A Caenorhabditis elegans pheromone antagonizes volatile anesthetic action through a go-coupled pathway

Genetics

Volumn 161, Issue 1, 2002, Pages 109-119

  Van Swinderen, Bruno ^a   Metz, Laura B ^a   Shebester, Laynie D ^a   Michael Crowder, C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; PHEROMONE;

ANESTHESIA MECHANISM; ARTICLE; CAENORHABDITIS ELEGANS; DOSE RESPONSE; GENE MUTATION; LOCOMOTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; SENSORY NERVE CELL;

ANESTHETICS, INHALATION; ANIMALS; CAENORHABDITIS ELEGANS; DRUG RESISTANCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HALOTHANE; HETEROTRIMERIC GTP-BINDING PROTEINS; LARVA; NEUROTRANSMITTER AGENTS; PHEROMONES; RECEPTORS, NEUROTRANSMITTER; SIGNAL TRANSDUCTION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; NEMATODA;

EID: 0036266432     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Sensory control of dauer larva formation in Caenorhabditis elegans
2. The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor
3. Contol of larval development by chemosensory neurons in Caenorhabditis elegans
4. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans
5. The genetics of Caenorhabditis elegans
6. The neural circuit for touch sensitivity in Caenorhabditis elegans
7. Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function
8. Behavioral effects of volatile anesthetics in Caenorhabditis elegans
9. G-protein-coupled receptors for peptide hormones in yeast
10. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
11. Molecular and cellular mechanisms of general anaesthesia
12. Which molecular targets are most relevant to general anaesthesia?
13. Molecular genetical analysis of Drosophila ether sensitive mutants
14. A pheromone influences larval development in the nematode Caenorhabditis elegans
15. The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature
16. A gene affecting production of the Caenorhabditis elegans dauer-inducing pheromone
17. Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: The RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity
18. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor
19. Enhancement of gamma-aminobutyric acid-activated Cl-currents in cultured rat hippocampal neurones by three volatile anaesthetics
20. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
21. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue
22. A genetic study of the anesthetic response: Mutants of Drosophila melanogaster altered in sensitivity to halothane
23. Reduction by general anaesthetics of group Ia excitatory postsynaptic potentials and currents in the cat spinal cord
24. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release
25. Pheromone signalling and polarized morphogenesis in yeast
26. Mutations that affect ion channels change the sensitivity of Drosophila melanogaster to volatile anesthetics
27. Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
28. Volatile anesthetics depress glutamate transmission via presynaptic actions
29. Genes required for GABA function in Caenorhabditis elegans
30. Participation of the protein Go in multiple aspects of behavior in C. elegans
31. 2+ transients and glutamate release in isolated cerebral synaptosomes
32. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
33. Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans
34. Halothane presynaptically depresses synaptic transmission in wild-type Drosophila larvae but not in halothane-resistant (har) mutants
35. Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses
36. Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants
37. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites
38. TGF beta-related pathways. Roles in Caenorhabditis elegans development
39. Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents
40. Synaptic transmission
41. One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction
42. Genetic and environmental regulation of dauer larva development
43. Eat-11 encodes GPB-2, a Gbeta(5) ortholog that interacts with G(o)alpha and G(q)alpha to regulate C. elegans behavior
44. Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism
45. Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans
46. Partial constitutive activation of pheromone responses by a palmitoylation-site mutant of a G protein alpha subunit in yeast
47. Mechanisms of halothane action on synaptic transmission in motoneurons of the newborn rat spinal cord in vitro
48. Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans
49. Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila
50. The G-protein β-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)α-G(q)α signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16
51. Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans
52. A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans
53. Goα regulates volatile anesthetic action in Caenorhabditis elegans
54. On biological assays involving quantal responses
55. The structure of the nervous system of Caenorhabditis elegans
56. Depression of spinal monosynaptic transmission by diethyl ether: Quantal analysis of unitary synaptic potentials