Raloxifene treatment increases plasma levels of β-endorphin in postmenopausal women: A randomized, placebo-controlled study

Fertility and Sterility

Volumn 77, Issue 6, 2002, Pages 1110-1117

  Neele, Simone J M ^a   Evertz, Reinder ^a   Genazzani, Andrea R ^b   Luisi, Michele ^b   Netelenbos, Coen ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Endorphins; Climacteric symptoms; HRT; Menopause; SERM

Indexed keywords

BETA ENDORPHIN; PLACEBO; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ADRENERGIC SYSTEM; ADULT; AGED; ARTICLE; CLIMACTERIUM; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SELECTIVITY; FEMALE; HORMONE SUBSTITUTION; HUMAN; OUTPATIENT DEPARTMENT; PILOT STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TIME;

AGED; BETA-ENDORPHIN; CLIMACTERIC; FEMALE; HUMANS; MIDDLE AGED; PILOT PROJECTS; PLACEBOS; POSTMENOPAUSE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATORS; VASOMOTOR SYSTEM;

EID: 0036282719     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(02)03108-4     Document Type: Article

References (47)

1. Current perspectives on the benefits of HRT in menopausal women
2. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
3. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease
4. Estrogen replacement therapy and risk of Alzheimer disease
5. Neuroprotection by estradiol
6. Endogenous opioid peptides and the control of the menstrual cycle
7. Neural signals that regulate GnRH neurones directly during the oestrous cycle
8. Menopause and the central nervous system: Intervention options
9. Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women
10. Hormone replacement therapy: Effects of neurotransmitters, neuropeptides, neurosteroids and the quality of life
11. Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain
12. Physiology of beta-endorphins. A close-up view and a review of the literature
13. Peptide transport systems for opiates across the blood-brain barrier
14. Transport of CRH from mouse brain directly affects peripheral production of beta-endorphin by the spleen
15. Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides
16. Menopausal syndrome: Plasma levels of beta-endorphin in post-menopausal women measured by a specific radioimmunoassay
17. Beta-lipotropin and beta-endorphin in physiological and surgical menopause
18. Increase of proopiomelanocortin-related peptides during subjective menopausal flushes
19. Menopause, depression, and plasma opioids
20. A meta-analysis of the effect of hormone replacement therapy upon depressed mood
21. Raloxifene hydrochloride, a selective estrogen receptor modulator: Safety assessment of effects on cognitive function and mood in postmenopausal women
22. Raloxifene affects brain activation patterns in postmenopausal women during visual encoding
23. Adverse events reported by postmenopausal women in controlled trials with raloxifene
24. Characterization of hot flashes reported by healthy postmenopausal women receiving raloxifene or placebo during osteoporosis prevention trials
25. Impact of climacteric on well-being. A survey based on 5213 women 39 to 60 years old
26. Effects of estrogen-progestin replacement therapy on plasma beta-endorphin levels in menopausal women
27. Steroid replacement treatment increases beta-endorphin and beta-lipotropin plasma levels in postmenopausal women
28. Effect of cold stress on the concentrations in the hypothalamus, pituitary, and blood of beta-lipotropin and beta-endorphin in the rabbit]
29. Raloxifene analog LY 117018 effects on central and peripheral beta-endorphin
30. Beta-Endorphin in human cerebrospinal fluid
31. Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol
32. Short-term effects of ovariectomy: The opioid control of LH secretion in fertile climacteric and postmenopausal women
33. Menopausal hot flushes, plasma calcitonin and beta-endorphin. A preliminary report
34. Estrogens as neuromodulators
35. Clinical efficacy of raloxifene in postmenopausal women
36. Raloxifene
37. The opiomelanotropinergic neuronal and endocrine systems
38. Evidences for a dopamine-regulated peripheral source of circulating beta-endorphin
39. Raloxifene and estrogen effects on quality of life in healthy postmenopausal women: A placebo-controlled randomized trial
40. Clinical review 108: The molecular and neuroanatomical basis for estrogen effects in the central nervous system
41. Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: Distinct distribution pattern to ERalpha mRNA
42. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
43. Estrogen receptor beta: Re-evaluation of estrogen and antiestrogen signaling
44. Neuroendocrinological function in Alzheimer's disease
45. Aging brain and dementias: Changes in central opioids
46. CSF beta-endorphin and beta-lipotropin in Alzheimer's disease and multi-infarct dementia
47. Neuromodulatory role of opioidergic system on hypothalamus-pituitary-gonadal axis during puberty