메뉴 건너뛰기




Volumn 18, Issue 3, 1999, Pages 168-176

Corneal epithelial wound healing increases the expression but not long lasting activation of the p85α suhunit of phosphatidylinositol-3 kinase

Author keywords

Corneal epithelium; In vivo wound healing; p85 expression; Phosphatidylinositol 3 kinase; PI 3K inhibitors; Rabbit

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ENZYME INHIBITOR; GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE KINASE RECEPTOR; WORTMANNIN;

EID: 0032936995     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.18.3.168.5372     Document Type: Article
Times cited : (19)

References (42)
  • 1
    • 0002645285 scopus 로고
    • Neurophysiology and pathologic response of corneal and conjunctival disease
    • Smolin, G., Thoft, R. A., eds.
    • Kenyon, K. R., Chaves, H. V. (1994) Neurophysiology and pathologic response of corneal and conjunctival disease. In Smolin, G., Thoft, R. A., eds. The Cornea, Little, Brown and Co, USA, 69-111.
    • (1994) The Cornea, Little, Brown and Co, USA , pp. 69-111
    • Kenyon, K.R.1    Chaves, H.V.2
  • 2
    • 0021950989 scopus 로고
    • Inflammation-induced stimulation of the synthesis of prostaglandins and lipoxygenase-reaction products in rabbit cornea
    • Bazan, H. E. P., Birkle, D. L., Beuerman, R., Bazan, N. G. (1985) Inflammation-induced stimulation of the synthesis of prostaglandins and lipoxygenase-reaction products in rabbit cornea. Curr. Eye Res. 4, 175-179.
    • (1985) Curr. Eye Res. , vol.4 , pp. 175-179
    • Bazan, H.E.P.1    Birkle, D.L.2    Beuerman, R.3    Bazan, N.G.4
  • 3
    • 0023096404 scopus 로고
    • Comeal injury alters eicosanoid formation in the rabbit anterior segment in vivo
    • Bazan, H. E. P. (1987) Comeal injury alters eicosanoid formation in the rabbit anterior segment in vivo. Invest. Ophthalmol. Vis. Sci. 28, 314-319.
    • (1987) Invest. Ophthalmol. Vis. Sci. , vol.28 , pp. 314-319
    • Bazan, H.E.P.1
  • 4
    • 0025865484 scopus 로고
    • Platelet-activating factor (PAF) accumulation correlates with injury in the cornea
    • Bazan, H. E. P., Reddy, S. T K., Lin, N. (1991) Platelet-activating factor (PAF) accumulation correlates with injury in the cornea. Exp. Eye Res. 52, 481-491
    • (1991) Exp. Eye Res. , vol.52 , pp. 481-491
    • Bazan, H.E.P.1    Reddy, S.T.K.2    Lin, N.3
  • 5
    • 0030892129 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet-activating factor (PAF) in corneal epithelium
    • Bazan, H. E. P., Varner, L. (1997) A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet-activating factor (PAF) in corneal epithelium. Curr. Eye Res. 16, 372-379.
    • (1997) Curr. Eye Res. , vol.16 , pp. 372-379
    • Bazan, H.E.P.1    Varner, L.2
  • 6
    • 0026480003 scopus 로고
    • Protein kinase C sub-species in rabbit corneal epithelium: Increased activity of α subspecies during wound healing
    • Lin, N., Bazan, H. E. P. (1992) Protein kinase C sub-species in rabbit corneal epithelium: Increased activity of α subspecies during wound healing. Curr. Eye Res. 11, 899-907.
    • (1992) Curr. Eye Res. , vol.11 , pp. 899-907
    • Lin, N.1    Bazan, H.E.P.2
  • 7
    • 85069277015 scopus 로고    scopus 로고
    • Selective changes in protein kinase (PKC) isoform expression in rabbit corneal epithelium during wound healing. Inhibition of corneal epithelial repair by PKCα antisense
    • in press
    • Chandrasekher, G., Bazan, N. G., Bazan, H. E. P. Selective changes in protein kinase (PKC) isoform expression in rabbit corneal epithelium during wound healing. Inhibition of corneal epithelial repair by PKCα antisense. Exp. Eye Res. (in press).
