Cytotoxic effects of gold(III) complexes on established human tumor cell lines sensitive and resistant to cisplatin

Anti-Cancer Drug Design

Volumn 13, Issue 1, 1998, Pages 67-80

  Calamai, Paola ^a   Carotti, Stefania ^a,b   Guerri, Annalisa ^a   Mazzei, Teresita ^a,b   Messori, Luigi ^a   Mini, Enrico ^a,b   Orioli, Pierluigi ^a   Speroni, Gian Paolo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NONE   (Italy)

Author keywords

Circular dichroism; Cytotoxicity; DNA binding; Gold(III) complex

Indexed keywords

CISPLATIN; DNA; GOLD COMPLEX;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CIRCULAR DICHROISM; CONTROLLED STUDY; CROSS RESISTANCE; DNA CONFORMATION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG RESISTANCE; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; OVARY CARCINOMA; PRIORITY JOURNAL; SPECTROSCOPY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CIRCULAR DICHROISM; DNA; DNA ADDUCTS; DRUG RESISTANCE, NEOPLASM; GOLD; HUMANS; ORGANOMETALLIC COMPOUNDS; SPECTRUM ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0031962945     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BELL, J.D., NORMAN, R.E. &. SADLER, P.J. (1987). Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media. Journal of Inorganic Biochemistry, 31, 241.
2. BLANK, C.E. & DABROWIAK, J.C. (1984). Absorption and circular dichroism studies of a gold(I)-DNA complex. Journal of Inorganic Biochemistry, 21, 21.
3. BLOEMINK, M.J. & REEDIJK, J. (1996). Cisplatin and derived anticancer drugs: mechanism and current status of DNA binding. In Metal Ions in Biological Systems. Sigel, A. & Sigel, H. (eds), p. 641. Marcel Dekker: New York.
4. BRUNI, B., FERRARONI, M., ORIOLI, P. & SPERONI, G.P. (1996). A biological active gold complex: trichloro[(2-pyridil)methanol-N]gold(III). Acta Crystallographica, C52, 1423.
5. 2(pm). Journal of Inorganic Biochemistry, 66, 103.
6. CALIS, G.H.M. & HADJILIADIS, N. (1984). Structure and bonding of gold(I) and gold(III) nucleosides studied by 197Au Mössbauer spectroscopy. Inorganica Chimica Acta, 91, 203.
7. CLARKE, M.J. & STUBBS, M. (1996). Interactions of metallopharmaceuticals with DNA. In Metal Ions in Biological Systems. Sigel, A. & Sigel, H. (eds), p. 727. Marcel Dekker: New York.
8. DAR, A., MOSS, K., COTTRILL, S.M., PARISH, R.V., McAULIFFE, C.A., PRITCHARD, R.G., BEAGLEY, B. & SANDBANK, J. (1992). Complexes of gold(III) with mononegative bidentate N,O-ligands. Journal of the Chemical Society, Dalton Transactions, 1907.
9. GIELEN, M., LELIEVELD, P., De vos, D. & WILLEM, R. (1993). In vitro antitumor activity of organotin(IV) derivatives of salycilic acid and related compounds. In Metal Complexes in Cancer Chemotherapy. Keppler, B.K. (ed.), p. 381. VCH: Weinheim.
10. GRAY, D.M., RATLIFF, R.L. & VAUGHAN, M.R (1992) Circular dichroism spectroscopy of DNA. Methods in Enzymology, 211, 389.
11. HADJILIADIS, N., PNEUMATIKAKIS, G. & BASOSI, R. (1981). Gold complexes of purine and pyrimidine nucleosides. Journal of Inorganic Biochemistry, 14, 115.
12. HOLLER, E. (1993). Mechanism of action of tumor-inhibiting metal complexes. In Metal Complexes in Cancer Chemotherapy. Keppler, B.K. (ed.), p. 37. VCH: Weinheim.
13. KELLAND, L.R. (1994). The molecular basis of cisplatin sensitivity/resistance. European Journal of Cancer, 30A, 725.
14. KEPPLER, B.K. (1993a). Metal Complexes in Cancer Chemotherapy.VCH: Weinheim.
15. KEPPLER, B.K., FRIESEN, C, VONGERIGHTEN, H. & VOGEL, E. (1993b). Budotitane, a new tumor-inhibiying titanium compound: preclinical and clinical development. In Metal Complexes in Cancer Chemotherapy. Keppler, B.K. (ed.), p. 297. VCH: Weinheim.
16. LEVER, A.B.P. (1984). Inorganic Electronic Spectroscopy, Vol. 33. Elsevier: Amsterdam.
17. LU, Y, HAN, J. & SCANLON, K.J. (1988). Biochemical and molecular properties of cisplatin resistant A2780 cells grown in folinic acid. Journal of Biological Chemistry, 263, 4891.
18. MIRABELLI, C.K., SUNG, C.-M., ZIMMERMAN, J.P., HILL, D.T. & MONG, S. CROOKE, S.T. (1986). Interactions of gold coordination complexes with DNA. Biochemical Pharmacology, 35, 1427.
19. NEWMAN, E.M., LU, Y, KASHANI-SABET, M., KESEVAN, V. & SCANLON, K.J. (1988). Mechanism of cross resistance to methotrexate and 5 fluorouracil in an A2780 human ovarian carcinoma cell subline resistant to cisplatin. Biochemical Pharmacology, 37, 443.
20. NI DHUBHGHAILL, O.M. & SADLER, P.J. (1993). Gold complexes in cancer chemotherapy. In Metal Complexes in Cancer Chemotherapy. Keppler, B.K. (ed.), p. 221. VCH: Weinheim.
21. PUDDEPHATT, R.J. (1978). The Chemistry of Gold. Elsevier: Amsterdam.
22. SADLER, PX & SUE, R.E. (1994). The chemistry of gold drugs. Metal-Based Drug, 1, 107.
23. SCANLON, K.J., KASHANI-SABET, M., TONE, T. & FUNATO, T. (1992). Cisplatin resistance in human cancer. Pharmacological Therapy, 53, 385.
24. SKEKAN, P., STRORENG, R., SCUDIERO, D., MONKS, A., McMAHON, J, VISTICA, D., WARREN, J.T., BOKESCH, H., KENNEY, S. & BOYD, M.R. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. Journal of the National Cancer Institute, 82, 1107.
25. WARD, B. & DABROWIAK, J.C. (1987). DNA binding specificity of the gold(III) complex (C2H5)3PAuBr3. Journal of the American Chemical Society, 109, 3810.
26. WHITEHEAD, J. P. & LIPPARD, S. J. (1996). Proteins that bind to and mediate the biological activity of platinum anticancer drug-DNA adducts. In Metal Ions in Biological Systems. Sigel, A. & Sigel, H. (eds), p. 687. Marcel Dekker: New York.