CsA and FK506 up-regulate eNOS expression: Role of reactive oxygen species and AP-1

Kidney International, Supplement

Volumn 54, Issue 68, 1998, Pages

  Navarro Antolin, J ^a   Hernandez Perera, O ^a   Lopez Ongil, S ^a   Rodriguez Puyol, M ^a   Rodriguez Puyol, D ^a   Lamas, S ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

AP 1; Cyclosporine A; Endothelial NOS; Reactive oxygen species; Transcription

Indexed keywords

CATALASE; CYCLOSPORIN A; GLUCOSE OXIDASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; TACROLIMUS; TRANSCRIPTION FACTOR AP 1; CALCINEURIN; CYCLOSPORIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERTENSION; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; AORTA; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NORTHERN BLOTTING; OXIDATION REDUCTION REACTION;

ANIMALS; AORTA; BLOTTING, NORTHERN; CALCINEURIN; CATALASE; CATTLE; CELLS, CULTURED; CYCLOSPORINE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE OXIDASE; IMMUNOSUPPRESSIVE AGENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TACROLIMUS; TRANSCRIPTION FACTOR AP-1;

EID: 0031742104     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.06807.x     Document Type: Article

References (26)

1. 2 synthesis induced by cyclosporine A Am J Physiol 251 1986 F581 F587 Renal Fluid Electrol Physiol 20
2. C. Zoja L. Furci F. Ghilardi P. Zinio A. Benigni G. Remuzzi Cyclosporine-induced endothelial cell injury Lab Invest 55 1986 455 461
3. T.E. Bunchman C.A. Brookshire Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells J Clin Invest 88 1991 310 314
4. Y. Takeda T. Yoneda Y. Ito I. Miyamori R. Takeda Stimulation of endothelin mRNA and secretion in human endothelial cells by FK506 J Cardiovas Pharmacol 22 1993 S310 S312
5. C. Bossaller U. Forstermann R. Hertd C. Olbricht V. Reschke E. Fleck CsA inhibits endothelium-dependent vasodilatation and vascular prostacyclin production Eur J Pharmacol 165 1989 165 169
6. H.S. Cairns L.D. Fairbanks J. Westwick G.H. Neil Cyclosporin therapy in vivo attenuates the response to vasodilators in the isolated rabbit kidney Br J Pharmacol 98 1989 463 468
7. B.E. Bierer G. Hollander D. Fruman S.J. Burakoff Cyclosporin A and FK506: Molecular mechanisms of immunosuppression and probes for transplantation biology Curr Opin Immunol 5 1993 763 773
8. J. Jain P.G. Mc Caffrey Z. Miner T.K. Kerppola J.N. Lambert G.L. Verdine T. Curran A. Rao The T-cell transcription factor NF-ATp is a substrate for calcineurin and interacts with Fos and Jun Nature 365 1993 352 355
9. J.S. Stamler D.J. Singel J. Loscalzo Biochemistry of nitric oxide and its redox-activated forms Science 258 1992 1898 1902
10. S.S. Ahmed H.W. Strobel K.L. Napoli J. Grevel Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes J Pharmacol Exp Ther 265 1993 1047 1054
11. C. Wang A.K. Salahudeen Lipid peroxidation accompanies cyclosporine nephrotoxicity: Effects of vitamin E Kidney Int 47 1995 927 934
12. M.S. Paller Free radical scavengers in mercury chloride-induced acute renal failure in the rat J Lab Clin Med 105 1995 459 463
13. H.M. Lander An essential role for free radicals and derived species in signal transduction FASEB J 11 1997 118 124
14. M. Sundaresan Z.X. Yu V.J. Ferrans K. Irani T. Finkel Requirement for generation of hydrogen peroxide for platelet-derived growth factor signal transduction Science 270 1995 296 299
15. R. Schreck P. Rieber P.A. Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF- κ B transcription factor and HIV-1 EMBO J 10 1991 2247 2258
16. M. Meyer R. Schreck P.A. Baeuerle Hydrogen peroxide and antioxidants have opposite effects on activation of NF- κ B and AP-1 in intact cells: AP-1 as secondary antioxidant responsive factor EMBO J 12 1993 2005 2015
17. S.K. Sen L. Packer Antioxidant and redox regulation of gene transcription FASEB J 10 1996 709 720
18. S. López-Ongil M. Saura D. Rodríguez-Puyol M. Rodríguez-Puyol S. Lamas Regulation of endothelial NO synthase expression by cyclosporin A in bovine aortic endothelial cells Am J Physiol 271 1996 H1072 H1078
19. S. Lamas T. Michel B. Brenner P.A. Marsden Nitric oxide synthesis in endothelial cells: Evidence for a pathway inducible by tumor necrosis factor-alpha Am J Physiol 261 1991 C634 C641
20. D.A. Bass J.W. Parce L.R. De Chatelet P. Szejda M.C. Seeds M. Thomas Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation J Immunol 130 1983 1910 1917
21. P. Chomczynski N. Sacchi Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
22. S. Lamas T. Michel T. Collins B.M. Brenner P.A. Marsden Effects of interferon-γ on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells J Clin Invest 90 1992 879 887
23. S. Lamas P.A. Marsden G.K. Li P. Tempst T. Michel Endothelial nitric oxide synthase: Molecular cloning and characterisation of a distinct constitutive enzyme isoform Proc Natl Acad Sci USA 89 1992 6348 6352
24. E. Schreiber P. Matthias M.M. Müller W. Schaffner Rapid detection of octamer binding proteins with “mini-extracts” prepared from small number of cells Nucl Acids Res 17 1989 6419
25. Q. Su H.P. Eugster B. Ryffel F.J. Dumant Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma Biochem Biophys Res Commun 229 1996 249 256
26. S.D. Goldstone J.C. Fragonas T.M. Jeitner N.H. Hunt Transcription factors as targets for oxidative signalling during lymphocyte activation Biochim Biophys Acta 1263 1995 114 122