Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces

Journal of Antibiotics

Volumn 55, Issue 4, 2002, Pages 407-416

  Waters, Barbara ^a   Saxena, Geeta ^a   Waggui, Yangsheng ^a   Kau, David ^a   Wrigley, Stephen ^a   Stokes, Richard ^a   Davies, Julian ^a  

^a Cubist Pharmaceuticals Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BENZO[K]FLUORANTHENE; BERNINAMYCIN A; BREFELDIN A; CYCLOMARIN A; DEPSIDOMYCIN; ERIZOMYCIN; GELDANAMYCIN; GENISTEIN; LACTONE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDOMYCIN; PYRROLE DERIVATIVE; SURFACTIN; TYRPHOSTIN; UNCLASSIFIED DRUG; VISCOSIN;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; EUKARYOTIC CELL; FUNGUS HYPHAE; GENE IDENTIFICATION; GROWTH INHIBITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRAIN IDENTIFICATION; STREPTOMYCES;

MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES;

EID: 0036253141     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.407     Document Type: Article

References (40)

1. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
2. Protein modules and signalling networks
3. Protein phosphorylation and regulation of adaptive responses in bacteria
4. Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay
5. Tyrosine kinase activity in Pseudomonas aeruginosa
6. Protein tyrosine phosphorylation in Mycobacterium tuberculosis
7. Protein tyrosine phosphorylation in streptomycetes
8. Cloning, purification and properties of phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)
9. Tyrosine phosphorylation in Myxococcus xanthus, a multicellular prokaryote
10. Bacterial signalling involving eukaryotic-type protein kinases
11. Signal transduction as a drug discovery program
12. Tyrosine kinase inhibition: An approach to drug development
13. Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus
14. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumour antibiotics radicicol and geldanamycin
15. Identification of Bacteroides species by cellular fatty acid profiles
16. 16S/23S rRNA sequencing
17. The ribosomal database project
18. Basic local alignment tool
19. Method and composition for identifying inhibitors of eukaryotic cell processes
20. Massetolides A-H, Antimycobacterial cyclic depsipeptides produced by two Pseudomonads isolated from marine habitats
21. Depsidomycin, a new immunomodulating antibiotic
22. Antibiotic berninamycin and process for making same
23. Antibiotic erizomycin and process for making same
24. Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities
25. Inhibition of endotoxin-induced TNFα production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorccyclic acid lactones
26. A novel (6S)-4,6-dimethyldodeca-2E,4E-dienoyl ester of phomalactone and related α-pyrone esters from a Phomopsis sp. with cytokine production inhibitory activity
27. Differential regulation of CD3- and CD28-induced IL-2 and IFNγ production by a novel tyrosine kinase inhibitor XR-774 from Cladosporium cf. cladosporioides
28. Components of eukaryotic-like signaling pathways in Mycobacterium tuberculosis
29. Signal transduction cascades as targets for therapeutic intervention by natural products
30. Two-component signal transduction as a target for microbial anti-infective therapy
31. Screening of microbial extracts for tyrosine kinase inhibitors
32. Calcium signal modulators inhibit aerial mycelium formation in Streptomyces alboniger
33. srfA is an operon required for surfactin production, competence development and efficient sporulation in B. subtilis
34. Purification and structural determination of an inhibitor of starfish oocyte maturation from a Bacillus species
35. No longer an exclusive club: Eukaryotic signalling domains in bacterial
36. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis
37. Engineered biosynthesis of peptide antibiotics
38. A protein kinase inhibitor as an antimycobacterial agent
39. Fancy meeting you here! A fresh look at "prokaryotic" protein phosphorylation