Bone effects of hexarelin, a GH-releasing peptide, in female rats: Influence of estrogen milieu

European Journal of Endocrinology

Volumn 146, Issue 6, 2002, Pages 855-862

  Sibilia, V ^a   Cocchi, D ^a   Villa, I ^a   Lattuada, N ^a   Soglian, A ^a   Rubinacci, A ^a   Muller, E E ^a   Pecile, A ^a   Netti, C ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ANESTHETIC AGENT; BIOCHEMICAL MARKER; DEOXYPYRIDINOLINE; ESTROGEN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HEXA; HEXARELIN; KETAMINE; SODIUM CHLORIDE; SOMATOMEDIN; SOMATOMEDIN C; XYLAZINE;

AGE; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; DIAPHYSIS; DRUG EFFECT; DRUG SCREENING; DRUG SENSITIVITY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; FEMALE; FEMUR; GENDER; GROWTH HORMONE RELEASE; HORMONAL REGULATION; LUMBAR VERTEBRA; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; URINALYSIS; URINARY EXCRETION;

EID: 0036306249     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1460855     Document Type: Article

References (35)

1. Secretory patterns of growth hormone according to sex and age
2. Both oral and transdermal estrogen increase growth hormone release in postmenopausal women - A clinical research center study
3. Effect of estrogen status on bone regulating hormones
4. Estrogen enhances growth hormone receptor expression and growth hormone action in rat osteosarcoma cells and human osteoblast-like cells
5. Anabolic therapy for osteoporosis
6. Effects of recombinant growth hormone (GH) treatment on bone mineral density and body composition in adults with childhood onset growth hormone deficiency
7. Neuroendocrine control of growth hormone secretion
8. Osteoporosis after oophorectomy in the mature female rat and effect of estrogen or progestrogen replacement therapy in its prevention
9. Skeletal alterations in ovariectomized rats
10. The ovariectomized rat model of postmenopausal bone loss
11. Hexarelin, a growth hormone-releasing peptide, counteracts bone loss in gonadectomized rats
12. Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3
13. Excretion of pyridinium cross-links of collagen in ovariectomized rats as urinary markers for increased bone resorption
14. Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site specific manner
15. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
16. Growth hormone stimulates bone formation and strength of cortical bone in aged rats
17. The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats
18. Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): Positive correlation with the presence of the GH-induced IGF-binding protein BP-3
19. Estrogen inhibition of periosteal bone formation in rat long bones: Down regulation of gene expression for bone matrix proteins
20. Skeletal effects of estrogen
21. Growth hormone and adult bone remodeling
22. Treatment with the oral growth hormone segretagogue MK-677 increases markers of bone formation and bone resorption in obese young males
23. Sixteen weeks of hexarelin therapy in aged dogs: Effects on somatotropic axis, muscle morphology, and bone metabolism
24. Regulation of the growth hormone-insulin-like growth factor I axis in developing and adult monkeys is affected by estradiol replacement and supplementation with insulin-like growth factor I
25. The insulin-like growth factor I generation test: Resistance to growth hormone with aging and estrogen replacement therapy
26. 2 (GHRP-6)-induced GH secretion in the rat
27. Oral estradiol administration modulates continuos intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women
28. Oestrogen replacement does not restore the reduced GH-releasing activity of hexarelin, a synthetic hexapeptide, in post-menopausal women
29. Growth hormone normalizes vertebral strength in ovariectomized rats
30. Elevated levels of growth hormone increase bone mineral content in normal young mice, but not in ovariectomized mice
31. Effects of recombinant human growth hormone and insulin-like growth factor-I with or without 17β-estradiol, on bone and mineral homeostasis of aged ovariectomized rats
32. Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats
33. Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on vertebrae in middle aged rats
34. The influence of sex and gonadectomy on the growth hormone and corticosterone response to hexarelin in the rat
35. Gender difference in growth hormone response in adults