Cytotoxicity and Induction of Sister Chromatid Exchanges in Human and Rodent Brain Tumor Cells Treated with Alkylating Chemotherapeutic Agents

Cancer Research

Volumn 48, Issue 11, 1988, Pages 3100-3105

  Tokuda, Kouichi ^a   Bodell, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARMUSTINE; ETHYLNITROSOUREA; METHYLNITROSOUREA; NIMUSTINE; STREPTOZOCIN;

ANIMAL CELL; BRAIN TUMOR; CELL CULTURE; CYTOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; SISTER CHROMATID EXCHANGE; TUMOR CELL LINE;

ALKYLATING AGENTS; ANIMAL; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL LINE; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOBLASTOMA; GLIOMA; HUMAN; RATS; SISTER CHROMATID EXCHANGE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0023900145     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bodell, W. J., Rupnialc, H. T. R., Rasmussen, J., Morgan, W. F., and Rosenblum, M. L. Reduced level of DNA crosslinks and sister chromatid exchanges in l, 3-bis(2-chloroethyl)-l-nitrosourea resistant rat brain tumor cells. Cancer Res., 44:3763-3767, 1984.
2. Bodell, W. J., Gerosa, M., Aida, T., and Rosenblum, M. L. Investigation of resistance to DNA crosslinking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas. Cancer Res., 45:3460-3464, 1985.
3. Bodell, W. J., Aida, T., Berger, M. S., and Rosenblum, M. L. Increased repair of Ob-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1, 3-bis(2-chloroethyl)-1 - nitrosourea. Carcinogenesis (Lond.), 7; 879-883, 1986.
4. Aida, T., and Bodell, W. J. Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(H) in human glial derived cell lines. Cancer Res., 47:1361-1366, 1987.
5. Bodell, W. J., Morgan, W. F., Rasmussen, J., Williams, M. E., and Deen, D. F. Potentiation of l, 3-bis(2-ch]oroethyl)-l-nitrosourea (BCNU)-induced cytotoxicity in 9L cells by pretreatment with 6-thioguanine. Biochem. Pharmacol., 34:515-520, 1985.
6. Aida, T., Cheitlin, R. C., and Bodell, W. J. Inhibition of Ob-alkylguanine-DNA-alkyltransferase potentiates cytotoxicity and induction of SCEs in human glioma cells resistant to 1, 3-bis(2-chloroethyl)-1 -nitrosourea. Carcinogenesis (Lond.), 8:1219-1223, 1987.
7. Evans, C. G., Bodell, W. J., Tokuda, K., Doane-Setzer, P., and Smith, M. T. Glutathione and related enzymes in rat brain tumor cell resistance to 1, 3-bis(2-chloroethyl>-1 -nitrosourea and nitrogen mustard. Cancer Res., 47: 2525-2530, 1987.
8. Erickson, L. C., Laurent, G., Sharkey, N. A., and Kohn, K. W. DNA crosslinking and monoadduct repair in nitrosourea-treated human tumor cells. Nature (Lond.), 288:727-729, 1980.
9. Scudiero, D. A., Meyers, S. A., Clatterbuck, B. E., Mattera, M. R., Ziol-kowslti, C. H. F., and Day, R. S. Sensitivity of human cell strains having different abilities to repair Ob-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas. Cancer Res., 44:2467-2474, 1984.
10. Brent, T. P., Houghton, P. J., and Houghton, J. A. Ob-Alkylguanine-DNA-alkyltransferase activity correlates with therapeutic response of human rhabdomyosarcoma xenografts to l-(2-chloroethyl)-3-(trans -4-methylcyclohexyl)-1-nitrosourea. Proc. Natl. Acad. Sci. USA, 82:2985-2989, 1985.
11. Zlotogorski, C., and Erickson, L. C. Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylni-trosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone. Carcinogenesis (Lond.), 4: 759–763, 1983.
12. Zlotogorski, C.,and Erickson, L. C. Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts. Carcinogenesis (Lond.), 5:83-87, 1984.
13. Dolan, M. E., Corsico, C. D., and Pegg, A. E. Exposure of HeLa cells to Ob-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochem. Biophys. Res. Commun., 132:178-185, 1985.
14. Yarosh, D. B., Hurst-Calderone, S., Babich, M. A., and Day, R. S. Inactivation of Ob-methylgumiine-DNA-methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by Ob-methylguanine as a free base. Cancer Res., 46:1663-1668, 1986.
