Ca2+/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan

Biochemical Journal

Volumn 357, Issue 3, 2001, Pages 843-850

  Lewis, C A ^a   Townsend, P A ^a   Isacke, C M ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Adhesion; Extracellular matrix; Glycosaminoglycan; Receptor

Indexed keywords

ADHESION; CYTOLOGY; DISEASES; PATHOLOGY; SURFACES;

PHOSPHORYLATION;

BIOCHEMISTRY;

CELL SURFACE RECEPTOR; HERMES ANTIGEN; HYALURONIC ACID; MONOCLONAL ANTIBODY; PROTEIN KINASE (CALCIUM,CALMODULIN); SERINE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME MECHANISM; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD44; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL MOVEMENT; CELLS, CULTURED; HUMANS; HYALURONIC ACID; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RATS; SERINE; SUBSTRATE SPECIFICITY;

EID: 0035425455     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570843     Document Type: Article

References (34)

1. CD44 and its interaction with extracellular matrix
2. The importance of cellular environment to function of the CD44 matrix receptor
3. CD44: Structure, function and association with the malignant process
4. Requirements for hyaluronic acid binding by CD44: A role for the cytoplasmic domain and activation by antibody
5. CD44H regulates tumor cell migration on hyaluronate-coated substrate
6. The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent insoluble cytoskeleton of fibroblasts
7. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function
8. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
9. Hyaluronan binding by CD44 is regulated by a phosphorylation independent mechanism
10. The role of the cytoplasmic domain in regulating CD44 function
11. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44
12. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43 and ICAM-2
13. A di-hydrophobic Leu-Val motif regulates the basolateral localization of CD44 in polarized Madin-Darby canine kidney epithelial cells
14. Identification and characterization of the human Pgp-1 glycoprotein
15. Characterization of a class III collagen receptor, a phosphorylated transmembrane glycoprotein expressed in nucleated human cells
16. Variations in the cytoskeletal interaction and post-translational modification of the CD44 homing receptor in macrophage
17. Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells
18. Defective phosphorylation and hyaluronan binding of CD44 with point mutations in the cytoplasmic domain
19. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325
20. CD44 phosphorylation regulates melanoma and fibroblast migration on, but not attachment to, a hyaluronan substratum
21. Protein kinase recognition sequence motifs
22. Mutational analysis of the autoinhibitory domain of calmodulin kinase II
23. 2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3-hydroxyl5-methyl-4-isoxazole-propionate-type glutamate receptor
24. Getting hydrophilic compounds into cells: Lessons from homeopeptides
25. 2+-calmodulin-dependent protein kinases IV and II reveals shared and distinctive features
26. Protein kinases. Regulation by autoinhibitory domains
27. The multifunctional calcium/calmodulin-dependent protein kinase: From form to function
28. 2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation
29. 2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation
30. Calcium/calmodulin-dependent protein kinase II controls α5β1 integrin-mediated inside-out signaling
31. Substrate specificity of a multifunctional calmodulin-dependent protein kinase
32. CD44 triggering enhances human NK cell cytotoxic functions
33. Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
34. Calmodulin trapping by calcium-calmodulin-dependent protein kinase