Pulsatile insulin release from mouse islets occurs in the absence of stimulated entry of Ca2+

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1860-1863

  Westerlund, Johanna ^a   Hellman, Bo ^a   Bergsten, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

ATP; Clonidine; Cytoplasmic Ca2+; Diazoxide; Glucose

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CLONIDINE; DIAZOXIDE; GLUCOSE; INSULIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; ENZYME LINKED IMMUNOSORBENT ASSAY; FOURIER TRANSFORMATION; HORMONAL REGULATION; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

ANIMALS; CALCIUM; CELLS, CULTURED; CLONIDINE; DIAZOXIDE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOURIER ANALYSIS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; KINETICS; MICE; MICE, OBESE; TIME FACTORS;

EID: 0029872719     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118616     Document Type: Article

References (25)

1. Jaspan, P.J., E. Lever, K S Polonsky, and E. Van Cautcr. 1986. In vivo pulsatility of pancreatic islet peptides. Am J. Physiol. 251:E215-E226.
2. Lefebvie, P.J., G. Paolisso, A J. Scheen, and J.C. Henquin. 1987. Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications. Diabetologia. 30.433-452
3. 2+ in the pancreatic β-cell. Biochem. Biophys Res. Commun 151:1299-1304.
4. 2+ oscillations in pancreatic β-cells Biochim. Biophys. Acta. 1113:295-305.
5. 2+ oscillations in clusters of pancreatic β-cells exposed to glucose. Cell Calcium 12:229-240.
6. 2+ and insulin release in glucose-stimulated pancreatic islets. J Biol. Chem. 269:8749-8753
7. Porksen, N., S. Munn, J. Steers, S Vore, J. Veldhuis, and P. Butler. 1995. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am. J Physiol 269:E478-E488.
8. Hellman, B. 1965 Studies in obese-hyperglycemic mice Ann. NY Acad. Sci. 131:541-558
9. 2+ in pancreatic islets correspond to pulsatile insulin release Am J. Physiol. 268:E282-E287
10. 2+ indicators with greatly improved fluorescence properties. J Biol. Chem. 260:3440-3450.
11. Bergsten, P., and B. Hellman 1993. Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes. 42: 670-674.
12. Bergsten, P., and B. Hellman. 1993. Glucose-induced cycles of insulin release can be resolved into distinct periods of secretory activity. Biochem. Biophys. Res. Commun. 192:1182-1188.
13. Berridge, M.J., and G. Dupont. 1994. Spatial and temporal signalling by calcium. Curr. Biol. 6:267-274.
14. Clapham, D.E. 1995. Calcium signalling. Cell 80:259-268.
15. Corkey, B E , K. Tornheim, J.T. Deeney, M.C. Glennon, J.C. Parker, P.M. Matchinsky, N.B. Ruderman, and M. Prentki. 1988. Linked oscillations of free calcium and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J. Biol. Chem 263:4254-4258.
16. 2+, oxygen consumption and insulin release in glucose-stimulated rat pancreatic islets. J. Biol Chem. 266:9314-9319.
17. + channel activity provide evidence for inherent metabolic oscillations in pancreatic β-cells. Biochem. Biophys. Res. Commun. 205:880-885.
18. 2+ oscillations in pancreatic islet cells secreting glucagon and somatostatin. Biochem Biophys. Res Commun. 208:644-649.
19. Marchetti, P , D.W. Sharp, M. Mclear, R. Gingerich, E. Finke, B. Olack, C. Swanson, R Giannarelli, R. Navalesi, and P.E. Lacy. 1994. Pulsatile insulin secretion from isolated human pancreatic islets. Diabetes. 43:827-830.
20. 2+ signalling and insulin release in human pancreatic β-cells. Diabetologia. 37(Suppl. 2):S11-S20.
21. Hellman, B., E. Gylfe, E Grapengiesser, P E Lund, and A. Marcström. 1992. Cytoplasmic calcium and insulin secretion. In Nutrient Regulation of Insulin Secretion. P.R. Flatt, editor. Portland Press Ltd., London, UK. 213-246.
22. Hellman, B., E. Gylfe, P. Bergsten, E. Grapengiesser, P.E. Lund, A. Berts, S. Dryselius, A. Tengholm, Y.J. Liu, M. Eberhardsson, and R.H Chow. 1994. The role of Ca2+ in the release of pancreatic islet hormones. Diabete & Metab. 20.123-131.
23. Garcia-Morales, P., S P Dufrane, A. Sener, I. Valverde, and W.J. Malaisse. 1984 Inhibitory effect of clonidine upon adenylate cyclase activity, cyclic AMP production and insulin release in rat pancreatic islets. Biosci. Rep 4:511-521
24. Panten, U., J. Burgfeld, F. Goerke, M. Rennicke, M. Schwanstecher, A. Wallasch, B.J. Zunkler, and S Lenzen. 1989. Control of insulin secretion of sulphonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets. Biochem. Pharmacol. 38:1217-1229.
25. O'Rahilly, S., R.C. Turner, and D.R. Matthews. 1988 Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med. 318.1225-1230.