Pulsatile insulin release from pancreatic islets with nonoscillatory elevation of cytoplasmic Ca2+

Journal of Clinical Investigation

Volumn 100, Issue 10, 1997, Pages 2547-2551

  Westerlund, Johanna ^a   Gylfe, Erik ^a   Bergsten, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Adenosine triphosphate; Depolarization; Insulin secretion; Islets of Langerhaps; Tolbutamide

Indexed keywords

CALCIUM ION; HORMONE RECEPTOR; INSULIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; RECEPTOR UPREGULATION;

EID: 0030734035     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119797     Document Type: Article

References (35)

1. Bergsten, P., and B. Hellman. 1993. Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes. 42:670-674.
2. Stagner, J.I., E. Samols, and G.C. Weir. 1980. Sustained oscillations of insulin glucagon and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration. J. Clin. Invest. 65:939-942.
3. Jaspan, J.B., E. Lever, K.S. Polonsky, and E. Van Cauter. 1986. In vivo pulsatility of pancreatic islet peptides. Am. J. Physiol. 251:E215-E226.
4. Pørksen, N., S. Munn, J. Steers, S. Vore, J. Veldhuis, and P. Butler. 1995. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am. J. Physiol. 269:E478-E488.
5. Lang, D.A., D.R. Matthews, J. Peto, and R.C. Turner. 1979. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N. Engl. J. Med. 301:1023-1027.
6. Goodner, C.J., B.C. Walike, D.J. Koerker, J.W. Ensinck, A.C. Brown, E.W. Chideckel, J. Palmer, and L. Kalnasy. 1977. Insulin, glucagon and glucose exhibits synchronous sustained oscillations in fasting monkeys. Science. 195:177-179.
7. Lefèbvre, P.J., G. Paolisso, A.J. Scheen, and J.C. Henquin. 1987. Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications. Diabetologia. 30:443-452.
8. Matthews, D.R., B.A. Naylor, R.G. Jones, G.M. Ward, and R.C. Turner. 1983. Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes. 32:617-621.
9. Paolisso, G., S. Sgambato, R. Torella, M. Varricchio, A.J. Scheen, F. D'Onofrio, and PJ. Lefèbvre. 1988. Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes. J. Clin. Endocrinol. Metab. 66:1220-1226.
10. Lang, D.A., D.R. Matthews, M. Burnett, and R.C. Turner. 1981. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes. 30:435-439.
11. O'Rahilly, S., R.C. Turner, and D.R. Matthews. 1988. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N. Engl. J. Med. 318:1225-1230.
12. Grodsky, G.M., and L.L. Bennett. 1966. Cation requirements for insulin secretion in the isolated perfused pancreas. Diabetes. 15:910-912.
13. Milner, R.D.G., and C.N. Hales. 1967. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia. 3:47-49.
14. Devis, G., G. Somers, E. Van Obberghen, and W.J. Malaisse. 1975. Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil. Diabetes. 24:247-251.
15. Gylfe, H. 1988. Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse β-cells. J. Biol. Chem. 263:13750-13754.
16. Yaseen, M.A., K.C. Pedley, and S.L. Howell. 1982. Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge. Biochem. J. 206:81-87.
17. 2+ in the pancreatic β-cell. Biochem. Biophys. Res. Commun. 151:1299-1304.
18. 2+ oscillations in clusters of pancreatic β-cells exposed to glucose. Cell Calcium. 12:229-240.
19. 2+ and insulin release in glucose-stimulated pancreatic islets. J. Biol. Chem. 269:8749-8753.
20. Lang, D.A., D.R. Matthews, M. Burnett, G.M. Ward, and R.C. Turner. 1982. Pulsatile, synchronous basal insulin and glucagon secretion in man. Diabetes. 31:22-26.
21. 2+. J. Clin. Invest. 97:1860-1863.
22. Goodner, C.J., I.R. Sweet, and H.C. Harrison. 1988. Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes. Diabetes. 37:1316-1323.
23. Hellman, B. 1965. Studies in obese-hyperglycemic mice. Ann. NY Acad. Sci. 131:541-558.
24. 2+ in pancreatic islets correspond to pulsatile insulin release. Am. J. Physiol. 268:E282-E287.
25. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
26. Ashcroft, F.M., and P. Rorsman. 1989. Electrophysiology of the pancreatic β-cell. Prog. Biophys. Mol. Biol. 54:87-143.
27. 2+ in mouse pancreatic β-cells. J. Physiol. (Lond). 485:607-617.
28. 2+ transients. J. Biol. Chem. 269:27310-27314.
29. + channel activity provide evidence for inherent metabolic oscillations in pancreatic β-cells. Biochem. Biophys. Res. Commun. 205:880-885.
30. + channel in mouse pancreatic β-cells. Pflügers Arch. 407:493-499.
31. Renström, E., L. Eliasson, K. Bokvist, and P. Rorsman. 1996. Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J. Physiol. (Lond) 494:41-52.
32. Grill, V., and E. Cerasi. 1973. Activation by glucose of adenyl cyclase in pancreatic islets of the rat. FEBS (Fed. Enr. Biochem. Soc.) Lett. 33:311-314.
33. Hellman, B., L.Å. Idahl, Å. Lernmark, and I.B. Täljedal. 1974. The pancreatic β-cell recognition of insulin secretagogues: does cyclic AMP mediate the effect of glucose? Proc. Natl. Acad. Sci. (USA). 71:3405-3409.
34. + channels in mouse B cells. J. Clin. Invest. 91:871-880.
35. Peiris, A.N., J.I. Stagner, R.L. Vogel, A. Nakagawa, and E. Samols. 1992. Body fat distribution and peripheral insulin sensitivity in healthy men: role of insulin pulsatility. J. Clin. Endocrinol. Metab. 75:290-294.