Effect of SMP-500, a novel ACAT inhibitor, on hepatic cholesterol disposition in rats

Lipids

Volumn 37, Issue 4, 2002, Pages 395-400

  Ioriya, Katsuhisa ^a   Nishimura, Takeshi ^a   Ohashi, Naohito ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ESTERIFICATION;

DISPOSITION;

LIPIDS;

ANTILIPEMIC AGENT; BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; MESSENGER RNA; N [2,6 BIS(1 METHYLETHYL)PHENYL] N' [1 BUTYL 1,2 DIHYDRO 2 OXO 4 [3 (3 PYRIDYLMETHOXY)PHENYL] 1,8 NAPHTHYRIDIN 3 YL] UREA NITRATE; SMP 500; SUCROSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; LIVER METABOLISM; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BASE SEQUENCE; CHOLESTEROL; DNA PRIMERS; ENZYME INHIBITORS; LIVER; NAPHTHYRIDINES; RATS; STEROL O-ACYLTRANSFERASE; UREA;

ANIMALIA;

EID: 0036235975     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s1145-002-0907-1     Document Type: Article

References (41)

1. Role of Acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism
2. Effect of dietary fat saturation cholesterol and cholestyramine on Acyl-CoA cholesterol acyltransferase activity in rabbit intestinal microsomes
3. Role of Acyl-CoA: Cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit
4. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification
5. Cholesterol is required for secretion of very low density lipoprotein by rat liver
6. Regulation of ApoB secretion from HepG2 cells: Evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge
7. Cholesterol ester synthesis in normal and atherosclerotic aortas of rabbit and rhesus monkeys
8. Changes in aortic cholesterol-esterifying activity in rabbits fed cholesterol for three days
9. Studies of the mechanism of augmented synthesis of cholesteryl ester in atherosclerotic rabbit aortic microsomes
10. ACAT inhibitors: Potential antiatherosclerotic agents
11. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
12. The ACAT inhibitor CI-1011 is effective in the prevention and regression of aortic fatty streak area in Hamsters
13. Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs
14. Post-prandial hyperlipidemia in streptozotocin-induced diabetic rats is due to abnormal increase in intestinal Acyl coenzyme A: Cholesterol acyltransferase activity
15. Pharmacological profile of F 12511, (S)-2′,3′,5′- trimethyl-4′-hydroxy-α-dodecylthioacetanilide a powerful and systemic acylcoenzyme A: Cholesterol acyltransferase inhibitor
16. F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet
17. ACAT inhibitor avasimibe lowers VLDL-C and triglycerides in patients with hypertriglyceridemia
18. Effect of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans
19. Effect of the ACAT inhibitor Dup128 on cholesterol absorption and serum cholesterol in humans
20. Effect of SMP-500, a novel Acyl-CoA: Cholesterol acyltransferase inhibitor, on the cholesterol esterification and its hypocholesterolemic properties
21. Sterol metabolism studies in the rat. Effect of primary bile acids (sodium taurochenodeoxycholate and sodium taurocholate) on sterol metabolism
22. Hydroxylations in biosynthesis of bile acids: Isolation of subfractions with different substrate specificity from cytochrome P-450LM4
23. A form of rabbit liver cytochrome P-450 that catalyzes the 7α-hydroxylation of cholesterol
24. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster
25. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT
26. A simple method for the isolation and purification of total lipids from animal tissues
27. Microanalysis of tissue cholesterol using a fluorometric enzymatic method
28. The physicochemical basis of cholesterol gallstone formation in man
29. TMP-153, a novel ACAT inhibitor lowers serum cholesterol through its hepatic action in golden Hamsters
30. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
31. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
32. Acyl-coenzyme A: Cholesterol acyltransferase inhibitor avasimibe, stimulates bile acid synthesis and cholesterol 7α-hydroxylase in cultured rat hepatocytes and in vivo in the rat
33. ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): Stimulation of bile acid production by HL-004
34. Regulation of cholesterol 7 α-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat
35. Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 α-hydroxylase activities and mRNA levels in the rat
36. Differential feedback regulation of cholesterol 7 α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes
37. Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 α-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme a reductase or low density lipoprotein receptor
38. Parameters of cholesterol metabolism in human hepatoma cell line, HepG2
39. Divergent pharmacologic activities of PD-132301-2 and CL-277082, urea inhibitors of Acyl-CoA: Cholesterol acyltransferase
40. Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol
41. Inhibitors of Acyl-CoA: Cholesterol O-Acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: An Acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets