DNA damage and the effect of antioxidants in streptozotocin-treated mice

Food and Chemical Toxicology

Volumn 40, Issue 7, 2002, Pages 979-987

  Imaeda, A ^a   Kaneko, T ^b   Aoki, T ^a   Kondo, Y ^a   Nagase, H ^c  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

8 Hydroxy 2 deoxyguanosine; Antioxidant; Oxidative DNA damage; Reactive oxygen species; Single cell gel electrophoresis assay; Streptozotocin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; DEOXYGUANOSINE; GLUCOSE; PROBUCOL; STREPTOZOCIN; TROLOX C;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROTECTION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; GENOTOXICITY; GLUCOSE BLOOD LEVEL; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; DEOXYGUANOSINE; DNA DAMAGE; KIDNEY; LIVER; MICE; STREPTOZOCIN;

EID: 0036285710     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00014-5     Document Type: Article

References (26)

1. Dietary carcinogens and anticarcinogens
2. Induction of renal tumours by streptozotocin in rats
3. Action of Streptozotocin, an antileucemic antibiotic, on L1210 cells
4. Dose-response curves for liver DNA fragmentation induced in rats by sixteen N-nitroso compounds as measured by viscometric and alkaline elution analyses
5. The comet assay: A comprehensive review
6. The structure of streptozotocin
7. Probucol scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited formation of tiobarbituric acid reactive substances
8. Effectes of antioxidants on the mutagenicity of reactive oxygen species-generating systems towards Salmonella typhimurium TA102 and TA104 strains
9. Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis
10. The use of the single cell electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro
11. Formation of 8-oxo-2′-deoxyguanosine in the DNA of human diploid fibroblasts by treatment with linoleic acid hydroperoxide and ferric ion
12. Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage during aging
13. Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance
14. The effects of N-methyl-N′-nitro-N-nitrosoguanidine and streptozotocin on mammalian cell cultures
15. Mutagenic activity of streptozotocin
16. Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vitro alkaline elution and BrdUrd labeling assays
17. Evalution of a tissue homogenization technique that isolates nuclei for the in vivo single cell gel electrophoresis (comet) assay: A collaborative study by five laboratories
18. Detection of DNA damage induced in vivo following exposure of rats to carcinogens
19. Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay
20. Tissue-specific induction of mutations by streptozotocin in vivo
21. Assay for 8-hydroxy-2′-deoxyguanosine, a biomarker of in vivo oxidative DNA damage
22. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
23. Cytotoxicity and induction of sister chromatid exchanges in human and rodent brain tumor cells treated with alkylating chemotherapeutic agents
24. Measurement of unscheduled DNA synthesis in rat kidney following in vivo treatment with genotoxic agents
25. Free radical intermediates during peroxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methlphenol, and related phenol compounds
26. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer