Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C

Cancer Chemotherapy and Pharmacology

Volumn 49, Issue 5, 2002, Pages 412-418

  Kelner, Michael J ^a   McMorris, Trevor C ^b   Rojas, Rafael J ^a   Trani, Nicole A ^a   Estes, Leita ^a  

^a UCSD MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Illudin; Irofulven; Mitomycin C; TEPA; Thiotepa

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; DIAZIQUONE; MITOMYCIN C; NSC 524926; NSC 54054; PORFIROMYCIN; TEPA; THIOTEPA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CONVALESCENCE; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SCREENING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; MONOTHERAPY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; AZIRIDINES; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MITOMYCIN; NEOPLASM TRANSPLANTATION; SESQUITERPENES; THIOTEPA; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0036235404     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-001-0410-6     Document Type: Article

References (42)

1. Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model
2. The median-effect principle and the combination index for quantification of synergism and antagonism
3. Applications of median-effects principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents
4. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
5. Interaction of N,N′,N″-triethylenethiophosphoramide and N,N′,N″-triethylenephosphoramide with cellular DNA
6. Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats
7. Phase I and pharmacokinetic study of irofulven, a novel mushroom-derived cytotoxin, administered for five consecutive days every four weeks in patients with advanced solid malignancies
8. 14C] thiotepa: Labeling of phosphatidylethanolamine
9. Plasma pharmacokinetics and tissue distribution of thiotepa in mice
10. Cellular activation of diaziquone [2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone] to its free radical species
11. Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with topotecan or paclitaxel in the MV522 lung carcinoma xenograft model
12. Drug uptake and cellular targets of hydroxymethylacylfulvene (HMAF)
13. Preclinical evaluations of illudins as anticancer agents
14. Preclinical evaluation of illudins as anticancer agents: Basis for selective cytotoxicity
15. Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells
16. Efficacy of acylfulvene illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: Retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells
17. Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
18. Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells
19. Efficacy of MGI 114 against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft
20. Characterization of acylfulvene histiospecific toxicity in human tumor cells
21. Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines
22. Efficacy of MGI 114 against the MRP-positive metastatic MV522 lung carcinoma xenograft
23. Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan
24. Classification of human colorectal adenocarcinoma cell lines
25. Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S
26. The structures of the basidiomycete metabolites illudin S and illudin M
27. Fungal metabolites. The structures of the novel sesquiterpenoids illudin-S and -M
28. Acylfulvenes, a new class of potent antitumor agents
29. Experimental correlations of in vitro drug sensitivity with in vivo responses to thiotepa in a panel of murine colon tumors
30. The murine disposition and pharmacokinetics of the antineoplastic agent, diaziquone (NSC 182986)
31. Mechanism of DNA strand breakage and interstrand cross-linking by diaziridinylbenzoquinone (diaziquone) in human cells and relation to cell killing
32. Use of nude mouse xenografts as preclinical drug screen: In vivo activity of established chemotherapeutic agents against melanomas and ovarian carcinoma xenografts
33. Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N′, N″-triethylene-thiophosphoramide
34. A screening method for isolating DNA repair-deficient mutants of CHO cells
35. The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
36. Microscopic metastasis of a human lung carcinoma cell line in athymic nude mice: Isolation of a metastatic variant
37. Phase II trial of irofulven (MGI 114) in patients with advanced pancreatic cancer who have progressed on gemcitabine
38. MGI 114: Augmentation of antitumor activity when combined with topotecan
39. Targeting apoptosis by hydroxymethylacylfulvene in combination with gamma radiation in prostate tumor cells
40. Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF)
41. Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)