p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer

British Journal of Cancer

Volumn 79, Issue 11-12, 1999, Pages 1870-1878

  Anttila, M A ^a,b   Kosma, V M ^a,b   Hongxiu, J ^c   Puolakka, J ^d   Juhola, M ^d   Saarikoski, S ^a   Syrjanen K ^a,b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c JOHNS HOPKINS HOSPITAL   (United States)

^d JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

Author keywords

Epithelial ovarian cancer; Ki 67; p21 WAF1; p53; Prognosis

Indexed keywords

PROTEIN P21; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL ANALYSIS;

EID: 0033066666     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690298     Document Type: Article

References (49)

1. Auer G, Einhorn N, Nilsson B, Silfversward C and Sjovall K (1996) Biological malignancy grading in early-stage ovarian carcinoma. Acta Oncol 8: 93-98
2. Backe J, Gassel AM, Hauber K, Krebs S, Bartek J, Caffier H, Kreipe H-H, Muller-Hermelink H-K and Dietl J (1997) p53 protein in endometrial cancer is related to proliferative activity and prognosis but not to expression of p21 protein. Int J Gynecol Pathol 16: 361-368
3. WAF1/CTP1 is heterogeneous and unrelated to proliferation index in human ovarian carcinoma. Int J Cancer 63: 611-615
4. Boring CC, Squires TS, Tong T and Montgomery S (1994) Cancer statistics, 1994. CA Cancer J Clin 44: 7-26
5. Bukholm IK, Nesland JM, Karesen R, Jacobsen U and Borresen AL (1997) Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas. J Pathol 181: 140-145
6. Cancer Committee of the International Federation of Gynecology and Obstetrics (1989) Staging Announcement: FIGO Cancer Committee. Gynecol Oncol 25: 383-385
7. Cox DR (1972) Regression models and life tables with discussion. J Stat Soc B 34: 187-192
8. Diab SG, Yu Y, Hilsenbeck SG, Allred DC and Elledge RM (1997) WAF1/CIP1 protein expression in human breast tumors. Breast Cancer Res Treat 43: 99-103
9. Doglioni C, Pelosio P, Laurino L, Macri E, Meggiolaro E, Favretti F and Barbareschi M (1996) p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: its relationship with differentiation. J Pathol 179: 248-253
10. Elbendary A, Berchuck A, Davis P, Havrilesky I, Bast RC Jr, Iglehart JD and Marks JR (1994) Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ 5: 1301-1307
11. Elbendary AA, Cirisano FD, Evans AC, Davis PL, Iglehart JD, Marks JR and Berchuk A (1996) Relationship between p21 expression and mutation of p53 tumor suppressor gene in normal and malignant ovarian epithelial cells. Clin Cancer Res 2: 1571-1575
12. El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW and Vogelstein B (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174
13. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelslein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825
14. WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55: 2910-2919
15. Engeland A, Haldorsen T, Tretli S, Hakulinen T, Horte LG, Luostarinen T, Schou G, Sigvaldason H, Storm HH and Tulinius H (1995) Prediction of cancer mortality in the Nordic countries up to the years 2000 and 2010, on the basis of relative survival analysis: a collaborative study of five Nordic cancer registries. APMIS Suppl 49: 81-83
16. Finnish Cancer Registry (1997) Cancer incidence in Finland 1995. Cancer statistics of the National Research and Development Center for Welfare and Health. Cancer Society of Finland No. 58
17. Garzetti GG, Ciavattini A, Gotteri G, De Nictolis M, Stramazzotti D, Lucarini G and Biagini G (1995) Ki 67 immunostaining (MIB1 monoclonal antibody) in serous ovarian tumors: index of proliferative activity with prognostic significance. Gynecol Oncol 56: 169-174
18. Gomyo Y, Ikeda M, Osaki M, Tatebe S, Tsujitani S, Ikeguchi M, Kaibara N and Ito H (1997) Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma. Cancer 79: 2067-2072
19. WAF1/CIP1 in pancreatic cancer. Br J Cancer 76: 299-305
20. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816
21. Henriksen R, Strang P, Wilander E, Backstrom T, Tribukait B and Oberg K (1994) p53 expression in epithelial ovarian neoplasms: relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry. Gynecol Oncol 53: 301-306
22. Herod JJ, Eliopoulos AG, Warwick J, Niedobitek G, Young LS and Kerr DJ (1996) The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma. Cancer Res 56: 2178-2184
23. Ito K, Sasano H, Matsunaga G, Sato S, Yajima A, Nasim S and Garret C (1997) Correlations between p21 expression and clinicopathological findings, p53 gene and protein alterations, and survival in patients with endometrial carcinoma. J Pathol 183: 318-324
24. Ito Y, Kobayashi T, Takeda T, Komoike Y, Wakasugi E, Tamaki Y, Tsujimoto M, Matsuura N and Monden M (1996) Expression of p21 (WAF1/CIP1) protein in clinical thyroid tissues. Br J Cancer 74: 1269-1274
25. Jiang H, Lin J, Su ZZ, Collart FR, Huberman E and Fisher PB (1994) Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene 9: 3397-3406
26. Jiang M, Shao ZM, Wu J, Lu JS, Yu LM, Yuan JD, Han QX, Shen ZZ and Fontana JA (1997) p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis. Int J Cancer 74: 529-534
27. Kaplan EL and Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481
28. Klemi PJ, Pylkkänen L, Kiilholma P, Kurvinen K and Joensuu H (1995) p53 protein detected by immunohistochemistry as a prognostic factor in patients with epithelial ovarian carcinoma. Cancer 76: 1201-1208
29. Kohler MF, Kerns BJ, Humphrey PA, Marks JR, Bast RC Jr and Berchuck A (1993a) Mutation and overexpression of p53 in early-stage epithelial ovarian cancer. Obstet Gynecol 81: 643-650
30. Kohler MF, Marks JR, Wiseman RW, Jacobs IJ, Davidoff AM, Clarke Pearson DL, Soper JT, Bast RC Jr and Berchuck A (1993b) Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer. J Natl Cancer Inst 85: 1513-1519
31. Kondo S, Barna BP, Kondo Y, Tanaka Y, Casey G, Liu J, Morimura T, Kaakaji R, Peterson JW, Werbel B and Barrett GH (1996) WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene 13: 1279-1285
32. Levesque MA, Katsaros D, Yu H, Zola P, Sismondi P, Giardina G and Diamandis EP (1995) Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma. Cancer 75: 1327-1338
33. Lukas J, Groshen S, Saffari B, Niu N, Reles A, Wen WH, Felix J, Jones LA, Hall FL, and Press MF (1997) WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium. Am J Pathol 150: 167-175
34. Marchetti A, Doglioni C, Barbareschi M, Buttita F, Pellegrini S, Bertacca G, Chella A, Merlo G, Angeletti CA, Palma PD and Bevilacqua G (1996) p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene 12: 1319-1324
35. Marks JR, Davidoff AM, Kerns BJ, Humphrey PA, Pence JC, Dodge RK, Clarke Pearson DL, Iglehart JD, Bast RC Jr and Berchuck A (1991) Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res 51: 2979-2984
36. WAF1/CIP1 in fetal and adult tissues: simultaneous analysis with Ki67 and p53. J Clin Pathol 50: 645-653
37. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE and Givol D (1994) Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54: 3391-3395
38. WAF1/CIP1 expression correlates with disease progression in gastric carcinoma. Br J Cancer 75: 1617-1620
39. WAF1/CIP1 in normal, hyperplastic, and neoplastic uterine tissues. Hum Pathol 28: 60-66
40. Parker SL, Tong T, Bolden S and Wingo PA (1997) Cancer statistics, 1997. CA Cancer J Clin 47: 5-27
41. Serov SF, Scully R and Sobin LH (1973) Histological typing of ovarian tumours. International Histological Classification of Tumors, no. 9. Geneva: WHO
42. Sheikh MS, Li XS, Chen JC, Shao ZM, Ordonez JV and Fontana JA (1994) Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene 9: 3407-3415
43. Shigemasa K, Hu C, West CM, Moon SH, Parham GP, Parmley TH, Korourian S, Baker VV and O'Brien TJ (1997) p21: a monitor of p53 dysfunction in ovarian neoplasia. Int J Gynecol Cancer 7: 296-303
44. Wakasugi E, Kobayashi T, Tamaki Y, Ito Y, Miyashiro I, Komoike Y, Takeda T, Shin E, Takatsuka Y, Kikkawa N, Monden T and Monden M (1997) p21 (Waf1/Cip1) and p53 protein expression in breast cancer. Am J Clin Pathol 107: 684-691
45. Van der Zee AG, Hollema H, Suurmeijer AJ, Krans M, Sluiter WJ, Willemse PH, Aalders JG and de Vries EG (1995) Value P-glycoprotein, glutathione S-transferase pi, c-erbB-2, and p53 as prognostic factors in ovarian carcinomas. J Clin Oncol 13: 70-78
46. Wan M, Zweizig S, D'Ablaing G, Zheng J, Velicescu M and Dubeau L (1994) Three distinct regions of chromosome 6 are targets of loss of heterozygosity in human ovarian carcinomas. Int J Oncol 5: 1043-1048
47. waf1/cip1 in ovarian carcinomas: correlation with p53 and Ki-67 immunohistochemistry. Int J Gyn Pathol 16: 149-155
48. waf1/cip1 in preinvasive and invasive squamous neoplasms of the uterine cervix. Mod Pathol 10: 578-584
49. Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB and Mercer WE (1995) p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55: 668-674