Progressive defect of insulin action on glycogen synthase in obesity and diabetes

Metabolism: Clinical and Experimental

Volumn 51, Issue 5, 2002, Pages 549-553

  Golay, Alain ^a,b   Munger, Robert ^a,b   Assimacopoulos Jeannet, Françoise ^a,b   Bobbioni Harsch, Elisabetta ^a,b   Habicht, Frank ^a,b   Felber, Jean Pierre ^a,b  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE; INSULIN;

ADULT; ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE OXIDATION; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; MALE; METABOLIC DISORDER; MUSCLE BIOPSY; NEEDLE BIOPSY; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0036251664     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2002.31972     Document Type: Article

References (27)

1. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis
2. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catherization
3. Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type 2 diabetes
4. The disposal of an oral glucose load in patients with non-insulin-dependent diabetes
5. The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle
6. 13C nuclear magnetic resonance spectroscopy
7. 13C/31P NMR studies on the mechanism of insulin resistance in obesity
8. Impaired glucose transport as a cause of degraded insulin stimulated muscle glycogen synthesis in type 2 diabetes
9. Mechanism of free fatty acid-induced insulin resistance in humans
10. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
11. Correlation between muscle glycogen synthase activity and in vivo insulin action in man
12. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography
13. Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle
14. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
15. New insights in the role and mechanism of glycogen synthase activation by insulin
16. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
17. Assessment of fat-free mass using bioelectrical impedance measurements of the human body
18. Glucose clamp technique: A method for quantifying insulin secretion and resistance
19. Correlations of glycogen synthase and phosphorylase activities with glycogen concentration in human muscle biopsies. Evidence for a double feed-back mechanism regulating glycogen synthesis and breakdown
20. Glycogen synthase: A new activity ratio assay expressing a high sensitivity to the phosphorylation state
21. Kjeldahl method
22. Coated charcoal immunoassay of insulin
23. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms
24. Protein kinase B (PKB/Akt) - A key regulator of glucose transport?
25. Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis
26. Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle
27. Glucose toxicity