Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis

British Journal of Haematology

Volumn 117, Issue 2, 2002, Pages 427-435

  Harrison, Christine J ^a,d   Mazzullo, Helen ^a   Ross, Fiona M ^b   Cheung, Kan L ^a,d   Gerrard, Gareth ^a   Harewood, Louise ^a,b,c,d   Mehta, Atul ^a   Lachmann, Helen J ^c   Hawkins, Philip N ^c   Orchard, Kim H ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b SALISBURY DISTRICT HOSPITAL   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

13q deletions; Fluorescence in situ hybridization; IGH rearrangements; Primary amyloidosis

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

ADULT; AGED; AMYLOIDOSIS; ARTICLE; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE FUSION; GENE IDENTIFICATION; GENE LOCATION; GENE LOSS; GENE REARRANGEMENT; GENE TRANSLOCATION; HEAVY CHAIN DISEASE; HUMAN; IN SITU HYBRIDIZATION; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PLASMA CELL DYSCRASIA; PLASMA CELL LEUKEMIA; PRIORITY JOURNAL;

ADULT; AGED; AMYLOIDOSIS; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 14; FEMALE; GENE DELETION; GENES, IMMUNOGLOBULIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; TRANSLOCATION, GENETIC;

EID: 0036248412     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03438.x     Document Type: Article

References (39)

1. High incidence of translocations t (11; 14) (q13;q32) and t (4; 14) (p16;q32) in patients with plasma cell malignancies
2. 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma
3. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma
4. Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13
5. 14q32 chromosomal translocations: A hallmark of plasma cell dyscrasias?
6. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
7. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations
8. Frequent monoallelic loss of D13S319 in multiple myeloma patients shown by interphase fluorescence in situ hybridization
9. Factors influencing the false positive and negative rates of BCR- ABL fluorescence in situ hybridization
10. Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines
11. The t (4; 14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
12. Cytogenetic data in 41 patients with multiple myeloma. Karyotype and other clinical parameters
13. Deletion of the retinoblastoma gene in multiple myeloma
14. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
15. Multiple myeloma: High incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization
16. Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance
17. Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy
18. Chromosomal abnormalities in systemic amyloidosis
19. Plasma cell karyotype in multiple myeloma
20. Cytogenetics in multiple myeloma and plasma cell leukemia: Simultaneous cytogenetic and cytologic studies in 51 patients
21. Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis
22. Variable breakpoints in Burkitt lymphoma cells with chromosomal t (8; 14) translocation separate c-myc and the IgH locus up to several hundred kb
23. An optimized set of human telomere clones for studying telomere integrity and architecture
24. Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance
25. Primary systemic amyloidosis: Clinical and laboratory features in 474 cases
26. Improved cytogenetics in multiple myeloma: A study of 151 patients including 117 patients at diagnosis
27. Detection of t (4; 14) (p16.3; q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts
28. The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization
29. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes
30. Biological features of the clone involved in primary amyloidosis (AL)
31. Translocation t (4; 14) (p16.3; q32) is a recurrent genetic lesion in primary amyloidosis
32. Diagnostic utility of fluorescence in situ hybridization in mantle-cell lymphoma
33. A novel chromosomal translocation t (4; 14) (p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
34. Cytogenetic findings in 200 patients with multiple myeloma
35. Prognostic value of cytogenetics in multiple myeloma
36. Chromosomal analysis in multiple myeloma: Cytogenetic evidence of two different diseases
37. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities
38. Monoclonal gammopathy of undetermined significance: Chromosome changes are a common finding within bone marrow plasma cells
39. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridisation