Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 9, 2002, Pages 1134-1141

  Ishii, Masakazu ^a,b   Shimizu, Shunichi ^a   Shiota, Kazuhiro ^a   Yamamoto, Shinichiro ^a   Kiuchi, Yuji ^a   Yamamoto, Toshinori ^a  

^a SHOWA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Cyclosporin A; Endothelial cells; GTP cyclohydrolase I; Nitric oxide synthase; Tetrahydrobiopterin

Indexed keywords

ARGININE; CITRULLINE; CYCLOHEXIMIDE; CYCLOSPORIN A; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; IMMUNOSUPPRESSIVE AGENT; MARKER; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROTEIN SYNTHESIS INHIBITOR; REACTIVE OXYGEN METABOLITE; TETRAHYDROBIOPTERIN;

AMINO ACID SYNTHESIS; ANIMAL CELL; ARTICLE; BRAIN; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INDUCTION; GENE EXPRESSION; GENETIC ANALYSIS; MOUSE; NONHUMAN; PROTEIN ANALYSIS; SYNTHESIS;

ANIMALS; ANTIOXIDANTS; ARGININE; BIOPTERIN; CEREBROVASCULAR CIRCULATION; CYCLOHEXIMIDE; CYCLOSPORINE; ENDOTHELIUM, VASCULAR; GTP CYCLOHYDROLASE; IMMUNOSUPPRESSIVE AGENTS; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN SYNTHESIS INHIBITORS;

EID: 0036252614     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00033-X     Document Type: Article

References (29)

1. Cerebral blindness and encephalopathy with cyclosporin A toxicity
2. N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats
3. Role of nitric oxide in cyclosporine A-induced hypertension
4. Nitric oxide in cyclosporine A-induced hypertension: Role of protein kinase C
5. Prevention by selenium supplementation of cyclosporin-A-induced vascular toxicity
6. Cyclosporine produces endothelial dysfunction by increased production of superoxide
7. Cyclosporin-induced endothelial dysfunction and hypertension: Are nitric oxide system abnormality and oxidative stress involved?
8. CsA and FK506 up-regulate eNOS expression: Role of reactive oxygen species and AP-1
9. Transcriptional induction of endothelial nitric oxide gene by cyclosporine A: A role for activator protein-1
10. Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
11. Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content
12. Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (review)
13. 2-induced endothelial cell injury
14. Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta
15. Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells
16. 5-Hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures
17. Effects of β-amyloid on nitric oxide production in brain microvascular endothelial cells
18. Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle cells
19. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle
20. Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production
21. Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages
22. Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta
23. Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death
24. SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin
25. Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D, L-penicillamine induced endothelial cell injury
26. Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes
27. Does cyclosporin a generate free radicals?
28. Metabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells
29. The nitric oxide synthase cofactor tetrahydrobiopterin reduces allograft ischemia-reperfusion injury after lung transplantation