Novel insights into class switch recombination

Current Opinion in Allergy and Clinical Immunology

Volumn 2, Issue 2, 2002, Pages 147-151

  Vercelli, Donata ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DNA; CYTIDINE DEAMINASE; IMMUNOGLOBULIN E; INTERLEUKIN 4;

ANTIGENICITY; B LYMPHOCYTE; DNA STRUCTURE; DNA TRANSCRIPTION; IMMUNE RESPONSE; MOLECULAR MECHANICS; PRIORITY JOURNAL; REVIEW; RNA EDITING;

EID: 0036245456     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200204000-00011     Document Type: Review

References (38)

1. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
2. IgE and its regulators
3. Molecular processes that regulate class switching
4. Unique and unprecedented recombination mechanisms in class switching
5. Molecular regulation of class switch recombination to IgE through germline transcription
6. A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
7. CD40 and IgE: Synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells
8. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function
9. Sequential switching from μ to ε via γ4 in human B cells stimulated with IL-4 and hydrocortisone
10. To E or not to E? Can an IL-4-induced B cell choose between IgE and IgG4?
11. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
12. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
13. Switch transcripts in immunoglobulin class switching
14. Processing of switch transcripts is required for targeting of antibody class switch recombination
15. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
16. Quantitative regulation of class switch recombination by switch region transcription
17. Palindromic but not G-rich sequences are targets of class switch recombination
18. Variale deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class switch recombination
19. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
20. Localisation of IgE synthesis in immediate-type allergy to the upper respiratory tract
21. Local specific IgE production in nasal polyps associated with negative skin tests and serum RAST
22. Immunoglobulins in nasal secretions and nasal mucosa in perennial rhinitis
23. T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis
24. IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: Comparison with IL-4 expression and modulation by topical glucocorticoid therapy
25. Activated T cells in the nasal mucosa of patients with grass-pollen allergy: A pilot study
26. Induction of human IgE synthesis in B cells by mast cells and basophils
27. CD40 ligand is functionally expressed on human eosinophils
28. Nasal mast cells in perennial allergic rhinitis exhibit increased expression of the FcεRI, CD40L, and IL-13, and can induce IgE synthesis in B cells
29. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived
30. Localization of interleukin (IL)-4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy
31. Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
32. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms
33. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern
34. Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching
35. Expression of ε germ-line gene transcripts and mRNA for the ε heavy chain of IgE in nasal B cells and the effects of topical corticosteroid
36. Expression of IL-4, Cε, RNA, and Iε RNA in the nasal mucosa of patients with seasonal rhinitis: Effect of topical corticosteroids
37. Local expression of ε germline gene transcripts and RNA for the c heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma
38. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria