Design and statistical issues in multicenter trials of severe head injury

Neurological Research

Volumn 23, Issue 2-3, 2001, Pages 190-192

  Choi, S C ^a   Bullock, R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glasgow Coma Scale; Head injury; Randomised clinical trials; Therapy

Indexed keywords

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLASGOW COMA SCALE; HEAD INJURY; HUMAN; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SAMPLING; STATISTICAL ANALYSIS;

CRANIOCEREBRAL TRAUMA; DATA INTERPRETATION, STATISTICAL; GLASGOW COMA SCALE; HUMANS; MULTICENTER STUDIES; RANDOMIZED CONTROLLED TRIALS;

EID: 0035074348     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164101101198325     Document Type: Article

References (8)

1. Primary endpoints in Phase III trials of severe head trauma: DRS versus GOS
2. Sample size in clinical trials with dichotomous endpoints: Use of covariables
3. A multiple testing procedure for clinical trials
4. Group sequential clinical trials with triangular continuation regions
5. Practical problems in collaborative clinical trials
6. Quality of institutional participation in multicenter clinical trials
7. Methodological issues in the design of traumatic brain injury Phase III trials: A call for larger, simpler trials
8. Clinical neuroprotection trials in severe traumatic brain injury: Lessons from previous studies