15. Day, R. S., Ziolkowsld, C. H. J., Scudiero, D. A., Meyer, S. A., Lubiniecki, A. S., Girardi, A. J., Galloway, S. M., and Bynum, G. D. Defective repair of alkylated DNA by human tumor and SV-40 transformed human cell strains. Nature (Lond.), 288:724-727, 1980.
16. Gibson, N. W., Hartley, J., LaFrance, R. J., and Vaughan, K. Differential cytotoxicity and DNA damaging effects produced in human cells of the Mere and Mer phenotypes by a series of alkyltriazenylimidazoles. Carcinogenesis 7:259-265, 1986.
17. Gibson, N. W., Hartley, J., LaFrance, R. J., and Vaughan, K. Differential cytotoxicity and DNA damaging effects produced in human cells of the Mer+ and Mer” phenotypes by a series of 1 -aryl-3-alkyltriazenes. Cancer Res., 46: 4999-5003, 1986.
18. Ding, R., Ghosh, K., Eastman, A., and Bresnick, E. DNA mediated transfer and expression of a human DNA repair gene that demethylates Ob-methyl-guanine. Mol. Cell Biol., 5:3293-3296, 1985.
19. Roberts, J. J., Pascoe, J. M., Plant, J. E., Sturrock, J. E., and Crathom, A. R. Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. I. The effect of HeLa and Chinese hamster cell survival of alkylation of cellular macromolecules. Chem.-Biol. Interact, 3:29-47, 1971.
20. Wild, C. P., Smart, G., Saffhill, R., and Boyle, J. M. Radioimmunoassay of Ob-methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo. Carcinogenesis (Lond.), 4:1605-1609, 1983.
21. Foote, R. S., Pal, B. C., and Mitra, S. Quantitation of Ob-methylguanine-DNA-methyl transferase in HeLa cells. Mutat Res., 119:221-228, 1983.
22. Barker, M., Hoshino, T., Guicay, o,Wilson, C. B., Mielsen, S. L., Downie, R., and Eliason, J. Development of an animal brain tumor model and its response to therapy with 1, 3-bis(2-chloroethyl)-01 -nitrosourea. Cancer Res., 33:976-986, 1973.
23. Perry, P., and Wolff, S. New Giemsa method for the differential staining of sister chromatids. Nature (Lond.), 251:156-158, 1974.
24. Ludlum, D. B., Mehta, J. R., and Tong, W. P. Prevention of l-(3-deoxycy-tidy 1), 2-1(1 -deoxyguanosinyl)ethane crosslink formation in DNA by rat liver Ob-alkylguanine-DNA alkyltransferase. Cancer Res., 46:3353-3357, 1986.
25. Brent, T. P. Suppression of crosslink formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts. Cancer Res., 44:1887-1892, 1984.
26. Bodell, W. J., Tokuda, K., and Ludlum, D. B. Quantitation of DNA alkylation products formed in sensitive and resistant glioma cells treated with 1-(2-chloroethyl)-l-nitrosourea. Proc. Amer. Cancer Res., 28:285, 1987.
27. Foote, R. S., and Mitra, S. Lack of induction of 0-methylguanine-DNA methyl transferase in mammalian cells treated with JV-methyWV'-nitro-jV-nitrosoguanidine. Cardinogenesis (Lond.), 5:277-281, 1984.
28. Seidenfeld, J., Barnes, D., Block, A. L., and Erickson, L. C. Comparison of DNA interstrand cross-linking and strand breakage by 1, 3 bis(2-chloroethyl)-1-nitrosourea in polyamine-depleted and control human adenocarcinoma cells. Cancer Res., 47:4538-4543, 1987.
29. Ducore, J. M., and Rosenstein, B. S. Theophylline release of replicon inhibition by nitrosoureas correlated with synergistic cell killing in L1210 leukemia in vitro. Mutat. Res., 146:1-8, 1985.
30. Yoshida, T., Shimizu, K., Ushio, Y., Hayakawa, T., Morgami, H., and Sakamoto, Y. Enhanced effects of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma. Br. J. Cancer, 53:773-777, 1986.
31. Brennard, J., and Margison, G. P. Expression in mammalian cells of a truncated Escherichia coli gene coding for O-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents. Cardinogenesis (Lond.), 7; 2081-2084, 1986.
32. Samson, L., Derfler, B., and Waldstein, E. A. Suppression of human DNA alkylation repair defects by Escherichia coli DNA repair genes. Proc. Natl. Acad. Sci. USA, 83:5607-5610, 1986.
