Optic nerve degeneration and potential neuroprotection: Implications for glaucoma

European Journal of Ophthalmology

Volumn 9, Issue SUPPL. 1, 1999, Pages

  Schwartz, M ^a   Yoles, E ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Alpha 2 adrenoreceptor agonists; Glutamate; Neuroprotection; NMDA receptor antagonists; Optic nerve degeneration; Partial rat crush injury model

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CRUSH TRAUMA; CYTOTOXICITY; DRUG EFFECT; ELECTROPHYSIOLOGY; GLAUCOMA; MEDIATOR RELEASE; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; OPTIC NERVE DISEASE; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

EID: 0032926544     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067219900901s07     Document Type: Article

References (10)

1. Schwartz M, Yoles E, Belkin M, Solomon A. Potential treatment modalities for glaucomatous neuropathy: Neuroprotection and neuroregeneration. J Glaucoma 1996; 5: 427-32.
2. Yoles E, Schwartz M. Evidence for secondary degeneration of spared neurons following partial white matter lesion: implications for optic nerve neuropathies. Exp Neurol 1998; 53: 1-7.
3. Yoles E, Schwartz M. Elevation of intraocular glutamate in rats with partial lesion of the optic nerve. Arch Ophthalmol 1998; 116: 906-10.
4. Yoles E, Schwartz M. Potential neuroprotective therapy for glaucomatous optic neuropathy. Surv Ophthalmol 1998; 42: 367-72.
5. Duvdevani R, Rosner M, Belkin M, Sautter J, Sabel BA, Schwartz M. Graded crush of the rat optic nerve as a brain injury model: Combining electrophysiological, histological and behavioral outcome. J Restorative Neurol Neurosci 1990; 2: 31-8.
6. Eitan, S, Solomon A, Lavie V, Yoles E, Hirschberg DL, Belkin M, Schwartz M. Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science 1994; 264: 1764-8.
7. Moalem, G, Yoles E, Cohen IR, Schwartz M. Autoimmune T cells limit secondary degeneration following central nervous system trauma. Nature Med (in press).
8. Yoles E, Belkin M, Schwartz M. HU-211, a nonpsychotropic cannabinoid, produces short- and long-term neuroprotection after optic nerve axotomy. J Neurotrauma 1996; 13: 49-57.
9. Yoles E, Muler S, Schwartz M. N-methyl-D-aspartate-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush. J Neurotrauma 1997; 14: 665-75.
10. Yoles E, Wheeler LA, Schwartz M. Alpha-2 adrenoreceptor agonists are neuroprotective in an experimental model of optic nerve degeneration in the rat. Invest Ophthalmol Vis Sci 1999; 40: 65-73.