T-cell immune constitution after peripheral blood mononuclear cell transplantation in complete DiGeorge syndrome

British Journal of Haematology

Volumn 117, Issue 4, 2002, Pages 899-906

  Bensoussan, Danièle ^a,b,f   Le Deist, Françoise ^c   Latger Cannard, Véronique ^a,b   Grégoire, Marie José ^a   Avinens, Odile ^d   Feugier, Pierre ^a   Bourdon, Violaine ^a   André Botté, Christine ^a   Schmitt, Claudine ^e   Jonveaux, Philippe ^a   Eliaou, Jean François ^d   Stoltz, Jean François ^a,b   Bordigoni, Pierre ^e  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b CNRS   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d MONTPELLIER UNIVERSITY HOSPITAL   (France)

^e HÔPITAL D ENFANTS   (France)

^f Chu de Nancy   (France)

Author keywords

Chimaerism; Complete DiGeorge syndrome; Immune constitution; Peripheral expansion; Transplantation

Indexed keywords

ANTIGEN; CYCLOSPORIN A; MITOGENIC AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADOPTIVE IMMUNOTHERAPY; ANTIBODY PRODUCTION; ARTICLE; BLOOD DONOR; CASE REPORT; CELL POPULATION; CHIMERA; CONTROLLED STUDY; DIGEORGE SYNDROME; DISEASE SEVERITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNIZATION; LYMPHOCYTE COUNT; MALE; MEMORY CELL; MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; RECURRENT INFECTION; SIBLING; T LYMPHOCYTE; TREATMENT OUTCOME;

ACUTE DISEASE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIGEORGE SYNDROME; GRAFT VS HOST DISEASE; HUMANS; IMMUNIZATION; INFANT, NEWBORN; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COUNT; MALE; POLYMORPHISM, GENETIC; POSTOPERATIVE PERIOD; T-LYMPHOCYTES; TRANSPLANTATION CHIMERA; TRANSPLANTATION, ISOGENEIC;

EID: 0036277691     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03496.x     Document Type: Article

References (41)

1. Severe eczema in a patient with DiGeorge's syndrome
2. Establishment of immunological competence in a child with congenital thymic aplasia by a graft of fetal thymus
3. A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis
4. Clinical and immunologic spectrum of the DiGeorge syndrome
5. Prediction of persistent immunodeficiency in the DiGeorge anomaly
6. Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS)
7. Successful bone marrow transplantation with split lymphoïd chimerism in DiGeorge Syndrome
8. Immune constitution of complete DiGeorge anomaly by transplantation of unmobilized blood mononuclear cells
9. Rapid regeneration of normally functional naive CD4+ T cells after bone marrow transplantation from unrelated donors for combined immunodeficiency
10. Immune reconstitution after bone marrow transplantation for combined immunodeficiencies. Down-modulation of Bcl-2 and high expression of CD95-Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death
11. Fœtal thymic transplant in a case of DiGeorge's syndrome
12. Possible extrathymic development of nonfunctional T cells in a patient with Complete DiGeorge Syndrome
13. A common region of 10p deleted in DiGeorge and velocardiofacial syndromes
14. Changes in thymic function with age and during the treatment of HIV infection
15. Assessment of thymic output in adults after haematopoietic stem cell transplantation and prediction of T-cell reconstitution
16. Fidelity of the repertoire in T cell reconstituted athymic nude rats. Preservation of a deficit in alloresponsiveness over one year
17. Prevalence of 22q11 micro deletion in DiGeorge and velocardiofacial syndromes: Implications for genetic counseling in prenatal diagnosis
18. Population Biology of lymphocytes: The flight for survival
19. Alterations of T cell repertoire after bone marrow transplantation: Characterization of over-represented subsets
20. Bone marrow transplantation in DiGeorge syndrome
21. Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
22. Graft vs graft reaction resulting in the elimination of the maternal cells in a SCID patient with maternofetal GVHD after an HLA identical bone marrow transplantation
23. T-cell regeneration: All repertoires are not created equal
24. Transplantation of thymus tissue in complete DiGeorge syndrome
25. Complete-type DiGeorge syndrome treated by bone marrow transplantation
26. DiGeorge syndrome with hypogammaglobulinemia: A patient with excess suppressor T cell activity treated with fetal thymus transplantation
27. Donor immunization with Haemophilus influenzae type b (HIB) -conjugate vaccine in allogeneic bone marrow transplantation
28. The DiGeorge sequence: Immunologic findings in partial and complete forms of the disorder
29. Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
30. Human equivalent of the mouse Nude/SCID phenotype: Long term evaluation of immunologic reconstitution after bone marrow transplantation
31. Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns
32. The extrathymic T-cell development pathway
33. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity
34. Thymus and autoimmunity. Capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease
35. Thyroid abnormalities as a feature of DiGeorge syndrome: A patient report and review of the literature
36. Clonal cytotoxic T-cells are expanded in myeloma and reside in the CD8+CD57+CD28- compartment
37. Peripheral selection of T cell repertoires: The role of continuous thymus output
38. The organization of mature T-cell pools
39. The organization of mature T cell pools. Philosophical transactions of the Royal Society of London. Series B
40. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects
41. Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host-disease among lethally irradiated dogs given DLA-non identical unrelated marrow grafts