Microtubule-dependent regulation of vasomotor tone requires Rho-kinase

Journal of Vascular Research

Volumn 39, Issue 2, 2002, Pages 173-182

  Platts, Steven H ^a   Martinez Lemus, Luis A ^a   Meininger, Gerald A ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Adenosine; Calcium; Cell signaling; Contraction; Cytoskeleton; Norepinephrine; Vascular reactivity; Vascular smooth muscle; Vasoconstriction; Vasodilation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE; CALCIUM ION; CALCIUM SENSITIZER; DEMECOLCINE; ENZYME INHIBITOR; NORADRENALIN; PROTEIN; PROTEIN SRC; PROTEIN TYROSINE KINASE; RHO KINASE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL TISSUE; ARTERIOLE; ARTERY BLOOD FLOW; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CANNULATION; CELL DISRUPTION; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG EFFECT; ENZYME INHIBITION; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SMOOTH MUSCLE CONTRACTION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASOMOTOR REFLEX;

ADENOSINE; ADP RIBOSE TRANSFERASES; AMIDES; ANIMALS; ARTERIOLES; BOTULINUM TOXINS; CALCIUM; DEMECOLCINE; ENZYME INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROTUBULES; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; NOREPINEPHRINE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASODILATION; VASOMOTOR SYSTEM; VINBLASTINE;

EID: 0036244810     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000057765     Document Type: Article

References (29)

1. Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed
2. Microtubules regulate pulmonary vascular smooth muscle contraction
3. I in porcine coronary arteries
4. Alteration of microtubule polymerization modulates arteriolar vasomotor tone
5. Effect of disruption of the cytoskeleton on smooth muscle contraction
6. Tensegrity: The architectural basis of cellular mechano-transduction
7. Mechano-chemical transduction across extracellular matrix and through the cytoskeleton
8. Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction
9. From pharmaco-mechanical coupling to G-proteins and myosin phosphatase
10. Pharmacomechanical coupling: The role of calcium, G-proteins, kinases and phosphatases
11. Effectors for the Rho GTPases
12. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
13. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
14. Calcium sensitization of smooth muscle mediated by Rho-associated protein kinase in hypertension
15. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: Comparison with protein kinase C
16. Discovery of a novel, potent, and Src-family-selective tyrosine kinase inhibitor
17. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors
18. Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain
19. Role of microtubules in contractile dysfunction of hypertrophied cardiocytes
20. Tubulin, Gq and phosphatidylinositol 4,5-bisphosphate interact to regulate phospholipase Cβ1 signaling
21. Exchange of guanine nucleotides between tubulin and GTP-binding proteins that regulate adenylate cyclase: Cytoskeletal modification of neuronal signal transduction
22. iγ1
23. Pharmacological probes of microtubule function
24. ATP channels
25. Microtubules and signal transduction
26. 2+ sensitivity of contractile elements in coronary arterial smooth muscle
27. Characterization of p190RhoGEF: A RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
28. Involvement of microtubules in the control of adhesion-dependent signal transduction
29. Angiotensin II signal transduction in vascular smooth muscle: Role of tyrosine kinases