메뉴 건너뛰기




Volumn 14, Issue 1, 2000, Pages 136-141

Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan

Author keywords

HMAF; MGI 114; Synergy; Topotecan; Xenograft

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ANTILEUKEMIC AGENT; TOPOTECAN;

EID: 0033959278     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401611     Document Type: Article
Times cited : (26)

References (35)
  • 1
    • 76549234433 scopus 로고
    • Antibiotic substances from Basidiomycetes. VII. Clitocybe illudens
    • Anchel M, Hervey A, Robbins WJ. Antibiotic substances from Basidiomycetes. VII. Clitocybe illudens. Proc Natl Acad Sci USA 1950; 36: 30-36.
    • (1950) Proc Natl Acad Sci USA , vol.36 , pp. 30-36
    • Anchel, M.1    Hervey, A.2    Robbins, W.J.3
  • 2
    • 33947481529 scopus 로고
    • The structures of the Basidiomycete metabolites Illudin S and Illudin M
    • McMorris TC, Anchel M. The structures of the Basidiomycete metabolites Illudin S and Illudin M. J Amer Chem Soc 1963; 85: 831-832.
    • (1963) J Amer Chem Soc , vol.85 , pp. 831-832
    • McMorris, T.C.1    Anchel, M.2
  • 3
    • 8244228308 scopus 로고
    • Fungal metabolites. The structure of the novel sesquiterpenoids Illudin-S and -M
    • McMorris TC, Anchel M. Fungal metabolites. The structure of the novel sesquiterpenoids Illudin-S and -M. J Amer Chem Soc 1965; 87: 1594-1600.
    • (1965) J Amer Chem Soc , vol.87 , pp. 1594-1600
    • McMorris, T.C.1    Anchel, M.2
  • 5
    • 0025168447 scopus 로고
    • Preclinical evaluation of illudins as anticancer agents: Basis for selective cytotoxicity
    • Kelner MJ, McMorris TC, Taetle R. Preclinical evaluation of illudins as anticancer agents: basis for selective cytotoxicity. J Natl Cancer Inst 1990; 82: 1562-1565.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1562-1565
    • Kelner, M.J.1    McMorris, T.C.2    Taetle, R.3
  • 6
    • 0028168639 scopus 로고
    • Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents
    • Kelner MJ, McMorris TC, Estes L, Rutherford M, Montoya M, Goldstein J, Samson K, Starr R, Taetle R. Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. Biochem Pharmacol 1994; 48: 403-409.
    • (1994) Biochem Pharmacol , vol.48 , pp. 403-409
    • Kelner, M.J.1    McMorris, T.C.2    Estes, L.3    Rutherford, M.4    Montoya, M.5    Goldstein, J.6    Samson, K.7    Starr, R.8    Taetle, R.9
  • 7
    • 0029142483 scopus 로고
    • In vitro and in vivo studies on the anticancer activity of dehydroilludin M
    • Kelner MJ, McMorris TC, Taetle R. In vitro and in vivo studies on the anticancer activity of dehydroilludin M. Anticancer Res 1995; 15: 873-878.
    • (1995) Anticancer Res , vol.15 , pp. 873-878
    • Kelner, M.J.1    McMorris, T.C.2    Taetle, R.3
  • 8
    • 0028883899 scopus 로고
    • Efficacy of Acyltulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: Retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells
    • Kelner MJ, McMorris TC, Estes L, Starr RJ, Rutherford M, Montoya M, Samson KM, Taetle R. Efficacy of Acyltulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells. Cancer Res 1995; 55: 4936-4940.
    • (1995) Cancer Res , vol.55 , pp. 4936-4940
    • Kelner, M.J.1    McMorris, T.C.2    Estes, L.3    Starr, R.J.4    Rutherford, M.5    Montoya, M.6    Samson, K.M.7    Taetle, R.8
  • 9
    • 0029800935 scopus 로고    scopus 로고
    • Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
    • Kelner MJ, McMorris TC, Estes L, Wang W, Samson KM, Taetle R. Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents. Invest New Drugs 1996; 14: 161-167.
    • (1996) Invest New Drugs , vol.14 , pp. 161-167
    • Kelner, M.J.1    McMorris, T.C.2    Estes, L.3    Wang, W.4    Samson, K.M.5    Taetle, R.6
