Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice

Basic Research in Cardiology

Volumn 95, Issue 6, 2000, Pages 479-484

  Guo, Y ^a   Bao, W ^a   Wu, W J ^a   Shinmura, K ^a   Tang, X L ^a   Bolli, R ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

COX 2; Ischemic preconditioning; Mice; Myocardial infarction

Indexed keywords

CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE;

ANIMAL DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART PROTECTION; MALE; MOUSE; NONHUMAN;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HEART; ISCHEMIC PRECONDITIONING; ISOENZYMES; MICE; MICE, INBRED STRAINS; MYOCARDIAL INFARCTION; MYOCARDIUM; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SULFONAMIDES;

EID: 0034530260     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950070024     Document Type: Article

References (7)

1. The nitric oxide hypothesis of late preconditioning
2. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase: Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning
3. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
4. Demonstration of an early and a late phase of ischemic preconditioning in mice
5. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
6. Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits
7. Cyclooxygenases 1 and 2