    • Exp. Eye Res.
    • Chandrasekher, G.1    Bazan, N.G.2    Bazan, H.E.P.3
  • 9
    • 0029789160 scopus 로고    scopus 로고
    • Tear EGF concentration following corneal epithelial wound creation
    • Sheardown, H., Cheng, Y. (1996) Tear EGF concentration following corneal epithelial wound creation. J. Ocul. Pharmacol. Therap. 12, 239-243.
    • (1996) J. Ocul. Pharmacol. Therap. , vol.12 , pp. 239-243
    • Sheardown, H.1    Cheng, Y.2
  • 10
    • 0027375470 scopus 로고
    • Regional variation in distribution of EGF receptor in developing and adult corneal epithelium
    • Zieske, J. D., Wasson, M. (1993) Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J. Cell. Sci. 106, 145-152.
    • (1993) J. Cell. Sci. , vol.106 , pp. 145-152
    • Zieske, J.D.1    Wasson, M.2
  • 11
    • 0027284076 scopus 로고
    • Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea
    • Wilson, S. E., Walker, J. W., Chwang, E. L., He, Y. (1993) Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. Invest. Ophthal. Vis. Sci. 34, 2544-2561.
    • (1993) Invest. Ophthal. Vis. Sci. , vol.34 , pp. 2544-2561
    • Wilson, S.E.1    Walker, J.W.2    Chwang, E.L.3    He, Y.4
  • 12
    • 0029780246 scopus 로고    scopus 로고
    • Differential regulation of cytokine and receptor transcript expression in human corneal and limbal fibroblasts by epidermal growth factor, transforming growth factor-α, platelet-derived growth factor b, and interleukin-1β
    • Li, D. Q., Tseng, S. C. (1996) Differential regulation of cytokine and receptor transcript expression in human corneal and limbal fibroblasts by epidermal growth factor, transforming growth factor-α, platelet-derived growth factor b, and interleukin-1β. Invest. Ophthal. Vis. Sci. 37, 2068-2080.
    • (1996) Invest. Ophthal. Vis. Sci. , vol.37 , pp. 2068-2080
    • Li, D.Q.1    Tseng, S.C.2
  • 14
    • 0027366440 scopus 로고
    • Agonist-stimulated synthesis of phosphatidylinositol (3, 4, 5)-trisphosphate: A new intracellular signaling system?
    • Stephens, L. R., Jackson, T. R., Hawkins, P. T. (1993) Agonist-stimulated synthesis of phosphatidylinositol (3, 4, 5)-trisphosphate: a new intracellular signaling system? Biochem. Biophys. Acta. 1179, 27-75.
    • (1993) Biochem. Biophys. Acta , vol.1179 , pp. 27-75
    • Stephens, L.R.1    Jackson, T.R.2    Hawkins, P.T.3
  • 15
    • 0030790548 scopus 로고    scopus 로고
    • Using structure to define the function of phosphoinositide 3- Kinase family members
    • Domin, J., Waterfield, M. D. (1997) Using structure to define the function of phosphoinositide 3- kinase family members. FEBS Lett. 410, 91-95.
    • (1997) FEBS Lett. , vol.410 , pp. 91-95
    • Domin, J.1    Waterfield, M.D.2
  • 16
    • 0028800996 scopus 로고
    • PIK-related kinases: DNA repair, recombination, and cell cycle check-points
    • Keith, C. T., Schreiber, S. L. (1995) PIK-related kinases: DNA repair, recombination, and cell cycle check-points. Science. 270, 50-51.
    • (1995) Science , vol.270 , pp. 50-51
    • Keith, C.T.1    Schreiber, S.L.2
  • 17
    • 0029968296 scopus 로고    scopus 로고
    • Phosphoinositides as regulators in membrane traffic
    • DeCamilli, P., Emr, S. D., McPherson, P. S., Novick, P. (1996) Phosphoinositides as regulators in membrane traffic. Science. 271, 1533-1538.
    • (1996) Science , vol.271 , pp. 1533-1538
    • DeCamilli, P.1    Emr, S.D.2    McPherson, P.S.3    Novick, P.4
  • 19
    • 0023185824 scopus 로고
    • Calcium- and phospholipid-dependent protein kinase C and phosphatidylinositol kinase: Two major phosphorylation systems in the cornea
    • Bazan, H. E. P., Dobard, P., Reddy, S. T. K. (1987) Calcium- and phospholipid-dependent protein kinase C and phosphatidylinositol kinase: two major phosphorylation systems in the cornea. Curr. Eye Res. 6, 667-673.
    • (1987) Curr. Eye Res. , vol.6 , pp. 667-673
    • Bazan, H.E.P.1    Dobard, P.2    Reddy, S.T.K.3
  • 20
    • 0030249058 scopus 로고    scopus 로고
    • Effect of epidermal growth factor on phosphatidylinositol 3-kinase activity in rabbit corneal epithelial cells
    • Zhang, Y., Akhtar, R. A. (1996) Effect of epidermal growth factor on phosphatidylinositol 3-kinase activity in rabbit corneal epithelial cells. Exp. Eye Res. 63, 265-275.
    • (1996) Exp. Eye Res. , vol.63 , pp. 265-275
    • Zhang, Y.1    Akhtar, R.A.2
  • 21
    • 0015334640 scopus 로고
    • Modification of the Lowry procedure for the analysis of proteolipid protein
    • Lees, M. B., Paxman, S. (1972) Modification of the Lowry procedure for the analysis of proteolipid protein. Anal. Biochem. 47, 184-192.
    • (1972) Anal. Biochem. , vol.47 , pp. 184-192
    • Lees, M.B.1    Paxman, S.2
  • 22
    • 0019554465 scopus 로고
    • Alkaline-O-→N-transacylation
    • Clarke, N. G., Dawson, R. M. C. (1981) Alkaline-O-→N-transacylation. Biochem. J. 195, 301-306.
    • (1981) Biochem. J. , vol.195 , pp. 301-306
    • Clarke, N.G.1    Dawson, R.M.C.2
  • 23
    • 0024601010 scopus 로고
    • PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
    • Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P. and Cantley, L. C. (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 57, 167-175.
    • (1989) Cell , vol.57 , pp. 167-175
    • Auger, K.R.1    Serunian, L.A.2    Soltoff, S.P.3    Libby, P.4    Cantley, L.C.5
  • 24
    • 0029849774 scopus 로고    scopus 로고
    • Association between phosphatidyl- inositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1 stimulated macrophages
    • Kanagasundaram, V., Jaworowski, A., Hamilton, J. A. (1996) Association between phosphatidyl- inositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1 stimulated macrophages. Biochem. J. 320, 69-77.
    • (1996) Biochem. J. , vol.320 , pp. 69-77
    • Kanagasundaram, V.1    Jaworowski, A.2    Hamilton, J.A.3
  • 25
    • 0026563978 scopus 로고
    • Insulin treatment stimulates the tyrosine phosphorylation of the α-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo
    • Hayashi, H., Kamohara, S., Nishioka, Y., Kanai, F., Miyake, N., Fukui, Y., Shibasaki, F., Takenawa, T., Ebina, Y, (1992) Insulin treatment stimulates the tyrosine phosphorylation of the α-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo. J. Biol. Chem. 267, 22575-22580.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22575-22580
    • Hayashi, H.1    Kamohara, S.2    Nishioka, Y.3    Kanai, F.4    Miyake, N.5    Fukui, Y.6    Shibasaki, F.7    Takenawa, T.8    Ebina, Y.9
  • 27
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3- Kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C. J., Matter, W. F., Hui, K. Y., Brown, R. F. (1994) A specific inhibitor of phosphatidylinositol 3- kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 28
    • 0022639405 scopus 로고
    • Protein synthesis during corneal epithelial wound healing
    • Zieske, J. D., Gipson, I. K. (1986) Protein synthesis during corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci. 27, 1-7.