  • 12
    • 0000763311 scopus 로고    scopus 로고
    • In vitro antitumor activity of MGI 114 in combination with topotecan, cisplatin, etoposide, or gemcitabine
    • Barrera H, MacDonald JR, Hilsenbeck S, Weitman S. In vitro antitumor activity of MGI 114 in combination with topotecan, cisplatin, etoposide, or gemcitabine. Proc Amer Assoc Cancer Res 1998; 39: 527.
    • (1998) Proc Amer Assoc Cancer Res , vol.39 , pp. 527
    • Barrera, H.1    MacDonald, J.R.2    Hilsenbeck, S.3    Weitman, S.4
  • 14
    • 0001103571 scopus 로고    scopus 로고
    • Evidence of synergistic antitumor activity with MGI 114 in combination with Irinotecan or 5-fluorouracil against a human colon tumor xenograft model
    • Marty J, MacDonald J, Mangold G, Weitman S, Von Hoff D. Evidence of synergistic antitumor activity with MGI 114 in combination with Irinotecan or 5-fluorouracil against a human colon tumor xenograft model. Proc Amer Assoc Cancer Res 1998; 39: 527.
    • (1998) Proc Amer Assoc Cancer Res , vol.39 , pp. 527
    • Marty, J.1    MacDonald, J.2    Mangold, G.3    Weitman, S.4    Von Hoff, D.5
  • 16
    • 0023106388 scopus 로고
    • Retinoid acid-induced monocytic differentiation of HL60/MRI, a cell lined derived from a transplantable HL60 tumor
    • Omasum M, Asemia J, Breitman TR. Retinoid acid-induced monocytic differentiation of HL60/MRI, a cell lined derived from a transplantable HL60 tumor. Cancer Res 1987; 47: 1434-1440.
    • (1987) Cancer Res , vol.47 , pp. 1434-1440
    • Omasum, M.1    Asemia, J.2    Breitman, T.R.3
  • 17
    • 0024213553 scopus 로고
    • Changes in c-myc, c-f's, and N-ras proto-oncogene expression associated with retinoid acid-induced monocytic differentiation of human leukemia HL60/MRI cells
    • Omasum M, Breitman TR. Changes in c-myc, c-f's, and N-ras proto-oncogene expression associated with retinoid acid-induced monocytic differentiation of human leukemia HL60/MRI cells. Cancer Res 1988; 48: 6733-6738.
    • (1988) Cancer Res , vol.48 , pp. 6733-6738
    • Omasum, M.1    Breitman, T.R.2
  • 18
    • 0003030325 scopus 로고
    • Applications of median-effects principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents
    • Harrap KR, Connors TA (eds). Academic Press: New York
    • Chou T-C, Talky P. Applications of median-effects principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. In: Harrap KR, Connors TA (eds). New Avenues in Developmental Cancer Chemotherapy. Academic Press: New York, 1987, pp 37-64.
    • (1987) New Avenues in Developmental Cancer Chemotherapy , pp. 37-64
    • Chou, T.-C.1    Talky, P.2
  • 19
    • 0002658306 scopus 로고
    • The median-effect principle and the combination index for quantification of synergism and antagonism
    • Chou T-C, Rideout DE (eds). Academic Press: New York
    • Chou T-C. The median-effect principle and the combination index for quantification of synergism and antagonism. In: Chou T-C, Rideout DE (eds). Synergism and Antagonism in Chemotherapy. Academic Press: New York, 1991, pp 61-102.
    • (1991) Synergism and Antagonism in Chemotherapy , pp. 61-102
    • Chou, T.-C.1
  • 23
    • 0029834306 scopus 로고    scopus 로고
    • (Hydroxymethyl)acylfulvene: An illudin derivative with superior antitumor properties
    • McMorris TC, Kelner MJ, Wang W, Yu J, Estes LA, Taetle R. (Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties. J Nat Prod 1996; 59: 896-899.
    • (1996) J Nat Prod , vol.59 , pp. 896-899
    • McMorris, T.C.1    Kelner, M.J.2    Wang, W.3    Yu, J.4    Estes, L.A.5    Taetle, R.6
  • 24
    • 0023146915 scopus 로고
    • Use of nude mouse xenografts as preclinical drug screen: In vivo activity of established chemotherapeutic agents against melanomas and ovarian carcinoma xenografts
