Subcellular redistribution of La/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: A clue to the pathogenesis of congenital heart block

Arthritis and Rheumatism

Volumn 46, Issue 1, 2002, Pages 202-208

  Tran, Hai B ^a   Ohlsson, Maria ^b   Beroukas, Dimitra ^a   Hiscock, Jenny ^a   Bradley, John ^a   Buyon, Jill P ^c   Gordon, Tom P ^a,d  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF BERGEN   (Norway)

^c NYU HOSPITAL FOR JOINT DISEASES   (United States)

^d FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; DNA; LA ANTIGEN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RIBONUCLEOPROTEIN; RO ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DISRUPTION; CONFOCAL MICROSCOPY; CONGENITAL HEART BLOCK; CONTROLLED STUDY; FEMALE; FETUS; FETUS HEART; HEART ATRIOVENTRICULAR NODE; NONHUMAN; PRIORITY JOURNAL; RAT; SINUS NODE;

ANIMALS; APOPTOSIS; AUTOANTIGENS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEART BLOCK; HEART CONDUCTION SYSTEM; IMMUNITY, MATERNALLY-ACQUIRED; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED BALB C; MYOCARDIUM; PREGNANCY; RIBONUCLEOPROTEINS;

EID: 0036159163     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200201)46:1<202::AID-ART10062>3.0.CO;2-Y     Document Type: Article

References (18)

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3. Concentration of autoantibodies to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block
4. Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
5. Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block
6. Autoantigens as substrates for apoptotic proteases: Implication for the pathogenesis of systemic autoimmune disease
7. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes
8. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-α by macrophages
9. 2-glycoprotein I antibodies
10. Intracellular localization and nucleocytoplasmic transport of Ro RNP components
11. The La(SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis
12. La autoantigen is cleaved in the COOH terminus and loses the nuclear localization signal during apoptosis
13. Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis
14. Programmed cell death in the developing heart: Regulation by BMP4 and FGF2
15. Apoptosis in cardiac development
16. Normal and abnormal consequences of apoptosis in the human heart
17. Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies
18. Absence of conduction defects in the echocardiograms of mothers with children with congenital complete heart block