    • (1986) Invest. Ophthalmol. Vis. Sci. , vol.27 , pp. 1-7
    • Zieske, J.D.1    Gipson, I.K.2
  • 29
    • 0016775113 scopus 로고
    • The healing of corneal epithelial abrasions in the rabbit: A scanning electron microscope study
    • Pfister, R. R. (1975) The healing of corneal epithelial abrasions in the rabbit: a scanning electron microscope study. Invest Ophthal. Vis. Sci. 14, 648-661.
    • (1975) Invest Ophthal. Vis. Sci. , vol.14 , pp. 648-661
    • Pfister, R.R.1
  • 32
    • 0030926967 scopus 로고    scopus 로고
    • Epidermal growth factor stimulation of phosphatidylinositol 3-kinase during wound closure in rabbit corneal epithelial cells
    • Zhang, Y., Akhtar, R. A. (1997) Epidermal growth factor stimulation of phosphatidylinositol 3-kinase during wound closure in rabbit corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 38, 1139-1148.
    • (1997) Invest. Ophthalmol. Vis. Sci. , vol.38 , pp. 1139-1148
    • Zhang, Y.1    Akhtar, R.A.2
  • 33
    • 0028567793 scopus 로고
    • Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells
    • Wilson, S. E., He, Y., Weng, J., Zieske, J. D., Jester, J. V., Schultz, G. S. (1994) Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Exp. Eye Res. 59, 665-678.
    • (1994) Exp. Eye Res. , vol.59 , pp. 665-678
    • Wilson, S.E.1    He, Y.2    Weng, J.3    Zieske, J.D.4    Jester, J.V.5    Schultz, G.S.6
  • 35
    • 0027450410 scopus 로고
    • A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity
    • Carpenter, C. L., Auger, K. R., Duckworth, B. C., Hou, W., Schaffhausen, B., Cantley, L. C. (1993) A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol. Cell. Biol. 13, 1657-1665.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1657-1665
    • Carpenter, C.L.1    Auger, K.R.2    Duckworth, B.C.3    Hou, W.4    Schaffhausen, B.5    Cantley, L.C.6
  • 36
    • 0030614873 scopus 로고    scopus 로고
    • Specific increase in p85α expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol 3-kinase activity in cultured muscle cells
    • Giorgino, F., Pedrini, M. T., Matera, L., Smith, R. J. (1997) Specific increase in p85α expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol 3-kinase activity in cultured muscle cells. J. Biol. Chem. 272, 7455-7463.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7455-7463
    • Giorgino, F.1    Pedrini, M.T.2    Matera, L.3    Smith, R.J.4
  • 37
    • 0027214407 scopus 로고
    • Growth factors and wound healing. II. Role in normal and chronic wound healing
    • Bennett, N. T., Schultz, G. S. (1993) Growth factors and wound healing. II. Role in normal and chronic wound healing. Am. J. Surg. 166, 74-81.
    • (1993) Am. J. Surg. , vol.166 , pp. 74-81
    • Bennett, N.T.1    Schultz, G.S.2
  • 41
    • 0028815491 scopus 로고
    • Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts
    • Borner, C., Ueffing, M., Jaken, S., Parker, P. J., Weinstein, I. B. (1995) Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. J. Biol. Chem. 270, 78-86.
    • (1995) J. Biol. Chem. , vol.270 , pp. 78-86
    • Borner, C.1    Ueffing, M.2    Jaken, S.3    Parker, P.J.4    Weinstein, I.B.5
  • 42
    • 0029068521 scopus 로고
    • Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation
    • Seedford, K., Shearaman, M., Ulbrich, A. (1995) Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation. J. Biol. Chem. 32, 18953- 18960.
    • (1995) J. Biol. Chem. , vol.32 , pp. 18953-18960
    • Seedford, K.1    Shearaman, M.2    Ulbrich, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.