborhood of protein L11 by directed hydroxyl radical probing
9. UGA suppression by a mutant RNA of the large ribosomal subunit
10. Bases defining an ammonium and magnesium ion-dependent tertiary structure within the large subunit ribosomal RNA
11. rRNA functional sites and structures for peptide chain termination
12. Variety of nonsense suppressor phenotypes associated with mutational changes at conserved sites in Escherichia coli ribosomal RNA
13. Phenotypic heterogeneity of mutational changes at a conserved nucleotide in 16S ribosomal RNA
14. Ribosomal mechanics, antibiotics, and GTP hydrolysis
15. 4 and the antibiotic thiostrepton interact with overlapping regions of the 23S rRNA backbone in the ribosomal GTPase centre
16. The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A
17. The Escherichia coli ribosomal protein L11 suppresses release factor 2 but promotes the release factor 1 activities in peptide chain termination
18. Ribosomal RNA, translocation, and elongation factor-associated GTP hydrolysis
19. A detailed view of a ribosomal active site: The structure of the L11-RNA complex
20. Cooperative interactions of RNA and thiostrepton antibiotic with two domains of ribosomal protein L11
21. Functional effects of mutating the closing G-A base-pair of a conserved hairpin loop in 23S ribosomal RNA
22. Crystal structure of the ribosome at 5.5 Å resolution