Unbalanced overexpression of the mutant allele in murine Patched mutants

Carcinogenesis

Volumn 23, Issue 5, 2002, Pages 727-733

  Calzada Wack, Julia ^a,b   Kappler, Roland ^a,b,d   Schnitzbauer, Udo ^a,b   Richter, Thomas ^a   Nathrath, Michaela ^a   Rosemann, Michael ^b   Wagner, Stephan N ^c   Hein, Rüdiger ^a   Hahn, Heidi ^a,b,d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; PROTEIN PATCHED; UNCLASSIFIED DRUG;

ALLELE; ANIMAL TISSUE; ARTICLE; BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; CANCER TISSUE; CARCINOGENESIS; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HAPLOIDY; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHABDOMYOSARCOMA; WILD TYPE;

ALLELES; ANIMALS; BASE SEQUENCE; CARCINOMA, BASAL CELL; DNA PRIMERS; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MICE; MUTATION; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS;

EID: 0036258777     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9
2. Nevoid basal-cell carcinoma syndrome
3. Quinn Human homolog of patched, a candidate gene for the basal cell nevus syndrome
4. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
5. Mutation and cancer: Statistical study of retinoblastoma
6. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
7. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
8. Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein and no genotype-phenotype correlations are evident
9. Developmental genes and cancer: Role of patched in basal cell carcinoma of the skin
10. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
11. Biochemical evidence that patched is the Hedgehog receptor
12. Hedgehog signalling in cancer
13. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
14. Altered neural cell fates and medulloblastoma in mouse patched mutants
15. Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue
16. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
17. Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin
18. Molecular basis of the nevoid basal cell carcinoma syndrome
19. Cancer genetics
20. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors
21. Nevoid basal cell carcinoma syndrome: Molecular biology and new hypotheses
22. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
23. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
24. Feedback control of intercellular signalling in development
25. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system