33. Yarosh, D. B., Barnes, D., and Erickson, L. C. Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (Mer+) to a sensitive tumor cell line (Mer-) results in a tumor cell line resistant to MNNG and CNU that has increased Ob-methylguanine-DNA-methyltransferase levels and reduced levels of DNA interstrand crosslinking. Carcinogenesis (Lond.), 7; 1603–1606, 1986.
34. Hayward, I. P., and Parsons, P. G. Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous human melanoma cells resistant to methylating agents. Cancer Res., 44:55-58, 1984.
35. Domoradzki, J., Pegg, A. E., Dolon, M. E., Maher, V. M., and McCormick, J. J. Correlation between Ob-methyl guanine-DNA-methyl transferase activity and resistance of cells to the cytotoxic and mutagenic effects of N-methyl-N-nitro-N-nitrosoguanidine. Carcinogenesis (Lond.), 5:1641-1647, 1984.
36. Goldmacher, V. S., Cuzick, R. A., and Thilly, W. G. Isolation and characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-Ar-nitro-N-nitrosoguanidine. J. Biol. Chem., 261:12462-12471, 1986.
37. Samson, L., and Linn, S. DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells. Carcinogenesis (Lond.), 8:227-230, 1987.
38. Goth-Goldstein, R. MNNG-induced partial phenotypic reversion of Mer“ cells. Carcinogenesis (Lond.), 8:1449-1453, 1987.
39. Ishida, R., and Takahashi, T. N-methyl-N'-nitrosoguanidine-resistant Hela S3 cells still have little Ob-methylguanine-DNA methyltransferase activity and are hypermutable by alkylating agents. Carcinogenesis (Lond.), 8:1109-1113, 1987.
40. Wolff, S. M., Rodin, B., and Cleaver, J. E. Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells. Nature (Lond.), 265:347-349, 1977.
41. Thomson, V. E., and Evans, H. J. Induction of sister chromatid exchanges in human lymphocytes and Chinese hamster cells exposed to aflatoxin Bt, and N-methyl-N-nitrosourea. Mutat Res., 67:47-53, 1979.
42. Morris, S. M., Heflich, R. H., Beranek, D. T., and Kodell, R. L. Alkylation induced sister chromatid exchanges correlate with reduced cell survival not mutations. Mutat Res., 105:163-168, 1982.
43. Connell, J. R., and Medcalf, A. S. C. The induction of SCE and chromosomal aberrations with relation to specific base methylation of DNA in Chinese hamster cells by N-methy-N-nitrosourea and dimethyl sulfate. Carcinogenesis, (Lond.), 3:385-390, 1982.
44. Natarajan, A. T., Simons, J. W. I. M., Vogel, E. W., and Van Zeeland, A. A. Relationship between cell killing, chromosomal aberrations, sister chromatid exchanges and point mutations by monofunctional alkylating agents in Chinese hamster cells. Mutat Res., 128:31-40, 1984.
45. White, G. R. M., Ochey, C. H., Brennand, J., and Margison, G. P. Chinese hamster cells harbouring the Escherichia coli Ob-alkylguaninealkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents. Carcinogenesis (Lond.), 7: 2077-2080.1986.
46. Scudiero, D. A., Meyer, S. A., Clatterbuck, B. E., Mattern, M. R., Ziolkowski, C. F. J., and Day, R. S. Relationship of DNA repair phenotypes of human fibroblast and tumor strains to killing by N-methyl-N'-nitro-Ataitrosoguan-idine. Cancer Res., 44:961-969, 1984.
47. Reynolds, R. J., Natanyan, A. T., and Lohman, P. H. M) Micrococcus luteus UV-endonuclease sensitive sites and sister chromatid exchanges in Chinese hamster ovary cells. Mutat Res., 64:353-356, 1979.
48. Heflich, R. H., Morris, S. M., Beranek, D. T., McGarrity, L. J., Chen, J. J., and Beland, F. A. Relationship between the DNa adducts and the mutations and sister chromatid exchanges produced in Chinese hamster ovary cells by jV-hydroxy-2-aminofluorene, V-hydroxy-V'-acetylbenzidine and 1-nitroso-pyiene. Mutagenesis /;201-206, 1986.
49. Ishizaki, K., Tsujimura, T., Yawata, H., Fujio, C., Nakabeppu, Y., Selciguchi M., and Ikenaga, M. Transfer of the E. coli Ob-methylguaninemethyltrans-ferase gene into repair-deficient human cells and restoration of cellular resistance of N-methyl-N'-nitro-N-nitrosoguanidine. Mutat Res., 166:135-141.1986.