Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium

Molecular and Cellular Biology

Volumn 22, Issue 12, 2002, Pages 4033-4042

  Ricci, Andrea R ^a   Genereaux, Julie ^a   Brandl, Christopher J ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HISTONE ACETYLTRANSFERASE; PROTEIN ARG1; TATA BINDING PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA FLANKING REGION; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

ACETYLTRANSFERASES; ARGININOSUCCINATE SYNTHASE; BACTERIAL PROTEINS; BASE SEQUENCE; CULTURE MEDIA; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; MCM1 PROTEIN; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ADA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036258095     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.12.4033-4042.2002     Document Type: Article

References (85)

1. Recruitment of the RNA polymerase II holoenzyme and its implications in gene regulation
2. Moderate increase in histone acetylation activates the mouse mammary, tumor virus promoter and remodels its nucleosome structure
3. Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters
4. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
5. Genomewide studies of histone deacetylase function in yeast
6. SAGA is an essential in vivo target of the yeast acidic activator Gal4p
7. Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription
8. Structure/functional properties of the yeast dual regulator protein NGG1 that are required for glucose repression
9. Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate
10. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tral subunit
11. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
12. A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast
13. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
14. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae
15. Arginine-specific repression in Saccharomyces cerevisiae: Kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism
16. Arginine repression of the Saccharomyces cerevisiae ARG1 gene. Comparison of the ARG1 and ARG3 control regions
17. Chromosomal mapping of core histone acetylation by immunoselection
18. Histone acetylation at promoters is differentially affected by specific activators and repressors
19. The regulation of arginine biosynthesis in Saccharomyces cerevisiae. The specificity of argR-mutations and the general control of amino-acid biosynthesis
20. In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter
21. Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: Role of Gln3p, ArgRp-Mcm1p, and Ume6p
22. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae
23. The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein
24. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
25. Chromatin as an essential part of the transcriptional mechanism
26. The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo
27. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
28. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
29. A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
30. The ATM-related cofactor Tral is a component of the purified SAGA complex
31. The SAGA unfolds: Convergence of transcription regulators in chromatin-modifying complexes
32. Histone acetylation in chromatin structure and transcription
33. Molecular genetics of the RNA polymerase II general transcriptional machinery
34. A direct link between core histone acetylation and transcriptionally active chromatin
35. Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction
36. Dissecting the regulatory circuitry of a eukaryotic genome
37. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
38. ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex
39. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3
40. Histone H3 specific acetyltransferases are essential for cell cycle progression
41. A cis- dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae
42. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo
43. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
44. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
45. The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4
46. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription
47. Functional similarity and physical association between GCN5 and ADA2: Putative transcriptional adaptors
48. Transcriptional activation by yeast PDRIp is inhibited by its association with NGG1p/ADA3p
49. Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones
50. Regulation of arginine biosynthesis in Saccharomyces cerevisiae: Isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis
51. Genetic evidence for a role for MCM1 in the regulation of arginine metabolism in Saccharomyces cerevisiae
52. In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex
53. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo
54. yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex
55. Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner
56. Transcriptional regulation of prolactin receptor gene expression by sodium butyrate in MCF·7 human breast cancer cells
57. ADA3: A gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2
58. Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP. A role for the rapid form of histone acetylation
59. Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways
60. Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes
61. SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiae
62. Rad6-dependent ubiquitination of histone H2B in yeast
63. Gcn5p is involved in the acetylation of histone H3 in nucleosomes
64. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
65. Identification of native complexes containing the yeast coactivator/repressor proteins NGG 1/ADA3 and ADA2
66. Tralp is a component of the yeast Ada.Spt transcriptional regulatory complexes
67. Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter
68. Functional organization of the yeast SAGA complex: Distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
69. Histone acetylation and transcriptional regulatory mechanisms
70. Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase
71. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
72. The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcription
73. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
74. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
75. Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
76. Global histone acetylation and deacetylation in yeast
77. Histone acetylation: Chromatin in action
78. Histone acetyltransferases in control
79. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
80. Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
81. The SPT3 gene is required for normal transcription of Ty elements in S. cerevisiae
82. Transcription: In tune with the histones
83. Activators and repressors: Making use of chromatin to regulate transcription
84. Alteration of nucleosome structure as a mechanism of transcriptional regulation