Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 5, 2002, Pages 1422-1428

  Chandrasekher, Gudiseva ^a   Ma, Xiang ^a   Lallier, Thomas E ^a   Bazan, Haydee E P ^a  

^a LSU EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2 CHLOROPHENYL) 4,7,8,10 TETRAHYDRO 9 (4 METHOXYPHENYLCARBAMOYL) 1 METHYLPYRIDO[4',3':4,5]THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; 6 (2 CHLOROPHENYL) 9 [(3,4 DIMETHOXYPHENYL)THIOMETHYLTHIOCARBONYL] 4,7,8,10 TETRAHYDRO 1 METHYLPYRIDO[4',3':4,5]THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; BN 50727; COLLAGEN TYPE 1; COLLAGEN TYPE 4; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; KERATINOCYTE GROWTH FACTOR; LAMININ; SCATTER FACTOR; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA CELL; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA OPACITY; EXTRACELLULAR MATRIX; EYE INFLAMMATION; INFLAMMATION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RABBIT; VISUAL ACUITY; WOUND HEALING;

ANIMALS; APOPTOSIS; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CORNEAL STROMA; EPITHELIUM, CORNEAL; FIBROBLASTS; HUMANS; IN SITU NICK-END LABELING; ORGAN CULTURE TECHNIQUES; PHOSPHOLIPID ETHERS; RABBITS; WOUND HEALING;

EID: 0036242445     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Platelet-activating factor: A mediator for clinicians
2. Platelet-activating factor (PAF) accumulation correlates with injury in the cornea
3. The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: Homeostatic mechanisms
4. Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases
5. PAF binds to a single receptor in corneal epithelium plasma membrane
6. Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium
7. 2/cyclooxygenase cascade in the rabbit cornea
8. A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet-activating factor (PAF) in corneal epithelium
9. Platelet-activating factor induces collagenase expression in corneal epithelial cells
10. Platelet-activating factor induces the expression of metalloproteinases-1 and -9, but not -2 or -3, in the corneal epithelium
11. Platelet-activating factor enhances urokinase-type plasminogen activator (UPA) gene expression in corneal epithelium
12. The plasminogen activation in tumor growth, invasion, and metastasis
13. Increased platelet-activating factor receptor gene expression by corneal epithelial wound healing
14. Expression of HGF, KGF, EGF receptor messengers RNAs following corneal epithelial wounding
15. Human recombinant epidermal growth factor in experimental corneal wound healing
16. Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo
17. Topical treatment with nerve growth factor for corneal neurotrophic ulcers
18. Epithelial injury induces keratocyte apoptosis: Hypothesized role for the interleukin-2 system in the modulation of corneal tissue organization and wound healing
19. Corneal epithelial wound healing increases the expression but not long lasting activation of the p85α subunit of phosphatidylinositol 3-kinase
20. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: Maintenance of the keratocyte phenotype in culture
21. Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea
22. Keratocyte apoptosis after corneal surgery
23. Growth factors: Importance in wound healing and maintenance of transparency in the cornea
24. Platelet-activating factor: Improvement in wound healing by a chemotactic factor
25. Current concepts in wound healing: Growth factor and macrophage interaction
26. Stromal changes following removal of epithelium in the cornea
27. Novel aspects of the ultrastructural organization of human corneal keratocytes
28. Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop
29. Plateletactivating factor: A phospholipid autocoid with diverse actions
30. Contact and adhesive specificities in the associations, migration and targeting of cells and axons
31. Intefrin and cadherin synergy regulates contact inhibition of migration and motile activity
32. Unique regulation of the matrix metalloproteinase, gelatinase B
33. Corneal stimulation of MMP-1, -9, and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites