Integrated effects of multiple modulators on human liver glycogen phosphorylase a

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 1 46-1, 2002, Pages

  Ercan Fang, Nacide ^a,b   Gannon, Mary C ^a,b,c   Rath, Virginia L ^d   Treadway, Judith L ^d   Taylor, Miriam R ^a   Nuttall, Frank Q ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Department of Medicine ^*  (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Adenosine 5 diphosphate; Adenosine 5 monophosphate; Adenosine 5 triphosphate; Enzyme regulation; Fructose 1 phosphate; Glucose; Glucose 1 phosphate; Glycogen metabolism; Uridine 5 diphosphate glucose

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; FRUCTOSE 1 PHOSPHATE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; URIDINE DIPHOSPHATE GLUCOSE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REGULATION; GLYCOGEN METABOLISM; GLYCOGENOLYSIS; HUMAN; HUMAN TISSUE; MICHAELIS CONSTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0036293652     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00425.2001     Document Type: Article

References (69)

1. Fructose induced depletion of liver adenine nucleotides in man
2. Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat
3. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
4. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
5. 31P magnetic resonance spectroscopy
6. Specific features of glycogen metabolism in the liver
7. Free ADP levels in transgenic mouse liver expressing creatinine kinase. Effects of enzyme activity, phosphagen type, and substrate concentration
8. 31P MRS in vivo. Part 2: Muscle, liver, kidney
9. The inactivation of glycogen phosphorylase in rat is not a prerequisite for the activation of liver glycogen synthase
10. 2+
11. Determination of Krebs cycle metabolic carbon exchange in-vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man
12. 31P-NMR spectroscopy
13. Allosteric regulation of liver phosphorylase a: Revisited under approximated physiological conditions
14. Liver glycogen synthase, phosphorylase and glycogen concentration in rats given a single glucose load orally. A 24 hour study
15. The effect of caffeine and caffeine analogs on rat liver phosphorylase a activity
16. Uric acid inhibits liver phosphorylase a activity under simulated in vivo conditions
17. Conversion of phosphorylase b to phosphorylase a in muscle extracts
18. The structures and related functions of phosphorylase a
19. Changes in liver glycogen synthase activity, protein mass, and synthase mRNA with feeding, fasting and diabetes
20. Effect of twenty-four hours of starvation on plasma glucose and insulin concentrations in people with untreated non-insulin-dependent diabetes mellitus
21. Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: A quantitative study
22. Radiochemical methods for the assay of phosphorylase in the direction of glycogenolysis
23. A radioactive method for the assay of glycogen phosphorylases
24. Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM
25. Control of rat liver glycogen synthetase and phosphorylase activities by glucose
26. Crystalline muscle phosphorylase. I. Preparations, properties and molecular weight
27. Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study
28. Control of hepatic glycogenolysis
29. Evolution of allosteric control in glycogen phosphorylase
30. Adenine nucleotide content of human liver
31. i
32. Differences between metabolic responses to fasting in obese diabetic and obese non-diabetic subjects
33. Glycogen phosphorylase: Control by phosphorylation and allosteric effectors
34. Synergistic regulation of phosphorylase a by glucose and caffeine
35. Regulation of glycogen phosphorylase activity in isolated human hepatocytes
36. NMR detection of creatinine kinase expressed in liver of transgenic mice: Determination of free ADP levels
37. In-vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin
38. Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients
39. Human liver glycogen phosphorylase. Kinetic properties and assay in biopsy specimens
40. Kinetics of purified liver phosphorylase
41. Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy
42. Non-invasive quantitation of human liver metabolites using image-guided 31P magnetic resonance spectroscopy
43. The family of glycogen phosphorylases: Structure and function
44. Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage
45. Mechanism of delayed hepatic glycogen synthesis after an oral galactose load vs. an oral glucose load in adult rats
46. Metabolic effects of oral glucose in the liver of fasted rats
47. Metabolic effects of oral fructose in the liver of fasted rats
48. Effects of graded intravenous doses of fructose on glycogen synthase in the liver of fasted rats
49. The relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats following a glucose load
50. Regulation of glycogen synthesis in the liver
51. Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition
52. A new allosteric site in glycogen phosphorylase b as a target for drug interactions
53. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period
54. Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
55. Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core
56. Age-related changes in hepatic glycogen metabolism in the genetically diabetic (db/db) mouse
57. Hepatic glycogen metabolism in the db/db mouse
58. 13C NMR
59. The nucleotide sequence of rat liver glycogen phosphorylase cDNA
60. The stimulation of liver phosphorylase b by AMP fluoride and sulfate: A technical note on the specific determination of the a and b forms of liver glycogen phosphorylase
61. Lipid-dependent control of hepatic glycogen stores in healthy humans
62. Characteristics of the dephosphorylated form of phosphorylase purified from rat liver and measurement of its activity in crude liver preparation
63. 13C] glucose study
64. Liver glycogen metabolism: An overview
65. Metabolic effects of fructose in the liver
66. Adenylsuccinase deficiency
67. Overexpression of glutamine: Fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
68. Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus
69. Comparative characterization of human and rat liver glycogen synthase