Anti-La/SSB antibodies transported across the placenta bind apoptotic cells in fetal organs targeted in neonatal lupus

Arthritis and Rheumatism

Volumn 46, Issue 6, 2002, Pages 1572-1579

  Tran, Hai B ^a   Macardle, Peter J ^a   Hiscock, Jenny ^a   Cavill, Dana ^a   Bradley, John ^a   Buyon, Jill P ^b   Gordon, Tom P ^a,c  

^a FLINDERS UNIVERSITY   (Australia)

^b NYU HOSPITAL FOR JOINT DISEASES   (United States)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RO; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN G; LA ANTIBODY; PARAFFIN; RECOMBINANT ANTIGEN; RIBONUCLEOPROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; APOPTOSIS; ARTICLE; BONE; BRAIN; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETUS; FETUS CIRCULATION; FETUS HEART; FETUS LIVER; FROZEN SECTION; HEART ATRIOVENTRICULAR NODE; HISTOLOGY; HUMAN; IN VIVO STUDY; INFLAMMATION; INTESTINE; LUPUS ERYTHEMATOSUS; MOUSE; NICK END LABELING; NONHUMAN; PASSIVE IMMUNIZATION; PLACENTA; PLACENTAL TRANSFER; PRIORITY JOURNAL; SKIN; THYMUS; TISSUE INJURY;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; DISEASE TRANSMISSION, VERTICAL; FEMALE; FETUS; HUMANS; IMMUNOGLOBULIN G; IN SITU NICK-END LABELING; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; PREGNANCY; RIBONUCLEOPROTEINS;

EID: 0036269511     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10316     Document Type: Article

References (27)

1. Autoantibodies directed against sicca syndrome antigens in neonatal lupus
2. Connective tissue disease, antibodies to ribonucleoprotein, and congenital heart block
3. Autoantibodies to SS-A/Ro in infants with congenital heart block
4. Neonatal lupus erythematosus
5. Neonatal lupus syndromes
6. Anatomy of congenital heart block and relation to maternal anti-Ro antibodies
7. Spectrum of cardiac histopathology in cases of autoimmune-associated congenital heart block (CHB) obtained from the Research Registry for Neonatal Lupus
8. Cardiac rhythm and conduction disturbances: What is the role of autoimmune mechanisms?
9. Significance of autoantibodies in neonatal lupus erythematosus
10. Neonatal lupus syndrome: The heart as a target of the immune system
11. Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
12. Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block
13. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
14. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes
15. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages
16. Subcellular redistribution of La/SS-B autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: A clue to the pathogenesis of congenital heart block
17. Preliminary criteria for the classification of Sjögren's syndrome: Results of a prospective concerted action supported by the European Community
18. Neonatal hemochromatosis associated with maternal autoantibodies against Ro/SS-A and La/SS-B ribonucleoproteins
19. Definition of a discontinuous immunodominant epitope at the NH2 terminus of the La/SS-B ribonucleoprotein autoantigen
20. The isolation of IgG from mammalian sera with the aid of caprylic acid
21. Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice
22. The immune response to 52-kilodalton Ro and 60-kilodalton Ro is linked in experimental autoimmunity
23. Structural differences between the human and mouse 52-kDa Ro autoantigens associated with poorly conserved autoantibody activity across species
24. An animal model of antibody binding in cutaneous lupus
25. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice
26. Photosensitivity diseases: Cutaneous lupus erythematosus