Effects of interferon alpha on the expression of p21cip1/waf1 and cell cycle distribution in carcinoid tumors

Cancer Investigation

Volumn 20, Issue 3, 2002, Pages 348-356

  Zhou, Yinghua ^a   Wang, Shu ^a   Yue, Bai Gong ^b   Gobl, Anders ^a   Oberg, Kjell ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Carcinoid; Cell cycle; Cyclin dependent kinases; Gene expression; Interferon alpha; Neuroendocrine tumor; p21cip1 waf1; Signal transduction

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; CYCLIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 3; CYCLIN DEPENDENT KINASE 4; CYCLIN E; PROTEIN P21; STAT1 PROTEIN; STAT2 PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOID; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NEUROENDOCRINE TUMOR; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CARCINOID TUMOR; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-ALPHA; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 0036256698     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-120001180     Document Type: Article

References (29)

1. A role for the cyclin-dependent kinase inhibitor p21 in the G1 cell cycle arrest mediated by the type I interferons
2. Formation of the early-region-2 transcription-factor-I-retinoblastoma protein (E2F-1-RB) transrepressor and release of the retinoblastoma protein from nuclear complexes containing cyclin A is induced by interferon alpha in U937V cells but not in interferon-alpha-resistant U937VR cells
3. Induction of p21 (WAF-1/CIP1) During Differentiation
4. Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells
5. Involvement of p21 (WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition
6. Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma
7. p21waf1/cip1mda-6 expression in non-small-cell lung cancer: Relationship to survival
8. Immunohistochemical markers of cell cycle control applied to ovarian and primary peritoneal surface epithelial neoplasms: p21 (WAF1/CIP1) predicts survival and good response to platinin-based chemotherapy
9. p21 (WAF1) expression and endocrine response in breast cancer
10. p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer
11. Loss of p21/WAF1/CIP1 expression correlates with disease progression in gastric carcinoma
12. The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus
13. Transcriptional activation of the p21 (WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
14. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation
15. Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer
16. p21 (Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
17. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
18. Chemotherapy and biotherapy in neuroendocrine tumors
19. Interferons alone or in combination with chemotherapy or other biologicals in the treatment of neuroendocrine gut and pancreatic tumors
20. Expression of p68 protein kinase and its prognostic significance during IFN-α therapy in patients with carcinoid tumours
21. Interferon-induced enhancement of 2′5′-oligoadenylate synthetase in mid-gut carcinoid tumours
22. Inhibition of CDK2, CDK4 and cyclin E and increased expression of p27Kip1 during treatment with interferon-α in carcinoid tumor cells
23. Sequences involved in the control of adenovirus L1 alternative RNA splicing
24. UDP-galactose: Ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
25. Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality
26. Complete inhibition of Cdk/Cyclin by one molecule of p21 (Cip 1)
27. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
28. p21WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells
29. p21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation