Conservation of RET proto-oncogene splicing variants and implications for RET isoform function

Cytogenetics and Cell Genetics

Volumn 95, Issue 3-4, 2002, Pages 169-176

  Carter, M T ^a   Yome, J L ^a   Marcil, M N ^a   Martin, C A ^a   Vanhorne, J B ^a   Mulligan, L M ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PROTEIN RET; PROTEIN RET43; PROTEIN RET51; PROTEIN RET9; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; GENE FUNCTION; GENE LOCUS; GENETIC VARIABILITY; MOLECULE; MOUSE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTO ONCOGENE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; DROSOPHILA PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

VERTEBRATA;

EID: 0036278945     PISSN: 03010171     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Grb2 binding to the different isoforms of Ret tyrosine kinase
2. Identification of Shc docking site on Ret tyrosine kinase
3. Expression of the RET proto-oncogene in human embryos
4. Developmental expression of the RET protooncogene
5. Expression of c-ret in the zebrafish embryo: Potential roles in motoneural development
6. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase C gamma
7. The oncogenic versions of the ret and trk tyrosine kinases bind Shc and Grb2 adaptor proteins
8. Induction of RET proto-oncogene expression in neuroblastoma cells preceded neuronal differentiation and is not mediated by protein synthesis
9. Signaling through Ras is essential for Ret oncogene-induced cell differentiation in PC12 cells
10. Expression of the RET oncogene induces differentiation of SK-N-BE neuroblastoma cells
11. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
12. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival
13. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2
14. Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain
15. Mutations of the RET proto-oncogene in Hirschsprung's disease
16. Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours
17. Multiple endocrine neoplasia type 2 and RET: From neoplasia to neurogenesis
18. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
19. The Drosophila Ret gene is transcribed in multiple alternatively spliced forms
20. The role of amino acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain
21. The expression of RET and its multiple splice forms in developing human kidney
22. Expression of RET 3′ splicing variants during human kidney development
23. cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily
24. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction
25. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
26. RET alternative splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc and the SH2 domain of Grb2
27. The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis
28. cDNA sequence and genomic structure of the rat RET proto-oncogene. DNA
29. The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: Evidence for a competition between Shc and IRS-1 for the binding to Ret
30. Docking protein frs2 links the protein tyrosine kinase ret and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
31. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
32. Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C terminus for RET
33. Expression of the c-ret proto-oncogene during mouse embryogenesis
34. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10
35. Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages
36. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
37. Distinct biological properties of two RET isoforms activated by MEN 2A/FMTC and MEN 2B mutations
38. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
39. -mutant mice result from defects in ureteric bud development
40. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
41. Polymorphism identification within 50 equine gene-specific sequence tagged sites
42. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
43. Catalytic specificity of protein-tyrosine kinases is critical for selective signaling
44. A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
45. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line
46. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites
47. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase