Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells

Japanese Journal of Pharmacology

Volumn 87, Issue 1, 2001, Pages 51-60

  Shimizu, S ^a   Ishii, M ^a   Iwasaki, M ^a   Shiota, K ^a   Yamamoto, T ^a   Kiuchi, Y ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Carboxy PTIO; GTP cyclohydrolase I; Lipopolysaccharide; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; ARGININE; BIOPTERIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; LIPOPOLYSACCHARIDE; MESSENGER RNA; N ACETYLSEROTONIN; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PTERIN; PYRIMIDINE DERIVATIVE; SCAVENGER; SEPIAPTERIN REDUCTASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME SYNTHESIS; MOUSE; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

EID: 0034798075     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.87.51     Document Type: Article

References (46)

1. Vascular endothelial cells synthesize nitric oxide from L-arginine
2. 2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase
3. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells
4. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
5. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
6. Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages
7. Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium
8. An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide
9. Role of nitric oxide in the vascular dysfunction of septic shock
10. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo
11. Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure
12. Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin
13. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia
14. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
15. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
16. Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide-mediated killing
17. Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase
18. Nitric oxide and oxygen radicals in infection, inflammation, and cancer
19. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
20. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: Characterization, sequence and relationship to nitric oxide synthase
21. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle
22. GTP cyclohydrolases: A review
23. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin
24. Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in resulting their association into a dimeric enzyme
25. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer
26. Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase
27. Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes
28. Modulation of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) induced HL-60 cell death by tetrahydrobiopterin
29. 2-induced endothelial cell injury
30. Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death
31. Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta
32. Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide
33. Beneficial effect of carboxy-PTIO on hemodynamic and blood gas changes in septic shock dogs
34. 1H magnetic resonance spectroscopic study
35. Effects of nitric oxide scavenger, carboxy-PTIO on endotoxin-induced alterations in systemic hemodynamics in rats
36. Analysis of reduced forms of biopterin in biological tissues and fluids
37. SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin
38. L-Ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
39. N-Nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases
40. Dependence of endotoxin-induced vascular hyporeactivity on extracellular L-arginine
41. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction
42. Reduced pterins as scavenger for reactive oxygen species
43. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions
44. Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins
45. The role of nitric oxide in human pulmonary artery endothelial cell injury mediated by neutrophils
46. The protective role of thiols against nitric oxide-mediated cytotoxicity in murine macrophage J774 cells