Size and quality of randomised controlled trials in head injury: Review of published studies

British Medical Journal

Volumn 320, Issue 7245, 2000, Pages 1308-1311

  Dickinson, Karen ^a   Bunn, Frances ^a   Wentz, Reinhard ^a   Edwards, Phil ^a   Roberts, Ian ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; ANESTHETIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIULCER AGENT; APTIGANEL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CORTICOSTEROID; DIMETHYL SULFOXIDE; DIURETIC AGENT; ELIPRODIL; MACROGOL; METHYLPHENIDATE; PHOSPHOLIPID; PIRACETAM; PRAMIRACETAM; PYRITINOL; SPASMOLYTIC AGENT; STEROID; SUPEROXIDE DISMUTASE; TROMETAMOL; VASOPRESSIN;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DATA BASE; DISABILITY; ERROR; HEAD INJURY; HUMAN; MAJOR CLINICAL STUDY; MEDICAL LITERATURE; MEDICAL RESEARCH; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK;

EID: 0034643618     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.320.7245.1308     Document Type: Article

References (17)

1. 1 Murray CJL, Lopez AD. Global health statistics: a compendium of incidence, prevalence and mortality estimates for over 200 conditions. Boston: Harvard University Press, 1996.
2. 2 World Bank. Global road safety partnership. Washington, DC: World Bank, 1999.
3. 3 Peto R, Collins R, Gray R. Large-scale randomised evidence: large simple trials and overviews of trials. J Clin Epidemiol 1995;48:23-40.
4. 4 Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408-12.
5. 5 Teasdale G. The treatment of head trauma: implications for the future. J Neurotrauma 1991;8(suppl 1):53-60.
6. 6 Royal College of Surgeons of England. Report of the working party on the management of patients with head injury. London: Royal College of Surgeons, 1999.
7. 7 Roberts I, Schierhout G, Alderson P. Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review. J Neurol Neurosurg Psychiatry 1998;65:729-33.
8. 8 CAST (Chinese Acute Stroke Trial) Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997;349:1641-9.
9. 9 ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction. Lancet 1988;ii:349-60.
10. 10 International Stroke Trial Collaborative Group, International stroke trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. Lancet 1997:349:1569-81.
11. 11 Kunz R, Oxman AD. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials. BMJ 1998;317:1185-90.
12. 12 Liberati A, Himel HN, Chalmers TC. A quality assessment of randomised controlled trials of primary treatment of breast cancer. J Clin Oncol 1986:4:942-51.
13. 13 Ad Hoc Committee on Health Research Relating to Future Intervention Options. Investing in health research and development. Geneva: World Health Organization, 1996.
14. 14 Smith R. Informed consent: the intricacies. BMJ 1997;314:1059-60.
15. 15 Department of Health and Human Services, Food and Drug Administration. Protection of human subjects: informed consent. Fed Reg 1995;60:49086-103.
16. 16 Yates D, Farrell B, Teasdale G, Sandercock P, Roberts I. Corticosteroids in head injury - the CRASH trial. J Accid Emerg Med 1999;16:83-90.
17. 17 www.crash.ucl.ac.uk (accessed 10 Mar 2000).