    • Taetle R, Rosen F, Abramson I, Bendetti J, Howell S. Use of nude mouse xenografts as preclinical drug screen: in vivo activity of established chemotherapeutic agents against melanomas and ovarian carcinoma xenografts. Cancer Treat Rep 1987; 71: 297-304.
    • (1987) Cancer Treat Rep , vol.71 , pp. 297-304
    • Taetle, R.1    Rosen, F.2    Abramson, I.3    Bendetti, J.4    Howell, S.5
  • 26
    • 0001458215 scopus 로고
    • Effects of more than one inhibitor
    • Webb JL (ed). Academic Press: New York
    • Webb JL. Effects of more than one inhibitor. In: Webb JL (ed). Enzymes and Metabolic Inhibitors, vol 1. Academic Press: New York, 1963, pp 66-79.
    • (1963) Enzymes and Metabolic Inhibitors , vol.1 , pp. 66-79
    • Webb, J.L.1
  • 27
    • 0029036955 scopus 로고
    • The search for synergy: A critical review from a response surface perspective
    • Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 1995; 47: 331-385.
    • (1995) Pharmacol Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 28
    • 0028153260 scopus 로고
    • Computerized quantitation of synergism and antagonism of Taxol, Topotecan, and Cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
    • Chou T-C, Motzer JR, Tong Y, Bosl GJ. Computerized quantitation of synergism and antagonism of Taxol, Topotecan, and Cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 1994; 86: 1517-1523.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1517-1523
    • Chou, T.-C.1    Motzer, J.R.2    Tong, Y.3    Bosl, G.J.4
  • 30
    • 0030718488 scopus 로고    scopus 로고
    • Effect on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene, 6-hydroxymethylacylfulvene (HMAF, MGI 114)
    • Woynarowski JM, Napier C, Koester SK, Chen S-F, Troyer D, Chapman W, MacDonald JR. Effect on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene, 6-hydroxymethylacylfulvene (HMAF, MGI 114). Biochem Pharmacol 1997; 54: 1181-1193.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1181-1193
    • Woynarowski, J.M.1    Napier, C.2    Koester, S.K.3    Chen, S.-F.4    Troyer, D.5    Chapman, W.6    MacDonald, J.R.7
  • 32
    • 0030805565 scopus 로고    scopus 로고
    • When helicase and topoisomerase meet!
    • Duget M. When helicase and topoisomerase meet! J Cell Sci 1997; 110: 1345-1350.
    • (1997) J Cell Sci , vol.110 , pp. 1345-1350
    • Duget, M.1
  • 33
    • 0342284938 scopus 로고
    • SKF 104864 (Topotecan): Preclinical studies of a new topoisomerase inhibitor
    • Burris H, Kuhn J, Johnson K, Von Hoff D. SKF 104864 (Topotecan): preclinical studies of a new topoisomerase inhibitor. Proc Am Soc Clin Oncol 1990; 11: 216.
    • (1990) Proc Am Soc Clin Oncol , vol.11 , pp. 216
    • Burris, H.1    Kuhn, J.2    Johnson, K.3    Von Hoff, D.4
  • 34
    • 0010263172 scopus 로고
    • Phase I and pharmacologic study of topotecan (SKF 104864): A novel topoisomerase I inhibitor
    • Rowinsky E, Grochow L, Hendritks C. Phase I and pharmacologic study of topotecan (SKF 104864): a novel topoisomerase I inhibitor. Proc Am Soc Clin Oncol 1991; 10: 93.
    • (1991) Proc Am Soc Clin Oncol , vol.10 , pp. 93
    • Rowinsky, E.1    Grochow, L.2    Hendritks, C.3
  • 35
    • 0343590059 scopus 로고    scopus 로고
    • A phase II trial of MGI 114 in patients with hormone-refractory prostate cancer
    • Senser NN, Rakvica R, Chao H, Smith S. A phase II trial of MGI 114 in patients with hormone-refractory prostate cancer. Proc Am Soc Clin Oncol 1999; 18: 321A.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Senser, N.N.1    Rakvica, R.2    Chao, H.3    Smith, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.